Cytokine Inhibitors and Graft‐versus‐Host Disease

Cytokine dysregulation and acute graft-versus-host disease

1992 • 617 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 565 citations

Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide.

1991 • 448 citations

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin.

1992 • 428 citations

Immunomodulatory and Antimicrobial Efficacy of Intravenous Immunoglobulin in Bone Marrow Transplantation

1990 • 398 citations

Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host disease.

1992 • 385 citations

Risk factors for acute graft‐versus‐host disease

1987 • 360 citations

Cytokine storm of graft-versus-host disease: a critical effector role for interleukin-1.

1993 • 233 citations

IL-1 receptor antagonist and IL-1 beta production in human monocytes are regulated differently.

1991 • 219 citations

Differential cytokine expression in acute and chronic murine graft‐versus‐host‐disease

1993 • 194 citations

Preferential activation of Th2 cells in chronic graft-versus-host reaction.

1993 • 187 citations

Enhancement of Growth of Virulent Strains of Escherichia coli by Interleukin-1

1991 • 185 citations

Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease

1991 • 180 citations

Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat.

1992 • 179 citations

Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction.

1989 • 178 citations

Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease

1992 • 176 citations

Host-Specific Interleukin-2–Secreting Donor T-Cell Precursors as Predictors of Acute Graft-versus-Host Disease in Bone Marrow Transplantation between HLA-Identical Siblings

1992 • 167 citations

Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease

1994 • 141 citations

Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease

1992 • 139 citations

Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versus-host disease after HLA-identical sibling bone-marrow transplantation

1993 • 134 citations

Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice.

1993 • 129 citations

Dissociating graft-vs-host disease from the graft-vs-leukemia effect of allogeneic T cells: the potential role of IL-2.

1992 • 118 citations

ENDOGENOUS IFN-GAMMA DURING HUMAN BONE MARROW TRANSPLANTATION

1990 • 110 citations

Role of tumor necrosis factor alpha in acute graft-versus-host disease and complications following allogeneic bone marrow transplantation.

1993 • 106 citations

Nitric oxide mediates intestinal pathology in graft-vs.-host disease

1992 • 103 citations

In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment.

1990 • 98 citations

THE RELATIONSHIP OF SERUM IL-6 LEVELS TO ACUTE GRAFT-VERSUS-HOST DISEASE AND HEPATORENAL DISEASE AFTER HUMAN BONE MARROW TRANSPLANTATION

1992 • 92 citations

Demonstration of direct involvement of cytokines in graft-versus-host reactions using an in vitro human skin explant model.

1991 • 82 citations

Immunodeficiency in graft-versus-host disease. I. Mechanism of immune suppression.

1988 • 80 citations

Enumeration of lymphokine mRNA-containing cells in vivo in a murine graft-versus-host reaction using the PCR.

1992 • 59 citations

Cytokine gene expression in mice undergoing chronic graft-versus-host disease

1993 • 56 citations

Kinetics of T cell activation in acute and chronic forms of murine graft-versus-host disease.

1991 • 51 citations

Effects of in vivo administration of interferon (IFN)-γ, anti-IFN-γ, or anti-interleukin-4 monoclonal antibodies in chronic autoimmune graft-versus-host disease

1992 • 42 citations

Use of an anti-interleukin-2 receptor monoclonal antibody for GVHD prophylaxis in unrelated donor BMT.

1993 • 40 citations

Quantitative assessment of posttransplant host-specific interleukin-2- secreting T-helper cell precursors in patients with and without acute graft-versus-host disease after allogeneic HLA-identical sibling bone marrow transplantation

1993 • 32 citations

Cytokines in Hemopoiesis, Oncology, and AIDS II

1992 • 30 citations

SERUM LEVELS AND RECEPTOR EXPRESSION OF TUMOR NECROSIS FACTOR-α FOLLOWING HUMAN ALLOGENEIC AND AUTOLOGOUS BONE MARROW TRANSPLANTATION

1992 • 16 citations