Eosinophils: structure and functions

Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils.

1992 • 683 citations

RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes.

1992 • 620 citations

Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics.

1992 • 364 citations

RANTES is a chemotactic and activating factor for human eosinophils.

1993 • 355 citations

The Biology of the Eosinophilic Leukocyte

1993 • 345 citations

Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils.

1991 • 344 citations

Increases in Activated T Lymphocytes, Eosinophils, and Cytokine mRNA Expression for Interleukin-5 and Granulocyte/Macrophage Colony-stimulating Factor in Bronchial Biopsies after Allergen Inhalation Challenge in Atopic Asthmatics

1993 • 336 citations

Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor.

1993 • 332 citations

Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells.

1993 • 313 citations

Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5.

1992 • 296 citations

Mechanisms of Eosinophil Recruitment

1993 • 274 citations

Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse.

1990 • 263 citations

Effect of Anti-IL-5 and IL-5 on Airway Hyperreactivity and Eosinophils in Guinea Pigs

1993 • 245 citations

Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease.

1992 • 244 citations

Human eosinophils express transforming growth factor alpha.

1990 • 237 citations

Adhesion to fibronectin prolongs eosinophil survival.

1993 • 226 citations

Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor beta 1 gene (TGF beta 1).

1992 • 224 citations

Expression of mRNA and immunoreactivity for the granulocyte/macrophage colony-stimulating factor in activated human eosinophils.

1991 • 209 citations

Comparison of airway and blood eosinophil function after in vivo antigen challenge.

1992 • 206 citations

Leukocyte chemotactic activity of cyclophilin.

1992 • 203 citations

IL-5 Is the Predominant Eosinophil-active Cytokine in the Antigen-induced Pulmonary Late-phase Reaction

1993 • 194 citations

Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1 beta-induced transendothelial migration.

1992 • 194 citations

Human eosinophils can express the cytokines tumor necrosis factor-alpha and macrophage inflammatory protein-1 alpha.

1993 • 188 citations

Eosinophil granule proteins in peripheral blood granulocytes

1992 • 183 citations

Accessory cell function of human eosinophils. HLA-DR-dependent, MHC-restricted antigen-presentation and IL-1 alpha expression.

1993 • 178 citations

A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo.

1993 • 177 citations

Eosinophils from patients with blood eosinophilia express transforming growth factor beta 1

1991 • 168 citations

Human eosinophils synthesize and secrete interleukin-6, in vitro

1992 • 152 citations

Depletion of eosinophils by anti-IL-5 monoclonal antibody treatment of mice infected with Trichinella spiralis does not alter parasite burden or immunologic resistance to reinfection.

1992 • 147 citations

Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration.

1993 • 137 citations

Human peripheral blood eosinophils produce and release interleukin‐8 on stimulation with calcium ionophore

1993 • 136 citations

In vivo priming of platelet-activating factor-induced eosinophil chemotaxis in allergic asthmatic individuals

1992 • 131 citations

The role of interleukin-5 in protective immunity to Strongyloides venezuelensis infection in mice.

1991 • 126 citations

Upregulation of formyl-peptide and interleukin-8—induced eosinophil chemotaxis in patients with allergic asthma

1993 • 125 citations

Eosinophil as antigen-presenting cell: activation of T cell clones and T cell hybridoma by eosinophils after antigen processing

1992 • 120 citations

92-kd gelatinase is actively expressed by eosinophils and stored by neutrophils in squamous cell carcinoma.

1993 • 110 citations

Induction and function of eosinophil intercellular adhesion molecule-1 and HLA-DR.

1992 • 106 citations

Cellular localization of tumor necrosis factor (TNF)-alpha transcripts in normal bowel and in necrotizing enterocolitis. TNF gene expression by Paneth cells, intestinal eosinophils, and macrophages.

1993 • 106 citations

Granulocyte/Macrophage Colony-stimulating Factor (GM-CSF) Gene Expression by Eosinophils in Nasal Polyposis

1991 • 105 citations

Modulation of Eosinophil Chemotaxis by Interleukin-5

1992 • 103 citations

Increased expression of CD11b and functional changes in eosinophils after migration across endothelial cell monolayers.

1993 • 102 citations

Induction of Intercellular Adhesion Molecule 1 (ICAM-1) Expression in Normal Human Eosinophils by Inflammatory Cytokines

1993 • 82 citations

Sequential expression of transforming growth factors alpha and beta 1 by eosinophils during cutaneous wound healing in the hamster.

1993 • 80 citations

Interaction of eosinophil granule major basic protein with synthetic lipid bilayers: A mechanism for toxicity

1992 • 79 citations

Ultrastructural immunogold localization of tumor necrosis factor-alpha to the matrix compartment of eosinophil secondary granules in patients with idiopathic hypereosinophilic syndrome.

1993 • 77 citations

Eosinophils are the major source of transforming growth factor-beta 1 in nodular sclerosing Hodgkin's disease.

1993 • 77 citations

Interleukin-6 expression in human neutrophil and eosinophil peripheral blood granulocytes

1993 • 77 citations

Factors Associated with Bronchial Responsiveness to Histamine in a Population Sample of Adults

1993 • 68 citations

Murine eosinophils and IL-1: alpha IL-1 mRNA detection by in situ hybridization. Production and release of IL-1 from peritoneal eosinophils.

1990 • 67 citations

Cytokine priming of the respiratory burst in human eosinophils is Ca2+ independent and accompanied by induction of tyrosine kinase activity

1993 • 59 citations

Neutrophil-specific granule deficiency includes eosinophils

1993 • 58 citations

Eosinophil Migration in Atopic Dermatitis I: Increased Migratory Responses to N-Formyl-Methionyl-Leucyl-Phenylalanine, Neutrophil-Activating Factor, Platelet-Activating Factor, and Platelet Factor 4

1993 • 55 citations

Human platelets secrete chemotactic activity for eosinophils

1993 • 50 citations

Type beta transforming growth factors promote interleukin-3 (IL-3)- dependent differentiation of human basophils but inhibit IL-3-dependent differentiation of human eosinophils

1992 • 49 citations

Immunoglobulin E-mediated Increase in Vascular Permeability Correlates with Eosinophilic Inflammation

1993 • 47 citations

Eosinophil peroxidase deficiency: morphological and immunocytochemical studies of the eosinophil-specific granules

1992 • 30 citations

Increased protein kinase C activity in low density eosinophils.

1993 • 26 citations

Platelet-activating Factor-induced Human Eosinophil Transendothelial Migration: Evidence for a Dynamic Role of the Endothelium

1993 • 20 citations