THE EOSINOPHIL

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response

2000 • 1,834 citations

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial

2002 • 1,726 citations

A Tyrosine Kinase Created by Fusion of thePDGFRAandFIP1L1Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

2003 • 1,683 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

The Molecular Biology of Leukocyte Chemoattractant Receptors

1994 • 1,224 citations

Mast-Cell Infiltration of Airway Smooth Muscle in Asthma

2002 • 1,219 citations

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

2001 • 1,072 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of asthma

1990 • 916 citations

Eosinophilic gastrointestinal disorders (EGID)☆

2004 • 891 citations

A Critical Role for Eosinophils in Allergic Airways Remodeling

2004 • 851 citations

The Eosinophilic Leukocyte: Structure and Function

1986 • 828 citations

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.

1994 • 822 citations

Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation

2004 • 809 citations

Eosinophilia

1998 • 802 citations

Interleukin-5, eosinophils, and disease

1992 • 771 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Regulation of B Lymphocyte and Macrophage Development by Graded Expression of PU.1

2000 • 712 citations

Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils

2004 • 701 citations

Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.

1995 • 657 citations

An etiological role for aeroallergens and eosinophils in experimental esophagitis

2001 • 630 citations

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.

1996 • 626 citations

IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

1996 • 595 citations

Cytotoxic Properties of the Eosinophil Major Basic Protein

1979 • 595 citations

Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo

2002 • 581 citations

Eosinophilia in transgenic mice expressing interleukin 5.

1990 • 579 citations

Cloning, expression, and characterization of the human eosinophil eotaxin receptor.

1996 • 561 citations

The Coordinated Action of CC Chemokines in the Lung Orchestrates Allergic Inflammation and Airway Hyperresponsiveness

1998 • 546 citations

An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4

1992 • 540 citations

Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia

1997 • 537 citations

Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma

1997 • 527 citations

Effect of SCH55700, a Humanized Anti-Human Interleukin-5 Antibody, in Severe Persistent Asthma

2003 • 498 citations

Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors.

1996 • 436 citations

Postnatal mammary gland development requires macrophages and eosinophils

2000 • 429 citations

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

1998 • 425 citations

Type 2 Immunity Reflects Orchestrated Recruitment of Cells Committed to IL-4 Production

2004 • 422 citations

Mechanism of membrane damage mediated by human eosinophil cationic protein

1986 • 415 citations

Fundamental signals that regulate eosinophil homing to the gastrointestinal tract

1999 • 393 citations

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness

2002 • 385 citations

Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism1 1The authors thank Andrea Lippelman for editorial assistance; Drs. Fred Finkelman, Eric Brandt, Simon Hogan, and Paul Foster for helpful discussions and/or reagents; Drs. James and Nancy Lee (Mayo Clinic, Scottsdale, AZ) for the generous supply of anti-MBP; Dr. Debra Donaldson (Wyeth Research, Cambridge, MA) for the generous supply of recombinant IL-13; and Klaus Matthaei (Australian …

2003 • 369 citations

Effects of an antibody to interleukin-5 in a monkey model of asthma.

1995 • 335 citations

Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor.

1993 • 332 citations

Chemokines in asthma: Cooperative interaction between chemokines and IL-13

2003 • 332 citations

Lymph node trafficking and antigen presentation by endobronchial eosinophils

2000 • 326 citations

Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue.

1994 • 312 citations

Treatment of hypereosinophilic syndrome with imatinib mesilate

2002 • 310 citations

Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.

1991 • 303 citations

Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis

2003 • 301 citations

IL‐5‐induced airway eosinophilia – the key to asthma?

2001 • 301 citations

A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation

2001 • 300 citations

Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.

1986 • 287 citations

Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease

1999 • 284 citations

Eotaxin is required for the baseline level of tissue eosinophils

1998 • 282 citations

Eosinophils Are a Major Source of Nitric Oxide-Derived Oxidants in Severe Asthma: Characterization of Pathways Available to Eosinophils for Generating Reactive Nitrogen Species

2001 • 281 citations

Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens

2001 • 279 citations

A Novel Human CC Chemokine, Eotaxin-3, Which Is Expressed in IL-4-Stimulated Vascular Endothelial Cells, Exhibits Potent Activity Toward Eosinophils

1999 • 269 citations

Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization.

