Direct effects of leptin on brown and white adipose tissue.

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

Positional cloning of the mouse obese gene and its human homologue

1995 • 1,164 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Leptin: The Tale of an Obesity Gene

1996 • 987 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells

1996 • 751 citations

Role of leptin in hypothalamic–pituitary function

1997 • 744 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Expression of the Functional Leptin Receptor mRNA in Pancreatic Islets and Direct Inhibitory Action of Leptin on Insulin Secretion

1997 • 511 citations

A role for leptin and its cognate receptor in hematopoiesis

1996 • 478 citations

Leptin Impairs Metabolic Actions of Insulin in Isolated Rat Adipocytes

1997 • 463 citations

Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase

1996 • 404 citations

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation

1997 • 384 citations

A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat

1985 • 337 citations

Leptin Receptors Expressed on Pancreatic β-Cells

1996 • 332 citations

Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein.

1984 • 329 citations

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

1996 • 321 citations

Direct Intraovarian Effects of Leptin: Impairment of the Synergistic Action of Insulin-Like Growth Factor-I on Follicle-Stimulating Hormone-Dependent Estradiol-17β Production by Rat Ovarian Granulosa Cells*

1997 • 307 citations

Leptin Receptor (OB-R) Signaling

1997 • 290 citations

Phenotype of fatty Due to Gln269Pro Mutation in the Leptin Receptor (Lepr)

1996 • 289 citations

Obese Gene Expression Alters the Ability of 30A5 Preadipocytes to Respond to Lipogenic Hormones

1996 • 238 citations

The peroxisome proliferator activated receptor regulates malic enzyme gene expression.

1994 • 157 citations

In vivo glucose metabolism in individual tissues of the rat. Interaction between epinephrine and insulin.

1986 • 134 citations

Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion

1997 • 134 citations

Interleukin-6 Enhances Glucose Transport in 3T3-L1 Adipocytes

1996 • 118 citations

Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells.

1996 • 116 citations

Severe Hepatic and Peripheral Insulin Resistance as Evidenced by Euglycemic Clamps in Genetically Obesefa/faRats*

1986 • 99 citations

Direct Intraovarian Effects of Leptin: Impairment of the Synergistic Action of Insulin-Like Growth Factor-I on Follicle-Stimulating Hormone-Dependent Estradiol-17 Production by Rat Ovarian Granulosa Cells

1997 • 91 citations

Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr)

1996 • 79 citations

Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: Effects of hypothyroidism and norepinephrine

1989 • 78 citations

The Thiazolidinedione Insulin Sensitiser, BRL 49653, Increases the Expression of PPAR-γ and aP2in Adipose Tissue of High-Fat-Fed Rats

1996 • 76 citations

Coding nucleotide sequence of rat liver malic enzyme mRNA.

1986 • 63 citations

Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells

1996 • 46 citations

Thyromimetic mode of action of peroxisome proliferators: activation of ‘malic’ enzyme gene transcription

1996 • 32 citations

Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization.

1997 • 29 citations

Increased sensitivity of diabetic rat adipose tissue towards the lipolytic action of epinephrine

1975 • 23 citations

Normal differentiation of rat brown adipocytes in primary culture judged by their expressions of uncoupling protein and the physiological isoform of glucose transporter

1994 • 18 citations