Elf-1 Binds to a Critical Element in a Second CD4 Enhancer

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

A new method for sequencing DNA.

1977 • 7,941 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.

1987 • 767 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

1990 • 507 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

Molecular Biology and Function of CD4 and CD8

1989 • 388 citations

Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif.

1992 • 381 citations

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

1991 • 364 citations

The Developmental Biology of T Lymphocytes

1988 • 300 citations

The Structure of the CD4 and CD8 Genes

1987 • 276 citations

Structural arrangements of transcription control domains within the 5'-untranslated leader regions of the HIV-1 and HIV-2 promoters.

1988 • 271 citations

Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage

1988 • 265 citations

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

1982 • 252 citations

Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence

1989 • 243 citations

Sequence-Specific Binding of Human Ets-1 to the T Cell Receptor α Gene Enhancer

1990 • 229 citations

Self-reactive γδ T cells are eliminated in the thymus

1990 • 221 citations

Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein

1993 • 220 citations

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

1993 • 201 citations

Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment

1988 • 197 citations

Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element.

1988 • 185 citations

Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1.

1993 • 180 citations

A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.

1991 • 178 citations

Evolutionarily conserved Ets family members display distinct DNA binding specificities.

1992 • 175 citations

Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin

1992 • 162 citations

Expression of ets genes in mouse thymocyte subsets and T cells.

1989 • 128 citations

A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells

1992 • 113 citations

Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins.

1993 • 111 citations

Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter.

1992 • 109 citations

The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.

1991 • 105 citations

Transcriptional and post-transcriptional regulation of TcR, CD4 and CD8 gene expression during activation of normal human T lymphocytes.

1990 • 88 citations

Role of CD4 in thymocyte selection and maturation.

1989 • 88 citations

Post-Transcriptional Regulation of Early T Cell Development by T Cell Receptor Signals

1992 • 83 citations

Molecular regulation of the human IL-3 gene: inducible T cell-restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites.

1993 • 80 citations

Cooperative binding of Ets-1 and core binding factor to DNA

1994 • 72 citations

Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes: analysis by antibody blocking and selective trypsinization.

1982 • 72 citations

The regulation of human globin gene switching

1993 • 62 citations

Functional GATA-3 binding sites within murine CD8 alpha upstream regulatory sequences.

1993 • 56 citations

Human T cell transcription factor GATA-3 stimulates HIV-1 expression

1993 • 53 citations

Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer.

1993 • 46 citations

Activation of the human T-cell leukemia virus type I enhancer is mediated by binding sites for Elf-1 and the pets factor

1993 • 41 citations

Alpha/beta T-cell antigen receptor gene and protein expression occurs at early stages of thymocyte differentiation.

1988 • 30 citations

Effect of gene dosage on cell-surface expression of Thy-1 antigen in somatic cell hybrids between Thy-1− abelson-leukemia-virus induced lymphomas and Thy-1+ mouse lymphomas

1981 • 24 citations

T cell-specific protein-DNA interactions occurring at the CD4 locus: identification of possible transcriptional control elements of the murine CD4 gene

1992 • 22 citations

Mutational Analysis of the Structure and Function of the CD4 Protein

1989 • 15 citations