The presence of intervening sequences in the alpha-fetoprotein gene of the mouse.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis

1969 • 20,498 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. 1977.

1992 • 4,683 citations

A membrane-filter technique for the detection of complementary DNA

1966 • 3,996 citations

Construction and characterization of new cloning vehicle. II. A multipurpose cloning system

1977 • 3,829 citations

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

1975 • 3,483 citations

Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

1977 • 2,408 citations

Nucleotide sequence of the rightward operator of phage lambda.

1975 • 2,068 citations

The isolation of structural genes from libraries of eucaryotic DNA

1978 • 1,877 citations

Spliced segments at the 5′ terminus of adenovirus 2 late mRNA

1977 • 1,301 citations

ANTIGEN‐ANTIBODY REACTIONS IN GELS

1953 • 1,271 citations

Rat Insulin Genes: Construction of Plasmids Containing the Coding Sequences

1977 • 1,252 citations

Efficient Translation of Tobacco Mosaic Virus RNA and Rabbit Globin 9S RNA in a Cell-Free System from Commercial Wheat Germ

1973 • 1,213 citations

An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA

1977 • 1,138 citations

Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis

1975 • 1,135 citations

Alpha-Fetoprotein in Ontogenesis and its Association with Malignant Tumors

1971 • 892 citations

ALPHA-FETOPROTEIN IN THE ANTENATAL DIAGNOSIS OF ANENCEPHALY AND SPINA BIFIDA

1972 • 603 citations

PRODUCTION OF EMBRYONAL α-GLOBULIN BY TRANSPLANTABLE MOUSE HEPATOMAS

1963 • 601 citations

Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation.

1977 • 543 citations

The rabbit β-globin gene contains a large insert in the coding sequence

1977 • 422 citations

Serum alpha-fetoprotein, albumin, and gamma-G-globulin in the human conceptus.

1966 • 417 citations

Onco-developmental gene expression

1976 • 401 citations

Ovalbumin gene is split in chicken DNA

1977 • 396 citations

Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I.

1978 • 395 citations

Protein expression in E. coli minicells by recombinant plasmids

1977 • 356 citations

The structural organization of ribosomal DNA in drosophila melanogaster

1977 • 342 citations

Nucleotide sequence of a mutant eukaryotic gene: the yeast tyrosine-inserting ochre suppressor SUP4-o.

1977 • 339 citations

Transcription and processing of intervening sequences in yeast tRNA genes

1978 • 332 citations

Embryonal serum α‐globulin in cancer patients: Diagnostic value

1967 • 307 citations

R loop mapping of the 18S and 28S sequences in the long and short repeating units of drosophila melanogaster rDNA

1977 • 305 citations

Intragenic DNA spacers interrupt the ovalbumin gene

1978 • 284 citations

Two adenovirus mRNAs have a common 5′ terminal leader sequence encoded at least 10 kb upstream from their main coding regions

1977 • 283 citations

Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene.

1978 • 254 citations

The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor.

1978 • 242 citations

Structure of yeast phenylalanine-tRNA genes: an intervening DNA segment within the region coding for the tRNA.

1978 • 231 citations

Occurrence of fetoprotein in patients with neoplasms and non‐neoplastic diseases

1968 • 219 citations

Sequence arrangement of the rDNA of Drosophila melanogaster

1977 • 214 citations

Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda

1977 • 205 citations

Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences.

1977 • 169 citations

Structure and processing of yeast precursor tRNAs containing intervening sequences

1978 • 149 citations

[68] The wheat embryo cell-free system

1974 • 142 citations

A comparison of two cloned mouse β-globin genes and their surrounding and intervening sequences

1978 • 142 citations

Synthesis of Rat Liver Albumin in a Rabbit Reticulocyte Cell-free Protein-synthesizing System

1973 • 137 citations

Genetic control of alpha-fetoprotein synthesis in the mouse.

1977 • 135 citations

Increase in level of functional messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) during induction by cyclic adenosine 3':5'-monophosphate.

1977 • 133 citations

Fetus-specific serum proteins in several mammals and their relation to human α-fetoprotein

1967 • 131 citations

High capacity gel preparative electrophoresis for purification of fragments of genomic DNA

1978 • 128 citations

Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA.

1977 • 126 citations

FETAL PATHOPHYSIOLOGY OF HUMAN ?-FETOPROTEIN

1975 • 91 citations

The presence of ovalbumin mRNA coding sequences in multiple restriction fragments of chicken DNA

1977 • 91 citations

Purification and chemical characterization of α‐fetoprotein from rat and mouse

1974 • 88 citations

Comparison of the nucleotide sequence of the messenger RNA for the major structural protein of SV40 with the DNA sequence encoding the amino acids of the protein.

1977 • 81 citations

Safer derivatives of bacteriophage λgt.λC for use in cloning of recombinant DNA molecules

1976 • 78 citations

The ovalbumin gene: structural sequences in native chicken DNA are not contiguous.

1978 • 49 citations

Quantitation of rat alpha-fetoprotein messenger RNA with a complementary DNA probe

1977 • 47 citations

Developmental microheterogeneity of mouse α-fetoproteins: purification and partial characterization

1976 • 39 citations

Yolk sac: Site of developmental microheterogeneity of mouse α-fetoprotein

1976 • 34 citations

Transcriptional control of α-foetoprotein synthesis in developing mouse liver

1974 • 20 citations