Physical and Functional Interaction between Wild-Type p53 and mdm2 Proteins

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

p53 function and dysfunction

1992 • 1,918 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1987 • 357 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Inhibition of viral and cellular promoters by human wild-type p53

1992 • 178 citations

Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex

1986 • 175 citations

Involvement of wild-type p53 in pre-B-cell differentiation in vitro.

1991 • 168 citations

Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest.

1992 • 123 citations