Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock

Infectious Diseases of Humans

1991 • 5,181 citations

World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance

1992 • 1,621 citations

Evaluating treatment protocols to prevent antibiotic resistance

1997 • 495 citations

Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers.

1999 • 483 citations

Drug-Resistant Schistosomiasis: Resistance to Praziquantel and Oxamniquine Induced in Schistosoma Mansoni in Mice is Drug Specific

1994 • 470 citations

Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in β-tubulin isotype 1

1994 • 412 citations

Worm control and anthelmintic resistance: adventures with a model

1995 • 369 citations

Praziquantel

1983 • 347 citations

Characterization of Isolates of Schistosoma mansoni from Egyptian Villagers that Tolerate High Doses of Praziquantel

1996 • 316 citations

Efficacy and Side Effects of Praziquantel in an Epidemic Focus of Schistosoma mansoni

1995 • 305 citations

Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog1Note: Nucleotide sequence data reported in this paper have been submitted to the GenBank data base with the accession number AF 003908.1

1998 • 290 citations

Molecular mechanisms of drug resistance

1990 • 279 citations

Evaluation of Kato Thick-Smear Technique for Quantitative Diagnosis of Helminth Infections

1968 • 272 citations

Underestimation of Schistosoma mansoni prevalences

1992 • 271 citations

β-Tubulin Genes from the Parasitic NematodeHaemonchus contortusModulate Drug Resistance inCaenorhabditis elegans

1995 • 265 citations

Anthelmintic resistance: past, present and future

1999 • 251 citations

Antischistosomal drugs: Past, present … and future?

1995 • 250 citations

Assessment of the incidence of substandard drugs in developing countries

1997 • 228 citations

Failure of Mebendazole in Treatment of Human Hookworm Infections in the Southern Region of Mali

1997 • 218 citations

Population Biology of Parasitic Nematodes: Applications of Genetic Markers

1998 • 217 citations

Detecting benzimidazole resistance with faecal egg count reduction tests and in vitro assays

1989 • 217 citations

Control Strategies for Human Intestinal Nematode Infections

1999 • 216 citations

Day-to-Day Egg Count Fluctuation in Schistosoma mansoni Infection and its Operational Implications

1996 • 202 citations

Egg hatch as an in vitro assay of thiabendazole resistance in nematodes

1976 • 182 citations

How long before resistance makes it impossible to control some field strains of Haemonchus contortus in South Africa with any of the modern anthelmintics?

1997 • 179 citations

Short Report: Diminished Susceptibility to Praziquantel in a Senegal Isolate of Schistosoma mansoni

1995 • 171 citations

Haemonchus contortus: Selection at a Glutamate-Gated Chloride Channel Gene in Ivermectin- and Moxidectin-Selected Strains

1998 • 166 citations

The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: General overview

1996 • 161 citations

Failure of pyrantel in treatment of human hookworm infections (Ancylostoma duodenale) in the Kimberley region of North West Australia

1997 • 157 citations

Amino acid alterations in the benA (β‐tubulin) gene of Aspergillus nidulans that confer benomyl resistance

1992 • 156 citations

Chemotherapy of Nematode Infections of Veterinary Importance, with Special Reference to Drug Resistance

1995 • 152 citations

Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus

1998 • 149 citations

Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus.

1994 • 148 citations

Avermectin inhibition of larval development in Haemonchus contortus — Effects of ivermectin resistance

1995 • 147 citations

Modelling and forecasting

1999 • 142 citations

Quick Kato Smear for Field Quantification of Schistosoma Mansoni Eggs *

1980 • 140 citations

Epidemiology, immunology and chemotherapy of Schistosoma mansoni infections in a recently exposed community in Senegal.

1994 • 132 citations

Management of anthelmintic resistance: Inheritance of resistance and selection with persistent drugs

1996 • 129 citations

Praziquantel: An urgent and exciting challenge

1996 • 127 citations

Evaluating measures to control intestinal parasitic infections.

1992 • 126 citations

Quantitative variability of nematode egg counts in faeces: a study among rural Kenyans

1981 • 123 citations

Chemotherapy of Schistosomiasis: An Update

1998 • 121 citations

Anthelmintic resistance revisited: under-dosing, chemoprophylactic strategies, and mating probabilities

1999 • 121 citations

The African programme for onchocerciasis control: Preparing to launch

1995 • 114 citations

New genetic and practical implications of selection for anthelmintic resistance in parasitic nematodes

1995 • 109 citations

Epidemiology of Schistosoma mansoni Infection in a Recently Exposed Community in Northern Senegal

1993 • 109 citations

Ivermectin resistance

1993 • 107 citations

Avermectin\milbemycin resistance in trichostrongyloid nematodes

1998 • 107 citations

Sequences of β-tubulin cDNA from benzimidazole-susceptible and -resistant strains of Teladorsagia circumcincta, a nematode parasite of small ruminants

1996 • 103 citations

Haemonchus contortus: Sequence Heterogeneity of Internucleotide Binding Domains from P-Glycoproteinsand an Association with Avermectin/Milbemycin Resistance

1999 • 102 citations

Drug resistance in schistosomes

1993 • 101 citations

Quantitative diagnosis of Schistosoma infections by measurement of circulating antigens in serum and urine.

