Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer.

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

Cyclosporine

1989 • 1,340 citations

Affinity purification of sequence-specific DNA binding proteins.

1986 • 1,255 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

1990 • 993 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

High efficiency polyoma DNA transfection of chloroquine treated cells

1983 • 711 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

1984 • 623 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

Induction of Interleukin 2 Messenger RNA Inhibited by Cyclosporin A

1984 • 404 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

Regulation of human interleukin-2 gene: Functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes

1986 • 288 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes.

1985 • 257 citations

Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.

1989 • 256 citations

A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.

1987 • 174 citations

Complexity of the primary genetic response to mitogenic activation of human T cells.

1989 • 149 citations

Characterization of Antigen Receptor Response Elements within the Interleukin-2 Enhancer

1988 • 143 citations

Structure of the chromosomal gene for murine interleukin 3.

1985 • 129 citations

A purine-rich DNA sequence motif present in SV40 and lymphotropic papovavirus binds a lymphoid-specific factor and contributes to enhancer activity in lymphoid cells.

1987 • 110 citations

lnterleukin-2-dependent autocrine proliferation in T-cell development

1989 • 107 citations

Transcription factors AP-3 and AP-2 interact with the SV40 enhancer in a mutually exclusive manner.

1989 • 90 citations

Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities

1987 • 89 citations

A viral enhancer element specifically active in human haematopoietic cells

1985 • 84 citations

Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes

1989 • 60 citations

Nuclear factors interacting with the mitogen-responsive regulatory region of the interleukin-2 gene.

1988 • 53 citations

Complexity of the Primary Genetic Response to Mitogenic Activation of Human T Cells

1989 • 50 citations

Identification of multiplecis-elements andtrans-acting factors involved in the induced expresson of human IL-2 gene

1989 • 39 citations

Cyclosporine--mechanism of action.

1988 • 25 citations

A COMPARISON OF CYCLOSPORINE BINDING BY CYCLOPHILIN AND CALMODULIN AND THE IDENTIFICATION OF A NOVEL 45 KD CYCLOSPORINE-BINDING PHOSPHOPROTEIN IN JURKAT CELLS

1988 • 23 citations

Hie 5′ region of the human interleukin 4 gene: structure and potential regulatory elements

1988 • 12 citations