CD34+ Hematopoietic Progenitors From Human Cord Blood Differentiate Along Two Independent Dendritic Cell Pathways in Response to Granulocyte-Macrophage Colony-Stimulating Factor Plus Tumor Necrosis Factor α: II. Functional Analysis

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.

1996 • 962 citations

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

1995 • 687 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A.

1992 • 641 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.

1990 • 543 citations

Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo.

1993 • 487 citations

Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow.

1992 • 452 citations

Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow.

1993 • 428 citations

Fas ligation induces apoptosis of CD40-activated human B lymphocytes.

1995 • 402 citations

Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch.

1996 • 360 citations

Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha.

1995 • 350 citations

B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.

1994 • 347 citations

Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells.

1995 • 324 citations

Dendritic cells capable of stimulating T cells in germinal centres

1996 • 309 citations

The endocytic activity of dendritic cells.

1995 • 308 citations

Dendritic Cells Enhance Growth and Differentiation of CD40-activated B Lymphocytes

1997 • 301 citations

Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo

1994 • 300 citations

Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo.

1993 • 284 citations

Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen‐specific T cells

1993 • 276 citations

TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages

1992 • 257 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions.

1993 • 250 citations

Activation of human B lymphocytes through CD40 and interleukin 4

1989 • 227 citations

Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo.

1992 • 215 citations

Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells

1994 • 205 citations

Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage.

1989 • 196 citations

Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man.

1983 • 185 citations

Protein-Specific Helper T-Lymphocyte Formation Initiated by Dendritic Cells

1985 • 181 citations

Clustering of dendritic cells, helper T lymphocytes, and histocompatible B cells during primary antibody responses in vitro.

1984 • 180 citations

Dendritic cells from mouse bone marrow: In vitro differentiation using low doses of recombinant granulocyte-macrophage colony-stimulating factor

1992 • 179 citations

Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells.

1986 • 174 citations

Tumor necrosis factor-alpha strongly potentiates interleukin-3 and granulocyte-macrophage colony-stimulating factor-induced proliferation of human CD34+ hematopoietic progenitor cells

1990 • 171 citations

Lymph‐Borne Dendritic Leucocytes do Not Recirculate, but Enter the Lymph Node Paracortex to Become Interdigitating Cells

1988 • 145 citations

Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines.

1995 • 144 citations

Human recombinant IL-4 induces activated B lymphocytes to produce IgG and IgM.

1988 • 119 citations

The regulation of T cell-dependent antibody formation in vitro by CD40 ligand and IL-2.

1993 • 97 citations

Potentiation of early hematopoiesis by tumor necrosis factor-alpha is followed by inhibition of granulopoietic differentiation and proliferation

1991 • 90 citations

IL-4 and IL-2 upregulate the expression of antigen B7, the B cell counterstructure to T cell CD28: an amplification mechanism for T-B cell interactions

1991 • 85 citations

Analysis of IL-2, IL-4, and IFN-gamma-producing cells in situ during immune responses to protein antigens.

1993 • 77 citations

Two populations of splenic dendritic cells detected with M342, a new monoclonal to an intracellular antigen of interdigitating dendritic cells and some B lymphocytes

1992 • 76 citations

Functional characteristics of the veiled cells in afferent lymph from the rat intestine.

1986 • 65 citations

Tumor necrosis factor alpha cooperates with interleukin 3 in the recruitment of a primitive subset of human CD34+ progenitors.

1993 • 50 citations

Immunohistochemical detection of co-localizing cytokine and antibody producing cells in the extrafollicular area of human palatine tonsils

1993 • 41 citations

Enhancement of antibody response by mouse dendritic cells pulsed with tobacco mosaic virus or with rabbit antiidiotypic antibodies raised against a private rabbit idiotype.

1985 • 37 citations

Comparing macrophages and dendritic leukocytes as antigen‐presenting cells for humoral responses in vivo by antigen targeting

1994 • 30 citations

T-independent and T-dependent B lymphoblasts: helper T cells prime for interleukin 2-induced growth and secretion of immunoglobulins that utilize downstream heavy chains.

1991 • 20 citations