The role of herpesvirus entry mediator as a negative regulator of T cell–mediated responses

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity

2004 • 1,213 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

2001 • 916 citations

Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis

1998 • 904 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator

1998 • 760 citations

B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

2004 • 595 citations

The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

2003 • 516 citations

LIGHT, a TNF-Like Molecule, Costimulates T Cell Proliferation and Is Required for Dendritic Cell-Mediated Allogeneic T Cell Response

2000 • 394 citations

Priming of naive T cells inside tumors leads to eradication of established tumors

2004 • 344 citations

Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

2000 • 309 citations

Herpesvirus Entry Mediator, a Member of the Tumor Necrosis Factor Receptor (TNFR) Family, Interacts with Members of the TNFR-associated Factor Family and Activates the Transcription Factors NF-κB and AP-1

1997 • 294 citations

LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer.

1998 • 277 citations

Targeted Disruption of LIGHT Causes Defects in Costimulatory T Cell Activation and Reveals Cooperation with Lymphotoxin β in Mesenteric Lymph Node Genesis

2002 • 255 citations

Constitutive Expression of LIGHT on T Cells Leads to Lymphocyte Activation, Inflammation, and Tissue Destruction

2001 • 240 citations

The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT

2001 • 225 citations

The Lymphotoxin-β Receptor Is Necessary and Sufficient for LIGHT-mediated Apoptosis of Tumor Cells

2000 • 223 citations

B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function

2001 • 220 citations

The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT

2001 • 213 citations

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

2002 • 178 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 174 citations

Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection

2004 • 160 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 152 citations

LIGHT–HVEM signaling and the regulation of T cell-mediated immunity

2003 • 125 citations

Modulation of LIGHT-HVEM Costimulation Prolongs Cardiac Allograft Survival

2002 • 118 citations

Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy

2004 • 118 citations

Cutting Edge: Selective Impairment of CD8+ T Cell Function in Mice Lacking the TNF Superfamily Member LIGHT

2002 • 94 citations

IL-6 Prevents T Cell-Mediated Hepatitis via Inhibition of NKT Cells in CD4+ T Cell- and STAT3-Dependent Manners

2004 • 90 citations

Protection against TNF-Induced Lethal Shock by Soluble Guanylate Cyclase Inhibition Requires Functional Inducible Nitric Oxide Synthase

2000 • 59 citations

Cytokine Inhibitors and Graft‐versus‐Host Disease

1995 • 37 citations

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

2002 • 35 citations