Probucol

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE

1975 • 2,653 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

Lipid peroxides and human diseases

1987 • 1,358 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Oxygen free radicals in ischemic acute renal failure in the rat.

1984 • 1,041 citations

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

1987 • 885 citations

Increased High-Density Lipoprotein Levels Caused by a Common Cholesteryl-Ester Transfer Protein Gene Mutation

1990 • 848 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Lipoprotein receptors and cholesterol homeostasis

1983 • 755 citations

Probucol inhibits oxidative modification of low density lipoprotein.

1986 • 633 citations

Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.

1987 • 625 citations

Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.

1983 • 623 citations

Role of oxidatively modified LDL in atherosclerosis

1990 • 614 citations

Characterization of human high-density lipoproteins by gradient gel electrophoresis

1981 • 610 citations

Relation of Serum Lipoprotein(a) Concentration and Apolipoprotein(a) Phenotype to Coronary Heart Disease in Patients with Familial Hypercholesterolemia

1990 • 591 citations

Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit) *1Incidence and development of atherosclerosis and xanthoma

1980 • 540 citations

Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism.

1987 • 473 citations

Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins

1989 • 468 citations

Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.

1989 • 467 citations

Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo.

1986 • 418 citations

Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications

1987 • 400 citations

Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.

1985 • 388 citations

Fatty streak initiation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbits.

1987 • 337 citations

Deletion in Cysteine-Rich Region of LDL Receptor Impedes Transport to Cell Surface in WHHL Rabbit

1986 • 335 citations

Lipid peroxide levels of serum lipoprotein fractions of diabetic patients

1981 • 305 citations

Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice

1991 • 300 citations

Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia.

1983 • 282 citations

The antioxidant hypothesis of cardiovascular disease: epidemiology and mechanisms

1990 • 276 citations

Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity.

1989 • 265 citations

Nonenzymatic oxidative cleavage of peptide bonds in apoprotein B-100.

1987 • 254 citations

Pathophysiology of reverse cholesterol transport. Insights from inherited disorders of lipoprotein metabolism.

1989 • 241 citations

Effects of probucol on xanthomata regression in familial hypercholesterolemia

1986 • 232 citations

Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification.

1991 • 228 citations

Plasma concentrations of cholesteryl ester transfer protein in hyperlipoproteinemia. Relation to cholesteryl ester transfer protein activity and other lipoprotein variables.

1991 • 217 citations

The bidirectional flux of cholesterol between cells and lipoproteins. Effects of phospholipid depletion of high density lipoprotein.

1986 • 186 citations

Fatty streak expansion and maturation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbits.

1987 • 174 citations

Recognition of solubilized apoproteins from delipidated, oxidized low density lipoprotein (LDL) by the acetyl-LDL receptor.

1987 • 171 citations

Probucol

1989 • 161 citations

Interaction of lipoprotein Lp(a) and low density lipoprotein with glycosaminoglycans from human aorta.

1988 • 158 citations

Lesion-derived low density lipoprotein and oxidized low density lipoprotein share a lability for aggregation, leading to enhanced macrophage degradation.

1991 • 158 citations

Free radical modification of low-density lipoprotein: Mechanisms and biological consequences

1987 • 150 citations

Probucol attenuates the development of aortic atherosclerosis in cholesterol‐fed rabbits

1989 • 142 citations

Ischemic acute renal failure and antioxidant therapy in the rat. The relation between glomerular and tubular dysfunction.

1988 • 140 citations

Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects

1983 • 138 citations

Oxidation of lipoprotein Lp(a). A comparison with low-density lipoproteins

1991 • 137 citations

Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia.

1982 • 135 citations

Quantification of apo[a] and apoB in human atherosclerotic lesions.

1991 • 132 citations

A novel mechanism by which probucol lowers low density lipoprotein levels demonstrated in the LDL receptor-deficient rabbit.

