Drug resistance to schistosomicides and other anthelmintics of medical significance

The Crisis in Antibiotic Resistance

1992 • 2,815 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum

1990 • 594 citations

The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles

1988 • 548 citations

Schistosoma mansoni: Chemotherapy of infections of different ages

1986 • 352 citations

Treatment of Visceral Leishmaniasis with Pentavalent Antimony and Interferon Gamma

1990 • 313 citations

The biology of schistosomes; from genes to Latrines

1988 • 270 citations

Gene replacement in parasitic protozoa

1990 • 238 citations

The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response.

1987 • 192 citations

Praziquantel: mechanisms of anti-schistosomal activity

1985 • 185 citations

Mutations in 16S ribosomal RNA disrupt antibiotic-RNA interactions.

1989 • 163 citations

The development of anthelmintic resistance in ruminant livestock

1994 • 154 citations

Hycanthone: A Frameshift Mutagen

1971 • 150 citations

Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro

1986 • 131 citations

Schistosomiasis: Epidemiology, Treatment and Control

1983 • 126 citations

Experimental Studies on the Therapy of Schistosomiasis

1948 • 110 citations

Schistosoma mansoni: Reduced efficacy of chemotherapy in infected T-cell-deprived mice

1985 • 108 citations

Ivermectin resistance

1993 • 107 citations

Praziquantel: The enigmatic antiparasitic

1992 • 105 citations

A New, Active Metabolite of ‘Miracil D’

1965 • 105 citations

Drug resistance in schistosomes

1993 • 101 citations

Role of host antibody in the chemotherapeutic action of praziquantel against Schistosoma mansoni: identification of target antigens

1989 • 101 citations

Hycanthone Resistance: Development in Schistosoma mansoni

1971 • 97 citations

Detection of resistance to ivermectin in haemonchus contortus

1991 • 94 citations

The Chemotherapy of Schistosomiasis

1985 • 89 citations

AUSTRALIAN ADVANCES IN VETERINARY SCIENCE

1978 • 88 citations

THE SUCCESSFUL USE OF ANTIMONY IN BILHARZIOSIS

1918 • 81 citations

Differentiation of schistosomes by species, strain, and sex by using cloned DNA markers.

1984 • 80 citations

Estudo de uma cepa humana de Schistosoma mansoni resistente a agentes esquistossomicidas

1973 • 75 citations

Use of praziquantel in patients with schistosomiasis mansoni previously treated with oxamniquine and/or hycanthone: resistance of Schistosoma mansoni to schistosomicidal agents

1982 • 73 citations

The arrangement of ribosomal RNA genes in Schistosoma mansoni

1984 • 73 citations

Anti-schistosome chemotherapy enhanced by antibodies specific for a parasite esterase.

1988 • 72 citations

Schistosoma mansoni: Hycanthone/oxamniquine resistance is controlled by a single autosomal recessive gene

1992 • 63 citations

A New Series of 2-Aminomethyltetrahydroquinoline Derivatives displaying Schistosomicidal Activity in Rodents and Primates

1969 • 58 citations

Immunological involvement in the efficacy of praziquantel

1990 • 56 citations

Chemotherapy of ExperimentalSchistosoma MansoniInfections with a Nitro-Thiazole Derivative, CIBA 32,644-Ba

1964 • 51 citations

Studies on the Mode of Action of Oxamniquine and Related Schistosomicidal Drugs

1985 • 49 citations

Schistosoma mansoni:stage-dependent damage afterin vivotreatment with praziquantel

1990 • 48 citations

Post-Cercarial Development of Schistosoma mansoni in the Rabbit and Hamster after Intraperitoneal and Percutaneous Infection

1949 • 48 citations

The immune dependence of chemotherapy

1991 • 48 citations

Evidence for the mode of antischistosomal action of hycanthone

1985 • 42 citations

Sequence of a small subunit rRNA gene of Schistosoma mansoni and its use in phylogenetic analysis

1991 • 42 citations

A New Approach to Helminthiasis Control: the Use of an Organophosphorous Compound *

