A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

BMDP Statistical Software 1981

1982 • 2,365 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene

1982 • 1,406 citations

A regulatory upstream promoter element in the Drosophila Hsp 70 heat-shock gene

1982 • 1,038 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region

1983 • 700 citations

Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice

1983 • 699 citations

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: Identification of an upstream control region

1981 • 646 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring

1982 • 379 citations

Regulation, linkage, and sequence of mouse metallothionein I and II genes.

1984 • 335 citations

Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids

1984 • 331 citations

Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids

1981 • 284 citations

Regulation of metallothionein–thymidine kinase fusion plasmids injected into mouse eggs

1982 • 283 citations

The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence

1984 • 272 citations

The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells

1982 • 265 citations

The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter

1983 • 241 citations

Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae.

1983 • 231 citations

Glucocorticoid regulation of metallothionein-I mRNA synthesis in cultured mouse cells.

1981 • 211 citations

Isolation and characterization of the mouse metallothionein-I gene.

1980 • 210 citations

Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5′-flanking DNA

1984 • 195 citations

Expression of Bacterial β-Galactosidase in Animal Cells

1982 • 177 citations

Regulation of a metallothionein-growth hormone hybrid gene in bovine papilloma virus.

1983 • 168 citations

Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.

1984 • 153 citations

Induction of metallothionein-I mRNA in cultured cells by heavy metals and iodoacetate: evidence for gratuitous inducers.

1984 • 112 citations

Regulation, Linkage, and Sequence of Mouse Metallothionein I and II Genes

1984 • 96 citations

Expression and regulation of a human metallothionein gene carried on an autonomously replicating shuttle vector.

1983 • 94 citations

Regulation in vivo of a cloned mammalian gene: cadmium induces the transcription of a mouse metallothionein gene in SV40 vectors.

1982 • 82 citations

Expression of Bacterial β-Galactosidase in Animal Cells

1982 • 79 citations

Induction of Metallothionein in HeLa Cells by Dexamethasone and Zinc

1981 • 63 citations

Induction of Metallothionein-I mRNA in Cultured Cells by Heavy Metals and Iodoacetate: Evidence for Gratuitous Inducers

1984 • 32 citations