Building a Metal-Responsive Promoter with Synthetic Regulatory Elements

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene

1982 • 1,406 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

1984 • 729 citations

DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo

1983 • 692 citations

The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus

1983 • 619 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit β-globin gene in mouse 3T6 cells

1983 • 596 citations

The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene

1980 • 556 citations

A drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene

1984 • 534 citations

Two protein-binding sites in chromatin implicated in the activation of heat-shock genes

1984 • 474 citations

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

1984 • 424 citations

Chromatin assembly in Xenopus oocytes: In vivo studies

1984 • 404 citations

A synthetic heat-shock promoter element confers heat-inducibility on the herpes simplex virus thymidine kinase gene.

1982 • 333 citations

Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids

1984 • 331 citations

Activating protein factor binds in vitro to upstream control sequences in heat shock gene chromatin

1984 • 329 citations

Structure of mouse metallothionein-I gene and its mRNA

1981 • 301 citations

The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements

1983 • 299 citations

Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids

1981 • 284 citations

Regulation of metallothionein–thymidine kinase fusion plasmids injected into mouse eggs

1982 • 283 citations

Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding

1984 • 281 citations

The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence

1984 • 272 citations

The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells

1982 • 265 citations

Functional relationships between transcriptional control signals of the thymidine kinase gene of herpes simplex virus

1982 • 253 citations

A model for chromatin based upon two symmetrically paired half-nucleosomes

1976 • 245 citations

Chromatin assembly in Xenopus oocytes: In vitro studies

1984 • 230 citations

Upstream elements necessary for optimal function of the hsp 70 promoter in transformed flies

1984 • 213 citations

Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5′-flanking DNA

1984 • 195 citations

Preferential binding of estrogen-receptor complex to a region containing the estrogen-dependent hypomethylation site preceding the chicken vitellogenin II gene.

1984 • 184 citations

Duplicated heavy metal control sequences of the mouse metallothionein-I gene.

1984 • 167 citations

SV40 DNA transfection of cells in suspension: analysis of the efficiency of transcription and translation of T-antigen

1981 • 161 citations

Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.

1984 • 153 citations

Simultaneous rapid chemical synthesis of over one hundred oligonucleotides on a microscale

1984 • 115 citations

Competition for cellular factors that activate metallothionein gene transcription

1984 • 107 citations

Expression of Bacterial β-Galactosidase in Animal Cells

1982 • 79 citations

Assembly of transcriptionally active chromatin in Xenopus oocytes requires specific DNA binding factors

1984 • 77 citations

Effect of methylation on expression of microinjected genes.

1982 • 61 citations

Transfer and expression of eukaryotic genes

1987 • 21 citations

Transcriptional Enhancement by Specific Regulatory Protein – DNA Complexes

1984 • 9 citations