Stimulated kidney tubular epithelial cells express membrane associated and secreted TNFα

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.

1986 • 1,439 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus.

1989 • 785 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Structure of tumour necrosis factor

1989 • 512 citations

A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity

1989 • 442 citations

Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides.

1988 • 397 citations

Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.

1985 • 394 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Human vascular smooth muscle cells. Target for and source of tumor necrosis factor.

1989 • 333 citations

Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis.

1988 • 321 citations

Purification and biologic characterization of a specific tumor necrosis factor α inhibitor

1989 • 294 citations

Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression

1985 • 266 citations

Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury.

1989 • 255 citations

MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells

1990 • 246 citations

Inhibition of mixed lymphocyte response by a rat monoclonal antibody to a novel murine lymphocyte activation antigen (MALA-2).

1985 • 229 citations

Production of tumor necrosis factor by rat mesangial cells in response to bacterial lipopolysaccharide

1989 • 220 citations

Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection.

1987 • 206 citations

Assays for tumour necrosis factor and related cytokines

1989 • 204 citations

Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune murine lupus nephritis.

1990 • 199 citations

A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells.

1990 • 133 citations

Novel and enhanced IL-1 gene expression in autoimmune mice with lupus.

1988 • 126 citations

Molecular mechanisms in down-regulation of tumor necrosis factor expression.

1990 • 120 citations

Tumor necrosis factor mRNA localized to Paneth cells of normal murine intestinal epithelium by in situ hybridization.

1990 • 111 citations

Tumor necrosis factor increases the number of epidermal growth factor receptors on human fibroblasts.

1987 • 109 citations

Synergistic and overlapping activities of tumor necrosis factor-alpha and IL-1.

1988 • 102 citations

Tumor necrosis factor expression in human epithelial tumor cell lines.

1988 • 102 citations

Immunohistochemical demonstration of cytoplasmic and membrane-associated tumor necrosis factor in murine macrophages.

1988 • 101 citations

Mesangial cell accessory functions: Mediation by intercellular adhesion molecule-1

1990 • 97 citations

Tumor necrosis factor and lymphotoxin gene expression in human tumor cell lines.

1988 • 83 citations

Trace levels of bacterial lipopolysaccharide prevent interferon-gamma or tumor necrosis factor-alpha from enhancing mouse peritoneal macrophage respiratory burst capacity.

1987 • 75 citations

Tumor necrosis factor-alpha as a proliferative signal for an IL-2-dependent T cell line: strict species specificity of action.

1989 • 74 citations

Induction of interleukin 2 receptor (TAC) by tumor necrosis factor in YT cells.

1987 • 69 citations

Identification and characterization of a membrane-bound cytotoxin of murine cytolytic lymphocytes that is related to tumor necrosis factor/cachectin.

1989 • 65 citations

Both interleukin 1 and tumor necrosis factor enhance thymocyte proliferation

1988 • 56 citations

Interleukin-6 production by murine macrophage cell lines P388D1 and J774A.1: Stimulation requirements and kinetics

1990 • 48 citations

Induction of synthesis of tumor necrosis factor in human and murine cell lines by exogenous recombinant human tumor necrosis factor.

1988 • 43 citations

Detection of IL-1 alpha and IL-1 beta in the supernatants of paraformaldehyde-treated human monocytes. Evidence against a membrane form of IL-1.

1990 • 39 citations

Cycloheximide, an inhibitor of protein synthesis, prevents ?-interferon-induced expression of class II mRNA in a macrophage cell line

1988 • 26 citations

T Cell recognition of epithelial self

1989 • 24 citations

Prostaglandins and renin release in vitro

1981 • 18 citations