Multiple Sclerosis

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

2001 • 6,888 citations

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Defining the clinical course of multiple sclerosis

1996 • 3,606 citations

Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

2000 • 3,258 citations

Intramuscular interferon beta‐1a for disease progression in relapsing multiple sclerosis

1996 • 2,410 citations

Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis

1998 • 2,049 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 2,032 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 1,908 citations

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

The clinical course of neuromyelitis optica (Devic’s syndrome)

1999 • 1,772 citations

Axonal damage in acute multiple sclerosis lesions

1997 • 1,543 citations

Intramuscular Interferon Beta-1A Therapy Initiated during a First Demyelinating Event in Multiple Sclerosis

2000 • 1,497 citations

Relapses and Progression of Disability in Multiple Sclerosis

2000 • 1,285 citations

A Randomized, Controlled Trial of Corticosteroids in the Treatment of Acute Optic Neuritis

1992 • 1,254 citations

Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis

1997 • 1,246 citations

TNF neutralization in MS

1999 • 968 citations

Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis

1998 • 931 citations

Identification of autoantibodies associated with myelin damage in multiple sclerosis

1999 • 881 citations

A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease

1999 • 878 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

A full genome search in multiple sclerosis

1996 • 666 citations

Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis

1998 • 652 citations

A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

1996 • 638 citations

A genetic basis for familial aggregation in multiple sclerosis

1995 • 626 citations

Spinal cord atrophy and disability in multiple sclerosis

1996 • 618 citations

Plaque-associated expression of human herpesvirus 6 in multiple sclerosis.

1995 • 611 citations

Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions

1993 • 556 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

Molecular Mimicry and Autoimmunity

1999 • 523 citations

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

2000 • 506 citations

Primary progressive multiple sclerosis

1997 • 505 citations

The prognostic value of brain MRI in clinically isolated syndromes of the CNS. A 10-year follow-up

1998 • 483 citations

Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA

1997 • 446 citations

Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis

1996 • 444 citations

THE NATURAL HISTORY OF MULTIPLE SCLEROSIS: A GEOGRAPHICALLY BASED STUDY

1991 • 409 citations

Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis

1997 • 386 citations

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

1996 • 362 citations

Evidence for genetic basis of multiple sclerosis

1996 • 355 citations

Criteria for an increased specificity of MRI interpretation in elderly subjects with suspected multiple sclerosis

1988 • 352 citations

Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study

1999 • 345 citations

Interferon beta in the treatment of multiple sclerosis

1998 • 340 citations

A longitudinal study of brain atrophy in relapsing multiple sclerosis

1999 • 334 citations

Magnetic resonance studies of intramuscular interferon β–1a for relapsing multiple sclerosis

1998 • 334 citations

Revised estimate of the prevalence of multiple sclerosis in the united states

1992 • 317 citations

The Natural History of Multiple Sclerosis

1995 • 315 citations

Association between clinical disease activity and Epstein–Barr virus reactivation in MS

2000 • 290 citations

Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: A case for antigen-specific antibody mediation

1999 • 289 citations

The contribution of magnetic resonance imaging to the diagnosis of multiple sclerosis

1999 • 286 citations

Progress in determining the causes and treatment of multiple sclerosis

1999 • 280 citations

Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis

2000 • 255 citations

The role of B cells and autoantibodies in multiple sclerosis

2000 • 254 citations

Mechanisms of action of glatiramer acetate in multiple sclerosis

2001 • 252 citations

Immunoglobulins promote remyelination in the central nervous system

1990 • 211 citations

Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis

1998 • 198 citations

A point mutation in PTPRC is associated with the development of multiple sclerosis

2000 • 194 citations

Open-ring imaging sign

2000 • 193 citations

Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years

2000 • 191 citations

The natural history of multiple sclerosis: a geographically based study

1999 • 181 citations

APOE genotype is a major predictor of long-term progression of disability in MS

2001 • 176 citations

Impairment, disability, and handicap in multiple sclerosis

1994 • 176 citations

Effect of interferon-?1b on magnetic resonance imaging outcomes in secondary progressive multiple sclerosis: Results of a European multicenter, randomized, double-blind, placebo-controlled trial

1999 • 158 citations

Oligoclonal banding of IgG in CSF, blood-brain barrier function, and MRI findings in patients with sarcoidosis, systemic lupus erythematosus, and Behcet's disease involving the nervous system.

1995 • 157 citations

Multiple sclerosis: Genomic rewards

2001 • 140 citations

Practice parameter: The usefulness of evoked potentials in identifying clinically silent lesions in patients with suspected multiple sclerosis (an evidence-based review)

2000 • 130 citations

Multiple sclerosis in Australia and New Zealand: are the determinants genetic or environmental?

1990 • 111 citations

Multiple Sclerosis: Lessons from Neuropathology

1998 • 107 citations

IV immunoglobulin does not reverse established weakness in MS

2000 • 107 citations

Two models of multiple sclerosis: Experimental allergic encephalomyelitis (EAE) and theiler's murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison

1995 • 104 citations

Failure to detect Chlamydia pneumoniae in the central nervous system of patients with MS

2000 • 102 citations

Occurrence of multiple sclerosis in the north and south of New Zealand.

1987 • 88 citations

Glutathione S-transferase polymorphisms in MS

2000 • 87 citations

The Open Ring A New Imaging Sign in Demyelinating Disease

1996 • 86 citations

An open‐trial evaluation of mitoxantrone in the treatment of progressive MS

1993 • 86 citations

Magnetic resonance spectroscopy: imaging axonal damage in MS

1999 • 76 citations

A phase I trial of solubilized DR2:MBP ^84-102 (AG284) in multiple sclerosis

2000 • 65 citations

Infrequent detection of human herpesvirus 6 DNA in peripheral blood mononuclear cells from multiple sclerosis patients

1998 • 57 citations

HLA‐DP‐associated susceptibility to the optico‐spinal form of multiple sclerosis in the Japanese

1998 • 54 citations

Viruses and multiple sclerosis

1997 • 52 citations

Multiple Sclerosis: Symptomatic Therapies

1998 • 32 citations

Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis

1999 • 31 citations

Adoptively transferred experimental autoimmune encephalomyelitis in SJL/J, PL/J, and (SJL/J x PL/J)F1 mice. Influence of I-A haplotype on encephalitogenic epitope of myelin basic protein.

1988 • 26 citations

ACUTE LEUKOENCEPHALOPATHIES

1998 • 22 citations

Hopeful genes and immunology

1989 • 18 citations

European/Canadian multicenter, double‐blind, randomized, placebo‐controlled study of the effects of glatiramer acetate on magnetic resonance imaging–measured disease activity and burden in patients with relapsing multiple sclerosis

2001 • 14 citations