Haemonchus contortus: Selection at a Glutamate-Gated Chloride Channel Gene in Ivermectin- and Moxidectin-Selected Strains
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References (39)
BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER
1993 • 3,515 citations
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans
1994 • 716 citations
A point mutation in a Drosophila GABA receptor confers insecticide resistance
1993 • 552 citations
The GABAergic nervous system of Caenorhabditis elegans
1993 • 491 citations
avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans
1997 • 350 citations
Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog1Note: Nucleotide sequence data reported in this paper have been submitted to the GenBank data base with the accession number AF 003908.1
1998 • 290 citations
Haemonchus contortus: Ivermectin-Induced Paralysis of the Pharynx
1993 • 226 citations
The Mechanism of Action of Avermectins in Caenorhabditis Elegans: Correlation between Activation of Glutamate-Sensitive Chloride Current, Membrane Binding, and Biological Activity
1995 • 223 citations
Resistance of field strains of Haemonchus contortus to ivermectin, closantel, rafoxanide and the benzimidazoles in South Africa
1988 • 216 citations
The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex
1995 • 205 citations
Anthelmintic resistance in nematodes: Extent, recent understanding and future directions for control and research
1990 • 178 citations
Reversal of P-glycoprotein-associated multidrug resistance by ivermectin
1997 • 174 citations
Avermectin B1a, a paralyzing anthelmintic that affects interneurons and inhibitory motoneurons in Ascaris.
1980 • 164 citations
Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus.
1994 • 148 citations
The abamectin derivative ivermectin is a potent P-glycoprotein inhibitor
1996 • 124 citations
Two Populations of L-Glutamate Receptors on Locust Muscle Fibres
1973 • 119 citations
Tight genetic linkage between the kdr insecticide resistance trait and a voltage-sensitive sodium channel gene in the house fly.
1994 • 118 citations
Multiple resistance to ivermectin and oxfendazole in Cooperia species of cattle in New Zealand
1995 • 116 citations
UNUSUAL POPULATION GENETICS OF A PARASITIC NEMATODE: mtDNA VARIATION WITHIN AND AMONG POPULATIONS
1992 • 107 citations
Anthelmintic resistance by Haemonchus contortus to ivermectin in Brazil: a preliminary report
1989 • 96 citations
Molecular biology and electrophysiology of glutamategated chloride channels of invertebrates
1996 • 95 citations
Cholinergic receptor mutants of the nematode Caenorhabditis elegans
1987 • 92 citations
An electrophysiological preparation ofAscaris suumpharyngeal muscle reveals a glutamate-gated chloride channel sensitive to the avermectin analogue, milbemycin D
1996 • 91 citations
The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease.
1996 • 89 citations
Mutual resistance to avermectins and milbemycins: oral activity of ivermectin and moxidectin against ivermectin-resistant and susceptible nematodes
1993 • 87 citations
Demonstration of co-resistance of Haemonchus contortus to ivermectin and moxidectin
1993 • 83 citations
Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes.
1991 • 83 citations
An Amino Acid Substitution in the Pore Region of a Glutamate-gated Chloride Channel Enables the Coupling of Ligand Binding to Channel Gating
1996 • 76 citations
A survey of anthelmintic resistance in nematode parasites of goats in Denmark
1996 • 70 citations
Reporter Gene Constructs Suggest That the Caenorhabditis Elegans Avermectin Receptor β-Subunit is Expressed Solely in the Pharynx
1997 • 61 citations
Ivermectin Binding Sites in Sensitive and Resistant Haemonchus contortus
1994 • 55 citations
Ivermectin‐resistant Haemonchus contortus in Australia
1993 • 53 citations
Resistance by Haemonchus contortus to ivermectin in angora goats.
1990 • 52 citations
Unusual Population Genetics of a Parasitic Nematode: mtDNA Variation Within and among Populations
1992 • 50 citations
Glutamate-gated inhibitory currents of central pattern generator neurons in the lobster stomatogastric ganglion
1995 • 47 citations
Cloning of a putative inhibitory amino acid receptor subunit from the parasitic nematode Haemonchus contortus.
1994 • 42 citations
Cloning of a cDNA encoding phosphofructokinase from Haemonchus contortus
1991 • 30 citations
Ivermectin-moxidectin side resistance by Ostertagia species isolated from goats and passaged to sheep
1996 • 26 citations
The glutamate-induced chloride current in Aplysia neurones lacks pharmacological properties seen for excitatory responses to glutamate
1988 • 24 citations