1994 • 100 citations

Efficacy of praziquantel against Schistosoma mansoni in northern Senegal

1998 • 99 citations

Anthelmintic resistance in nematode parasites of sheep: learning from the Australian experience

1995 • 97 citations

PCR diagnosis of benzimidazole-susceptibity or -resistance in natural populations of the small ruminant parasite, Teladorsagia circumcincta

1999 • 96 citations

Intensity of reinfection with Ascaris lumbricoides and its implications for parasite control

1992 • 94 citations

The control of schistosomiasis. Report of a WHO Expert Committee.

1985 • 92 citations

Worm burdens in schistosome infections

1996 • 91 citations

Therapeutic Evaluation of Two Different Dose Regimens of Praziquantel in a Recent Schistosoma mansoni Focus in Northern Senegal

1997 • 90 citations

A model for variations in single and repeated egg counts in schistosoma mansoni infections

1992 • 89 citations

Oxamniquine CuresSchistosoma mansoniInfection in a Focus in Which Cure Rates with Praziquantel Are Unusually Low

1997 • 87 citations

Schistosome resistance to praziquantel: Fact or artifact?

1996 • 85 citations

Can we deworm this wormy world?

1998 • 85 citations

Intraspecimen Fecal Egg Count Variation in Schistosoma mansoni Infection

1997 • 83 citations

Larval development test for detection of anthelmintic resistant nematodes

1988 • 83 citations

Schistosoma mansoni:Maturation Rate and Drug Susceptibility of Different Geographic Isolates

1997 • 80 citations

Trichostrongylus colubrifortnis and Ostertagia circumcincta resistant to levamisole, morantel tartrate and thiabendazole:occurrence of field strains

1979 • 78 citations

The disposition of antiparasitic drugs in relation to the development of resistance by parasites of livestock

1994 • 78 citations

Anthelmintic resistance in human helminths: Learning from the problems with worm control in livestock

1997 • 77 citations

Use of the egg hatch assay on sheep faecal samples for the detection of benzimidazole resistant nematodes

1989 • 77 citations

An International Initiative on Praziquantel Use

1998 • 75 citations

Anthelmintic resistance in goats in peninsular Malaysia

1994 • 71 citations

Comparison of the efficacy of mebendazole, albendazole and pyrantel in treatment of human hookworm infections in the Southern Region of Mali, West Africa

1999 • 70 citations

The role of drugs in the control of parasitic nematode infections: must we do without?

1997 • 68 citations

Micromotility meter: an instrument designed to evaluate the action of drugs on motility of larval and adult nematodes

1986 • 67 citations

Development of anthelmintic resistance in nematodes from sheep in Australia subjected to different treatment frequencies

1983 • 67 citations

The USAID/Government of Egypt's Schistosomiasis Research Project (SRP)

1998 • 66 citations

Use of praziquantel against schistosomiasis: a review of current status

1994 • 65 citations

Anthelmintic drug resistance in the UK

1989 • 64 citations

Schistosoma mansoni: Hycanthone/oxamniquine resistance is controlled by a single autosomal recessive gene

1992 • 63 citations

EFFECTS OF A PREVENTIVE AND SUPPRESSIVE CONTROL SCHEME ON THE DEVELOPMENT OF THIABENDAZOLE‐RESISTANCE IN OSTERTAGIA SPP

1982 • 62 citations

Laboratory Selection of Haemonchus contortus for Resistance to Ivermectin

1988 • 61 citations

Schistosomiasis control in the People's Republic of China

1997 • 60 citations

The problem of escalating resistance of Haemonchus contortus to the modern anthelmintics in South Africa.

