Identifying off-target effects and hidden phenotypes of drugs in human cells

The Hallmarks of Cancer

2000 • 27,569 citations

Hierarchical Grouping to Optimize an Objective Function

1963 • 17,257 citations

A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

2002 • 2,692 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

Visualization of Interactions among bZIP and Rel Family Proteins in Living Cells Using Bimolecular Fluorescence Complementation

2002 • 1,516 citations

The specificities of protein kinase inhibitors: an update

2003 • 1,345 citations

J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

1991 • 1,017 citations

Atypical Membrane Topology and Heteromeric Function of Drosophila Odorant Receptors In Vivo

2006 • 951 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

1999 • 784 citations

Integrated Genomic and Proteomic Analyses of Gene Expression in Mammalian Cells

2004 • 753 citations

Antiparallel Leucine Zipper-Directed Protein Reassembly: Application to the Green Fluorescent Protein

2000 • 516 citations

Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization

1996 • 450 citations

β-Lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein–protein interactions

2002 • 403 citations

PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3

2004 • 369 citations

Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments

1998 • 366 citations

Post-prenylation-processing enzymes as new targets in oncogenesis

2005 • 338 citations

Cyclin Ubiquitination: The destructive end of mitosis

1995 • 304 citations

Geldanamycin as a Potential Anti-Cancer Agent: Its Molecular Target and Biochemical Activity

1999 • 297 citations

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

2005 • 285 citations

Mechanism of Action of Reagents that uncouple Oxidative Phosphorylation

1969 • 258 citations

Translationally controlled tumor protein is a target of tumor reversion

2004 • 232 citations

A potent PPARα agonist stimulates mitochondrial fatty acid β-oxidation in liver and skeletal muscle

2001 • 183 citations

Capturing protein interactions in the secretory pathway of living cells

2005 • 181 citations

Microarray reality checks in the context of a complex disease

2004 • 175 citations

Clotrimazole inhibits cell proliferation in vitro and in vivo

1995 • 162 citations

Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism

1997 • 158 citations

Direct visualization of protein interactions in plant cells

2001 • 147 citations

[14] Detection of protein-protein interactions by protein fragment complementation strategies

2000 • 135 citations

Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes

2004 • 129 citations

Regulation of Apoptosis by the Ft1 Protein, a New Modulator of Protein Kinase B/Akt

2004 • 122 citations

How molecular profiling could revolutionize drug discovery

2005 • 121 citations

Pub1 acts as an E6-AP-like protein ubiquitiin ligase in the degradation of cdc25.

1996 • 110 citations

Visualization of biochemical networks in living cells

2001 • 102 citations

Phosphorylation of β-Arrestin2 Regulates Its Function in Internalization of β₂-Adrenergic Receptors

2002 • 93 citations

A cDNA library functional screening strategy based on fluorescent protein complementation assays to identify novel components of signaling pathways

2004 • 89 citations

Patulin-induced cellular toxicity: A vital fluorescence study

1992 • 79 citations

Reporting the assessment of screening and diagnostic tests

1989 • 79 citations

The effect of peroxisome proliferators on mitochondrial bioenergetics

1999 • 72 citations

Measuring Drug Action in the Cellular Context Using Protein-Fragment Complementation Assays

2003 • 47 citations

The effects of the Penicillium mycotoxins citrinin, cyclopiazonic acid, ochratoxin A, patulin, penicillic acid, and roquefortine C on in vitro proliferation of porcine lymphocytes

2004 • 46 citations

Detection of TAP Family Dimerizations by anin VivoAssay in Mammalian Cells

2004 • 27 citations