1962 • 41 citations

A genomic change associated with the development of resistance to hycanthone in Schistosoma mansoni

1989 • 40 citations

Susceptibility to Chemotherapeutic Agents of Strains of Schistosoma mansoni Isolated from Treated and Untreated Patients *

1980 • 38 citations

Solubilization and characterization of an angiotensin II binding protein from liver

1983 • 38 citations

Genomic Variability in Field Populations of Schistosoma mansoni in Brazil as Detected with a Ribosomal Gene Probe

1991 • 37 citations

Hycanthone Analogs: Dissociation of Mutagenic Effects from Antischistosomal Effects

1974 • 35 citations

Genetic Analysis of Hycanthone Resistance in Schistosoma Mansoni

1984 • 35 citations

Experimentally Produced Resistance of Schistosoma Mansoni to Hycanthone *

1977 • 35 citations

The immune-dependence of schistosomicidal chemotherapy: relative lack of efficacy of an antimonial in Schistosoma mansoni-infected mice deprived of their T-cells and the demonstration of drug-antiserum synergy.

1978 • 34 citations

Binding of oxamniquine to the DNA of schistosomes

1989 • 34 citations

Schistosoma mansoni: praziquantel-induced tegumental lesion exposes actin of surface spines and allows binding of actin depolymerizing factor, gelsolin

1992 • 30 citations

Hycanthone resistance in schistosomes correlates with the lack of an enzymatic activity which produces the covalent binding of hycanthone to parasite macromolecules

1992 • 29 citations

Chemotherapy and the immune response in parasitic infections

1985 • 29 citations

Characterization of a programmed alteration in an 18S ribosomal gene that accompanies the experimental induction of drug resistance in Schistosoma mansoni.

1991 • 28 citations

Infection Characteristics of Schistosoma japonicum in Mice and Relevance to the Assessment of Schistosome Vaccines

1991 • 27 citations

Drug resistance in Fasciola hepatica.

1990 • 27 citations

Researchers Fret Over Neglect Of 600 Million Patients

1992 • 24 citations

In vitro selection of drug resistant Schistosoma mansoni

1987 • 24 citations

Fasciola hepatica: Effects of diamfenetide free amine on in vitro physiology, biochemistry, and morphology

1983 • 24 citations

Mode of action of the schistosomicide Hycanthone: site of DNA alkylation

1990 • 23 citations

Cryopreservation of Schistosomules of Schistosoma Mansoni in Quantity *

1984 • 21 citations

Binding of tritiated hycanthone and hycanthone N-methylcarbamate to macromolecules of drug-sensitive and drug-resistant schistosomes

1988 • 21 citations

Malathion-resistant pediculosis capitis.

1972 • 19 citations

Efficacy of Metrifonate in Urinary Schistosomiasis: Comparison of Reduction of Schistosoma haematobium and S. mansoni Eggs *

1982 • 19 citations

Dynamic changes of DNA sequences in Schistosoma mansoni in the course of development

1990 • 19 citations

Failure to induce resistance of Schistosoma japonicum to praziquantel.

1990 • 18 citations

The antischistosomal activity of a chloroindazole analog of hycanthone in mice infected with Schistosoma mansoni.

1973 • 18 citations

Schistosoma mansoni: enhanced efficacy of Praziquantel treatment in immune mice

1989 • 18 citations

Persistence of Hepatic Fibrosis and Tissue Eggs Following Treatment of Schistosoma japonicum Infected Mice

1989 • 15 citations

Inhibition of Phosphoinositide Turnover by Praziquantel in Schistosoma mansoni

1992 • 14 citations

Drug susceptibility of geographic strains of Schistosoma japonicum.

1963 • 12 citations

Oxamniquine resistance inSchistosoma mansoni:fact or fiction?

1987 • 11 citations

Enzymatic differences between hycanthone-resistant and sensitive strains of Schistosoma mansoni

1987 • 7 citations

Recent laboratory investigations by Chinese workers on antischistosomal activities of praziquantel.

1991 • 7 citations

Immunity to Hymenolepis diminuta: unresponsiveness of the athymic nude mouse to infection

1976 • 4 citations