Protein Disulphide Isomerase and a Lumenal Cyclophilin-Type Peptidyl Prolyl Cis-Trans Isomerase are in Transient Contact with Secretory Proteins During Late Stages of Translocation

Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 644 citations

A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation

1992 • 450 citations

A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum.

1987 • 418 citations

Sec61p and BiP directly facilitate polypeptide translocation into the ER

1992 • 370 citations

Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex

1991 • 359 citations

Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP–binding domains

1989 • 357 citations

Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast.

1989 • 339 citations

Defective co-translational formation of disulphide bonds in protein disulphide-isomerase-deficient microsomes

1988 • 330 citations

A protein of the endoplasmic reticulum involved early in polypeptide translocation

1992 • 322 citations

Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.

1991 • 319 citations

The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide

1989 • 293 citations

A signal sequence receptor in the endoplasmic reticulum membrane

1987 • 291 citations

The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation

1993 • 286 citations

Evolutionary conservation of components of the protein translocation complex

1994 • 283 citations

Cyclosporin A, FK506 and rapamycin: more than just immunosuppression

1993 • 259 citations

Isomerase and Chaperone Activity of Prolyl Isomerase in the Folding of Carbonic Anhydrase

1992 • 206 citations

The essential function of yeast protein disulfide isomerase does not reside in its isomerase activity

1993 • 201 citations

Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein.

1986 • 199 citations

Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation

1993 • 183 citations

GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation

1993 • 183 citations

Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel.

1989 • 167 citations

Structural properties of homogeneous protein disulphide-isomerase from bovine liver purified by a rapid high-yielding procedure

1983 • 148 citations

Membrane glycoprotein folding, oligomerization and intracellular transport: effects of dithiothreitol in living cells.

1993 • 139 citations

Yeast Sec proteins interact with polypeptides traversing the endoplasmic reticulum membrane

1992 • 138 citations

The bonds that tie: Catalyzed disulfide bond formation

1993 • 134 citations

Cell-free synthesis and assembly of prolyl 4-hydroxylase: the role of the beta-subunit (PDI) in preventing misfolding and aggregation of the alpha-subunit.

1993 • 112 citations

Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion.

1993 • 109 citations

A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation.

1991 • 109 citations

The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER.

1991 • 104 citations

Access of proteinase K to partially translocated nascent polypeptides in intact and detergent-solubilized membranes.

1989 • 88 citations

A microsomal protein is involved in ATP-dependent transport of presecretory proteins into mammalian microsomes.

1991 • 77 citations

Studies on the formation of intrachain disulphide bonds in newly biosynthesised bovine prolactin

1985 • 42 citations

The characterization of a cyclophilin-type peptidyl prolyl cis-trans-isomerase from the endoplasmic-reticulum lumen

1994 • 32 citations

Cotranslational glycosylation of proteins in systems depleted of protein disulphide isomerase.

1990 • 31 citations

Peptidyl prolyl cis-trans-isomerase activity associated with the lumen of the endoplasmic reticulum

1994 • 30 citations

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