von Willebrand factor.

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Synthesis of Antihemophilic Factor Antigen by Cultured Human Endothelial Cells

1973 • 1,303 citations

Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells

1982 • 698 citations

Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif

1991 • 580 citations

Structure of the gene for human von Willebrand factor

1989 • 497 citations

Amino acid sequence of human von Willebrand factor

1986 • 486 citations

Inducible secretion of large, biologically potent von Willebrand factor multimers

1986 • 459 citations

An Abnormal Platelet Glycoprotein Pattern in Three Cases of Glanzmann's Thrombasthenia

1974 • 445 citations

Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization

1985 • 420 citations

Platelet Membrane Defects in Glanzmann's Thrombasthenia

1977 • 391 citations

Synthesis of Factor VIII Antigen by Cultured Guinea Pig Megakaryocytes

1977 • 390 citations

Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor.

1990 • 347 citations

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

1985 • 302 citations

Immunochemistry, genuine size and tissue localization of collagen VI

1984 • 294 citations

Induction of specific storage organelles by von Willebrand factor propolypeptide

1991 • 276 citations

A major factor VIII binding domain resides within the amino-terminal 272 amino acid residues of von Willebrand factor.

1987 • 263 citations

Identification of disulfide-bridged substructures within human von Willebrand factor

1987 • 262 citations

The role of platelet membrane glycoproteins Ib and IIb-IIIa in platelet adherence to human artery subendothelium

1986 • 237 citations

Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction

1991 • 235 citations

New variant of von Willebrand disease with defective binding to factor VIII

1989 • 234 citations

v. Willebrand's Disease and its Correction with Human Plasma Fraction 1‐0

1957 • 215 citations

Structure of the von Willebrand factor domain interacting with glycoprotein Ib.

1988 • 208 citations

The superfamily of proteins with von Willebrand factor type A-like domains: one theme common to components of extracellular matrix, hemostasis, cellular adhesion, and defense mechanisms

1991 • 206 citations

The propeptide of von Willebrand Factor independently mediates the assembly of von Willebrand multimers

1988 • 192 citations

Thrombin-induced exposure and prostacyclin inhibition of the receptor for factor VIII/von Willebrand factor on human platelets.

1982 • 190 citations

Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand's disease

1982 • 180 citations

Composition of the von Willebrand factor storage organelle (Weibel-Palade body) isolated from cultured human umbilical vein endothelial cells.

1987 • 176 citations

Gene deletions correlate with the development of alloantibodies in von Willebrand disease.

1987 • 170 citations

Venom coagglutinin: an activator of platelet aggregation dependent on von Willebrand factor.

1978 • 158 citations

Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene

1985 • 157 citations

A heparin-binding domain of human von Willebrand factor. Characterization and localization to a tryptic fragment extending from amino acid residue Val-449 to Lys-728.

1987 • 156 citations

A new von Willebrand factor (vWF) defect in a patient with factor VIII (FVIII) deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF. Characterization of abnormal vWF/FVIII interaction

1990 • 152 citations

Eccentric localization of von Willebrand factor in an internal structure of platelet alpha-granule resembling that of Weibel-Palade bodies

1985 • 150 citations

Isolation of the von Willebrand Factor Domain Interacting with Platelet Glycoprotein Ib, Heparin, and Collagen and Characterization of Its Three Distinct Functional Sites

1989 • 147 citations

Localization of binding sites within human von Willebrand factor for monomeric type III collagen

1986 • 145 citations

Dimeric ristocetin flocculates proteins, binds to platelets, and mediates von Willebrand factor-dependent agglutination of platelets

1991 • 137 citations

Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib.

1991 • 135 citations

Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA.

1989 • 135 citations

Domains involved in multimer assembly of von willebrand factor (vWF): multimerization is independent of dimerization.

1990 • 134 citations

Expression of variant von Willebrand factor (vWF) cDNA in heterologous cells: requirement of the pro-polypeptide in vWF multimer formation.

1987 • 127 citations

Cross-linking of a monomeric 39/34-kDa dispase fragment of von Willebrand factor (Leu-480/Val-481-Gly-718) to the N-terminal region of the .alpha.-chain of membrane glycoprotein Ib on intact platelets with bis(sulfosuccinimidyl) suberate

1989 • 122 citations

The molecular defect in type IIB von Willebrand disease. Identification of four potential missense mutations within the putative GpIb binding domain.