1989 • 60 citations

Comparison of six in vitro tests in determining benzimidazole and levamisole resistance in Haemonchus contortus and Ostertagia circumcincta of sheep

1999 • 59 citations

Is Schistosomicidal Chemotherapy Sub-curative? Implications for Drug Resistance

1998 • 58 citations

Pharmacology of anthelmintic resistance

1996 • 58 citations

Genetic variation in parasitic nematodes and its implications

1994 • 57 citations

Pharmaceutical quality of anthelmintics sold in Kenya

1998 • 57 citations

The Development of Resistance to Anthelmintics: A Perspective with an Emphasis on the Antischistosomal Drug Praziquantel

1997 • 56 citations

Evidence of multiple mechanisms of avermectin resistance in Haemonchus contortus—comparison of selection protocols

1998 • 56 citations

Ivermectin Binding Sites in Sensitive and Resistant Haemonchus contortus

1994 • 55 citations

Characterization of an acetylcholine receptor gene of haemonchus contortus in relation to levamisole resistance1Note: Nucleotide sequence data reported in this paper are available in the GenBank™ database under accession No. U72490.1

1997 • 54 citations

Methodology and interpretation of parasitological surveillance of intestinal schistosomiasis in Maniema, Kivu Province, Zaire.

1985 • 54 citations

Schistosoma mansoni: Genetic Complementation Analysis Shows That Two Independent Hycanthone/Oxamniquine-Resistant Strains Are Mutated in the Same Gene

1993 • 53 citations

The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: Paraguay

1996 • 53 citations

The association between frequency of thiabendazole treatment and the development of resistance in field isolates of Ostertagia spp. of sheep

1984 • 51 citations

Beta-tubulin gene polymorphism and benzimidazole resistance in Trichostrongylus colubriformis

1996 • 50 citations

Alterations in cytochrome-c oxidase expression between praziquantel-resistant and susceptible strains of Schistosoma mansoni

1998 • 45 citations

Evolution of operational research studies and development of a national control strategy against intestinal helminths in Pemba Island, 1988-92.

1995 • 44 citations

Research note Use of P-glycoprotein gene probes to investigate anthelmintic resistance in Haemonchus contortus and comparison with Onchocerca volvulusfn1fn1Note: Sequence data reported in this paper are available in the GenBankTM database under the accession numbers U94401 (Haemonchus contortus) and U94399 and U94400 (Onchocerca volvulus).

1998 • 43 citations

Field trials of praziquantel and oxamniquine for the treatment of schistosomiasis mansoni in Burundi

1987 • 43 citations

The contribution of host-related factors to low cure rates of praziquantel for the treatment of Schistosoma mansoni in Senegal.

1999 • 41 citations

Suspected resistance of Ostertagia ostertagi in cattle to levamisole

1987 • 39 citations

Uncertainties in the epidemiology and control of schistosomiasis

1996 • 34 citations

Selection for high levamisole resistance in Haemonchus contortus monitored with an egg-hatch assay

1997 • 31 citations

Fluctuation of Schistosome Circulating antigen Levels in Urine of Individuals with Schistosoma mansoni Infection in Burundi

1996 • 31 citations

Drug resistance to schistosomicides and other anthelmintics of medical significance

1994 • 31 citations

Quality control in generic anthelmintics: Is it adequate?

1997 • 30 citations

Comparison of the sensitivity of different geographical races of Onchocerca volvulus microfilariae to ivermectin: studies in vitro

1994 • 30 citations

Impact of drug dosage and brand on bioavailability and efficacy of praziquantel

1995 • 28 citations

Treatment of mixed Oesophagostomum and hookworm infection: effect of albendazole, pyrantel pamoate, levamisole and thiabendazole

1993 • 24 citations

Control of Schistosoma mansoni and intestinal helminths: 8-year follow-up of an urban school programme in Bujumbura, Burundi

1994 • 24 citations

Chemotherapy of Human Nematodes: Learning from the Problems in Sheep

1995 • 24 citations

Cost and effectiveness of different approaches to schistosomiasis control in Africa.

1986 • 23 citations

Development and validation of an in vitro Trichostrongylus colubriformis motility assay

1987 • 22 citations

Prevalence of benzimidazole resistance of nematodes in sheep in The Netherlands

1987 • 22 citations

Reliability and reproducibility of the larval paralysis test as an in vitro method for the detection of anthelmintic resistance of nematodes against levamisole and morantel tartrate

1989 • 21 citations

Tubulin, resistance and worms

1995 • 20 citations

Use of arithmetic and geometric means in the calculation of anthelmintic efficacy

1997 • 19 citations

A survey of ovine parasite control practices in Tennessee

1992 • 18 citations

The nicotinic acetylcholine α-subunit gene tar-1 is located on the X chromosome but its coding sequence is not involved in levamisole resistance in an isolate of Trichostrongylus colubriformis

1997 • 14 citations

For the new millennium: control of helminth diseases throughout the world

1993 • 9 citations

Drugs

1994 • 8 citations

Benzimidazole resistance in nematodes on a dairy goat farm in Belgium.

1990 • 8 citations

Resistance of Onchocerca volvulus microfilariae to diethylcarbamazine.

1957 • 7 citations

Call for renewed drive against schistosomiasis

1998 • 2 citations