1997 • 269 citations

Cooperative and Antagonistic Interplay between PU.1 and GATA-2 in the Specification of Myeloid Cell Fates

2002 • 268 citations

Intrinsic Defect in T Cell Production of Interleukin (IL)-13 in the Absence of Both IL-5 and Eotaxin Precludes the Development of Eosinophilia and Airways Hyperreactivity in Experimental Asthma

2002 • 265 citations

Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse.

1990 • 263 citations

Allergic Eosinophil-rich Inflammation Develops in Lungs and Airways of B Cell–deficient Mice

1997 • 257 citations

Eosinophil Peroxidase Nitrates Protein Tyrosyl Residues

1999 • 257 citations

The role of adhesion molecules in human eosinophil and basophil recruitment

1994 • 243 citations

Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic protein.

1986 • 242 citations

The Eotaxin Chemokines and CCR3 Are Fundamental Regulators of Allergen-Induced Pulmonary Eosinophilia

2005 • 241 citations

Eotaxin and eosinophil recruitment: implications for human disease

2000 • 239 citations

Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies.

1997 • 235 citations

Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome.

1989 • 234 citations

Eotaxin (CCL11) and Eotaxin-2 (CCL24) Induce Recruitment of Eosinophils, Basophils, Neutrophils, and Macrophages As Well As Features of Early- and Late-Phase Allergic Reactions Following Cutaneous Injection in Human Atopic and Nonatopic Volunteers

2002 • 233 citations

Stimulation of basophil and rat mast cell histamine release by eosinophil granule-derived cationic proteins.

1984 • 227 citations

Elemental signals regulating eosinophil accumulation in the lung

2001 • 225 citations

Eosinophils Promote Allergic Disease of the Lung by Regulating CD4+ Th2 Lymphocyte Function

2001 • 220 citations

The Role of Eosinophils in Parasitic Helminth Infections: Insights from Genetically Modified Mice

2000 • 214 citations

Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists.

1990 • 213 citations

The trials and tribulations of IL-5, eosinophils, and allergic asthma

2001 • 209 citations

Essential and Instructive Roles of GATA Factors in Eosinophil Development

2002 • 207 citations

Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development

2002 • 205 citations

The Eosinophil in Health and Disease.

1981 • 204 citations

Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung.

1995 • 204 citations

Cutting Edge: Human Eosinophils Regulate T Cell Subset Selection through Indoleamine 2,3-Dioxygenase

2004 • 203 citations

Interleukin-5–producing CD4⁺ T Cells Play a Pivotal Role in Aeroallergen-induced Eosinophilia, Bronchial Hyperreactivity, and Lung Damage in Mice

1998 • 200 citations

The effects of glucocorticoids on human eosinophils

1994 • 200 citations

Nerve growth factor is preformed in and activates human peripheral blood eosinophils

1998 • 199 citations

Bltr Mediates Leukotriene B4–Induced Chemotaxis and Adhesion and Plays a Dominant Role in Eosinophil Accumulation in a Murine Model of Peritonitis

2000 • 198 citations

Helper T cells regulate type-2 innate immunity in vivo

2002 • 195 citations

IDENTIFICATION OF A HISTAMINE H₄RECEPTOR ON HUMAN EOSINOPHILS—ROLE IN EOSINOPHIL CHEMOTAXIS

2002 • 194 citations

Role of high molecular weight seminal vesicle proteins in eliciting the uterine inflammatory response to semen in mice

1996 • 191 citations

Immunobiology of Eosinophils

1984 • 191 citations

Activation and distribution of inflammatory cells in the mouse uterus during the preimplantation period.

1992 • 190 citations

Inhibition of human interleukin‐13‐induced respiratory and oesophageal inflammation by anti‐human‐interleukin‐13 antibody (CAT‐354)

2005 • 178 citations

A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo.