1991 • 120 citations

von Willebrand's disease antigen II. A new plasma and platelet antigen deficient in severe von Willebrand's disease.

1978 • 120 citations

Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequences.

1991 • 117 citations

In vitro Multimerization of von Willebrand Factor Is Triggered by Low pH

1989 • 116 citations

150-kD von Willebrand factor binding protein extracted from human vascular subendothelium is type VI collagen.

1991 • 109 citations

Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells.

1987 • 105 citations

Homozygous and heterozygous deletions of the von Willebrand factor gene in patients and carriers of severe von Willebrand disease.

1988 • 102 citations

Von Willebrand protein binds to extracellular matrices independently of collagen.

1984 • 98 citations

Substructure of human von Willebrand factor. Proteolysis by V8 and characterization of two functional domains.

1986 • 94 citations

von Willebrand factor binds specifically to sulfated glycolipids.

1986 • 94 citations

Generation and characterization of peptide-specific antibodies that inhibit von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro1743 and other amino acid residues adjacent to the sequence Arg1744-Gly1745-Asp1746.

1988 • 90 citations

Multimeric analysis of von Willebrand factor by molecular sieving electrophoresis in sodium dodecyl sulphate agarose gel

1990 • 89 citations

Type VI collagen represents a major fraction of connective tissue collagens

1987 • 87 citations

Expression of von Willebrand factor "Normandy": an autosomal mutation that mimics hemophilia A.

1991 • 86 citations

Abnormal binding of factor VIII is linked with the substitution of glutamine for arginine 91 in von Willebrand factor in a variant form of von Willebrand disease.

1991 • 80 citations

Immunoinhibition of ristocetin-induced platelet aggregation.

1977 • 77 citations

The Effects of Ristocetin and von Willebrand Factor on Platelet Electrophoretic Mobility

1978 • 75 citations

Evidence that the primary binding site of von Willebrand factor that mediates platelet adhesion on subendothelium is not collagen.

1988 • 72 citations

Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor.

1991 • 72 citations

Severe type III von Willebrand's disease caused by deletion of exon 42 of the von Willebrand factor gene: family studies that identify carriers of the condition and a compound heterozygous individual

1990 • 71 citations

The "Normandy" variant of von Willebrand disease: characterization of a point mutation in the von Willebrand factor gene

1991 • 70 citations

An integumentary mucin (FIM-B.1) from Xenopus laevis homologous with the von Willebrand factor

1990 • 69 citations

Adsorption of von Willebrand factor/factor VIII by the genetically distinct interstitial collagens

1981 • 68 citations

von Willebrand Factor Biosynthesis and Processinga

1991 • 67 citations

Molecular characterization of a unique von Willebrand disease variant. A novel mutation affecting von Willebrand factor/factor VIII interaction

1991 • 66 citations

The carboxyl terminus of the chicken α3 chain of collagen VI is a unique mosaic structure with glycoprotein Ib-like, fibronectin type III, and Kunitz modules

1989 • 62 citations

von Willebrand Factor and Platelet Functiona

1991 • 60 citations

Identification of two point mutations in the von Willebrand factor gene of three families with the ‘Normandy’variant of von Willebrand disease

1991 • 60 citations

The von willebrand factor domain-mediating botrocetin-induced binding to glycoprotein IB lies between Val449 and Lys728

1987 • 58 citations

Von Willebrand factor shares a distinctive cysteine-rich domain with thrombospondin and procollagen

1987 • 57 citations

Biosynthesis of chick type VI collagen. II. Processing and secretion in fibroblasts and smooth muscle cells.

1987 • 52 citations

Molecular cloning of the human gene for von Willebrand factor and identification of the transcription initiation site.

1987 • 50 citations

The human von Willebrand factor gene

1988 • 41 citations

Sulfation of von Willebrand factor

1990 • 39 citations

Duplication of a methionine within the glycoprotein Ib binding domain of von Willebrand factor detected by denaturing gradient gel electrophoresis in a patient with type IIB von Willebrand disease

1991 • 38 citations

Collagen-binding domain within bovine propolypeptide of von Willebrand factor.

1991 • 30 citations

The human gene for von willebrand factor. Identification of repetitive ALU sequences 5′ to the transcription initiation site

1988 • 24 citations