Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

1997 • 1,647 citations

Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production

1980 • 1,430 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

1995 • 1,026 citations

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

1994 • 813 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Leptin Receptors Expressed on Pancreatic β-Cells

1996 • 332 citations

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

1996 • 321 citations

Pancreatic β-Cells in Obesity

1995 • 276 citations

Obese Gene Expression Alters the Ability of 30A5 Preadipocytes to Respond to Lipogenic Hormones

1996 • 238 citations

Substitution at Codon 269 (Glutamine → Proline) of the Leptin Receptor (OB-R) cDNA Is the Only Mutation Found in the Zucker Fatty (fa/fa) Rat

1996 • 186 citations

Increased Lipogenic Capacity of the Islets of Obese Rats: A Role in the Pathogenesis of NIDDM

1997 • 180 citations

More Direct Evidence for a Malonyl-CoA–Carnitine Palmitoyltransferase I Interaction as a Key Event in Pancreatic β-Cell Signaling

1994 • 172 citations

β-Cell Function in Normal Rats Made Chronically Hyperleptinemic by Adenovirus-Leptin Gene Therapy

1997 • 134 citations

Defective Fatty Acid-mediated β-Cell Compensation in Zucker Diabetic Fatty Rats

1996 • 126 citations

Preliminary characterization of calcium binding in islet-cell plasma membranes

1980 • 73 citations