1993 • 177 citations

Murine Eotaxin-2: A Constitutive Eosinophil Chemokine Induced by Allergen Challenge and IL-4 Overexpression

2000 • 173 citations

Ovalbumin Sensitization Changes the Inflammatory Response to Subsequent Parainfluenza Infection

1999 • 170 citations

Murine eosinophil differentiation factor. An eosinophil-specific colony-stimulating factor with activity for human cells.

1986 • 170 citations

Eosinophils function as antigen-presenting cells

2004 • 161 citations

Antibody to very late activation antigen 4 prevents antigen-induced bronchial hyperreactivity and cellular infiltration in the guinea pig airways.

1994 • 161 citations

Effects of nerve growth factor on rat peritoneal mast cells. Survival promotion and immediate-early gene induction.

1994 • 153 citations

Identification of a Cooperative Mechanism Involving Interleukin-13 and Eotaxin-2 in Experimental Allergic Lung Inflammation

2005 • 150 citations

Eosinophils: structure and functions

1994 • 148 citations

Toxic effects of human eosinophil products on isolated rat heart cells in vitro

1982 • 147 citations

Bronchodilation with a Potent and Selective Leukotriene D₄(LTD₄) Receptor Antagonist (MK-571) in Patients with Asthma

1992 • 145 citations

Interleukin-13 but Not Interleukin-4 Prolongs Eosinophil Survival and Induces Eosinophil Chemotaxis.

1997 • 141 citations

The Eosinophil and its Role in Immunity to Helminth Infection

1977 • 141 citations

Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration.

1993 • 137 citations

Rapid Mobilization of Intracellularly Stored RANTES in Response to Interferon-γ in Human Eosinophils

1999 • 134 citations

Eosinophils Cocultured with Endothelial Cells Have Increased Survival and Functional Properties

1987 • 133 citations

A controlled trial of the effect of the 5-lipoxygenase inhibitor, zileuton, on lung inflammation produced by segmental antigen challenge in human beings

1996 • 133 citations

Distinct C/EBP functions are required for eosinophil lineage commitment and maturation

1998 • 125 citations

Making Eosinophils Through Subtle Shifts in Transcription Factor Expression

2002 • 125 citations

Autocrine interaction between IL-5 and IL-1β mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle

1999 • 122 citations

Determination of the Number and Distribution of Macrophages, Lymphocytes, and Granulocytes in the Mouse Uterus From Mating Through Implantation

1991 • 122 citations

CD11c+ Eosinophils in the Murine Thymus: Developmental Regulation and Recruitment upon MHC Class I-Restricted Thymocyte Deletion

2000 • 120 citations

Eosinophil Major Basic Protein-1 Does Not Contribute to Allergen-Induced Airway Pathologies in Mouse Models of Asthma

2000 • 120 citations

Differential Regulation of Epithelial-Derived C-C Chemokine Expression by IL-4 and the Glucocorticoid Budesonide

1999 • 118 citations

The cellular biology of eosinophil eicosanoid formation and function

2002 • 117 citations

Gastrointestinal Eosinophils in Health and Disease

2001 • 116 citations

Novel Combinatorial Interactions of GATA-1, PU.1, and C/EBPε Isoforms Regulate Transcription of the Gene Encoding Eosinophil Granule Major Basic Protein

2002 • 115 citations

Eosinophils Bind Rhinovirus and Activate Virus-Specific T Cells

1998 • 112 citations

Basophils Initiate IL-4 Production during a Memory T-dependent Response

2004 • 109 citations

Eosinophil recruitment to the airway nerves

2001 • 107 citations

Interleukin‐5 and eosinophils induce airway damage and bronchial hyperreactivity during allergic airway inflammation in BALB/c mice

1997 • 107 citations

Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology

2003 • 101 citations

Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate.

1995 • 101 citations

The injurious effect of eosinophil peroxidase, hydrogen peroxide, and halides on pneumocytes in vitro

1987 • 101 citations

Eosinophil Cytokines

2000 • 99 citations

β7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection

2000 • 98 citations

Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor.

