Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

The Basic Science of Gene Therapy

1993 • 1,767 citations

The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

1994 • 1,109 citations

Human gene therapy comes of age

1992 • 927 citations

In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells

1999 • 832 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation

1995 • 496 citations

Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes.

1991 • 489 citations

Identification of a lineage of multipotent hematopoietic progenitors

1997 • 466 citations

Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients

1993 • 434 citations

Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment.

1997 • 431 citations

Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.

1994 • 415 citations

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

1995 • 357 citations

T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates

1998 • 334 citations

De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells.

1982 • 299 citations

Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells

1993 • 296 citations

A Clinical Trial of Retroviral-Mediated Transfer of arev-Responsive Element Decoy Gene Into CD34+Cells From the Bone Marrow of Human Immunodeficiency Virus-1–Infected Children

1999 • 257 citations

Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase

1997 • 250 citations

Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites

1987 • 248 citations

The Fluctuating Phenotype of the Lymphohematopoietic Stem Cell with Cell Cycle Transit

1998 • 229 citations

Acceptor sites for retroviral integrations map near DNase I-hypersensitive sites in chromatin

1986 • 212 citations

Transcriptionally active genome regions are preferred targets for retrovirus integration

1990 • 210 citations

Efficient transfer and sustained high expression of the human glucocerebrosidase gene in mice and their functional macrophages following transplantation of bone marrow transduced by a retroviral vector.

1992 • 183 citations

Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position

1991 • 161 citations

A majority of mice show long-term expression of a human beta-globin gene after retrovirus transfer into hematopoietic stem cells.

1989 • 153 citations

Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells

1998 • 143 citations

Increased probability of expression from modified retroviral vectors in embryonal stem cells and embryonal carcinoma cells

1997 • 123 citations

Gene therapy for hemophilia A: production of therapeutic levels of human factor VIII in vivo in mice.

1995 • 113 citations

Retroviral integration sites in transgenic Mov mice frequently map in the vicinity of transcribed DNA regions

1990 • 113 citations

Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells

1998 • 110 citations

Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer

1994 • 108 citations

Sustained Gene Expression in Retrovirally Transduced, Engrafting Human Hematopoietic Stem Cells and Their Lympho-Myeloid Progeny

1998 • 88 citations

Sustained High-Level Reconstitution of the Hematopoietic System by Preselected Hematopoietic Cells Expressing a Transduced Cell-Surface Antigen

1997 • 80 citations

High transdominant RevM10 protein levels are required to inhibit HIV-1 replication in cell lines and primary T cells: implication for gene therapy of AIDS

1997 • 78 citations

High levels of human glucocerebrosidase activity in macrophages of long- term reconstituted mice after retroviral infection of hematopoietic stem cells

1992 • 62 citations

T Cell Activation Modulates Retrovirus-Mediated Gene Expression

1998 • 52 citations

Retroviral Stem Cell Gene Therapy

1997 • 48 citations

Factors affecting the transduction of pluripotent hematopoietic stem cells: long-term expression of a human adenosine deaminase gene in mice

1993 • 31 citations

High-frequency cell surface expression of a foreign protein in murine hematopoietic stem cells using a new retroviral vector

1996 • 29 citations