1988 • 98 citations

Inhibitory effect of cetirizine on the bronchial eosinophil recruitment induced by allergen inhalation challenge in allergic patients with asthma

1992 • 97 citations

Enterocyte Expression of the Eotaxin and Interleukin-5 Transgenes Induces Compartmentalized Dysregulation of Eosinophil Trafficking

2002 • 95 citations

Nerve Growth Factor Induces the Expression of Certain Cytokine Genes and bcl-2 in Mast Cells

1996 • 94 citations

The eosinophil: A cytokine-producing cell?

1996 • 93 citations

Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions

1999 • 93 citations

No audible wheezing

2005 • 91 citations

Treatment of asthma with nebulized lidocaine: A randomized, placebo-controlled study☆

2004 • 86 citations

Expression of the Chemokine Eotaxin and Its Receptor, CCR3, in Human Endometrium1

2000 • 85 citations

Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics

2003 • 84 citations

CCR3 Is Required for Tissue Eosinophilia and Larval Cytotoxicity After Infection withTrichinella spiralis

2002 • 84 citations

Eosinophils express a functional receptor for interferon alpha: inhibitory role of interferon alpha on the release of mediators

1996 • 84 citations

Airway Eosinophils Accumulate in the Mediastinal Lymph Nodes but Lack Antigen-Presenting Potential for Naive T Cells

2003 • 83 citations

The FIP1L1-PDGFR?? kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia

2003 • 81 citations

Human eosinophils induce histamine release from antigen-activated rat peritoneal mast cells: A possible role for mast cells in late-phase allergic reactions

2001 • 79 citations

Murine B1 B Cells Require IL-5 for Optimal T Cell-Dependent Activation

2001 • 76 citations

Inhibition of Pulmonary Eosinophilia and Hyperreactivity by Antibodies to lnterleukin-5

1995 • 68 citations

Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation

2002 • 66 citations

Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis

2002 • 63 citations

Eosinophils in acute cellular rejection in liver allografts

1998 • 59 citations

Variant eotaxin: Its effects on the asthma phenotype

2001 • 51 citations

Eotaxin‐1‐regulated eosinophils have a critical role in innate immunity against experimental Brugia malayi infection

2004 • 50 citations

Peyer's patch eosinophils: identification, characterization, and regulation by mucosal allergen exposure, interleukin-5, and eotaxin

2000 • 49 citations

Sulfonylureas Inhibit Cytokine-Induced Eosinophil Survival and Activation

1998 • 47 citations

CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism

2005 • 45 citations

Diverse Effects of Eosinophil Cationic Granule Proteins on IMR-32 Nerve Cell Signaling and Survival

2005 • 37 citations

Interleukin-5 Transgene Expression and Eosinophilia Are Associated with Retarded Mammary Gland Development in Mice1

2003 • 35 citations

EliCell: a gel-phase dual antibody capture and detection assay to measure cytokine release from eosinophils

2000 • 34 citations

Analysis of the CC chemokine receptor 3 gene reveals a complex 5′ exon organization, a functional role for untranslated exon 1, and a broadly active promoter with eosinophil-selective elements

2000 • 34 citations

Effect of cetirizine, ketotifen and chlorpheniramine on the dynamics of the cutaneous hypersensitivity reaction: a comparative study

1992 • 31 citations

The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis

2004 • 29 citations

Nedocromil Sodium and Cromolyn (Sodium Cromoglycate) Selectively Inhibit Antibody-Dependent Granulocyte-Mediated Cytotoxicity

1988 • 28 citations

Uterine eosinophils and reproductive performance in interleukin 5-deficient mice

2000 • 26 citations

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

2002 • 22 citations

T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice

2004 • 22 citations

Eotaxin Is Required for Eosinophil Homing into the Stroma of the Pubertal and Cycling Uterus

2001 • 20 citations

Cytokines and allergy

1994 • 17 citations

Understanding exocytosis in immune and inflammatory cells: The molecular basis of mediator secretion

2003 • 13 citations

Pregnancy-associated major basic protein: Deposition of protein and expression of mRNA at the maternal-fetal junction in early and late gestation

1994 • 11 citations

Effect of intravenous administration of an anti-IL-5 mAb (Mepolizumab) on allergen-induced tissue eosinophilia, the late-phase allergic reaction and the expression of a marker of repair/remodeling in human atopic subjects

2003 • 9 citations