1984 • 127 citations

Effects of probucol on low density lipoprotein removal and high density lipoprotein synthesis

1981 • 121 citations

Antioxidant activity of probucol and its analogs in hypercholesterolemic Watanabe rabbits

1991 • 116 citations

Mechanisms of HDL reduction after probucol. Changes in HDL subfractions and increased reverse cholesteryl ester transfer.

1989 • 113 citations

Chronic renal failure: pathophysiology

1991 • 108 citations

Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro: probucol degradation precedes lipoprotein oxidation.

1989 • 107 citations

Lack of effect of probucol on atheroma formation in cholesterol-fed rabbits kept at comparable plasma cholesterol levels

1989 • 102 citations

Lipid peroxidation associated with successful thrombolysis

1990 • 101 citations

Inhibition by probucol of interleukin 1 secretion and its implication in atherosclerosis

1988 • 99 citations

Influence of probucol on cholesterol and lipoprotein metabolism in man.

1984 • 96 citations

Increase in plasma cholesteryl ester transfer protein during probucol treatment. Relation to changes in high density lipoprotein composition.

1991 • 94 citations

Oxidative modification of lipoprotein(a) and the effect of β-carotene

1992 • 94 citations

The effects of probucol on the progression of atherosclerosis in mature Watanabe heritable hyperlipidaemic rabbits

1991 • 93 citations

Effect of probucol on the physical properties of low-density lipoproteins oxidized by copper

1989 • 90 citations

Modification of chemically induced diabetes in rats by vitamin E. Supplementation minimizes and depletion enhances development of diabetes.

1983 • 89 citations

Diet and drugs in atherosclerosis.

1980 • 88 citations

Probucol prevents oxidative injury to endothelial cells.

1991 • 85 citations

Selective reduction of cholesterol in HDL2 fraction by probucol in familial hypercholesterolemia and hyperHDL2 cholesterolemia with abnormal cholesteryl ester transfer

1988 • 84 citations

Apolipoprotein C-III(Lys58----Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia.

1991 • 83 citations

Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. III. The protective effect of antioxidants (probucol, catechin, vitamin E) against the cytotoxicity of oxidized LDL occurs in two different ways

1991 • 82 citations

Detection of new epitopes formed upon oxidation of low-density lipoprotein, lipoprotein (a) and very-low-density lipoprotein. Use of an antiserum against 4-hydroxynonenal-modified low-density lipoprotein

1990 • 80 citations

Decreased plasma phosphatidylcholine/free cholesterol ratio as an indicator of risk for ischemic vascular disease.

1982 • 79 citations

The hypolipidemic action of probucol: a study of its effects on high and low density lipoproteins.

1983 • 78 citations

Probucol treatment affects the cellular composition but not anti-oxidized low density lipoprotein immunoreactivity of plaques from Watanabe heritable hyperlipidemic rabbits.

1991 • 73 citations

Interaction between low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) alleles contributes to normal variation in lipid level

1989 • 72 citations

Apolipoprotein E polymorphism and plasma cholesterol response to probucol

1987 • 70 citations

Mode of action of a new hypocholesteraemic drug (DH-581) in familial hypercholesteraemia

1972 • 70 citations

Probucol prevents lipid storage in macrophages

1986 • 69 citations

Probucol

1978 • 68 citations

The partial protective effect of the hydroxyl radical scavenger dimethyl urea on streptozotocin-induced diabetes in the mouse in vivo and in vitro

1982 • 63 citations

Effect of probucol treatment on the susceptibility of low density lipoprotein isolated from hypercholesterolemic patients to become oxidatively modified in vitro

1990 • 62 citations

Development of femoral atherosclerosis in hypercholesterolemic patients during treatment with cholestyramine and probucol/placebo: Probucol quantitative regression Swedish trial (PQRST): A status report

1988 • 61 citations

Renal vasoconstriction caused by short-term cholesterol feeding is corrected by thromboxane antagonist or probucol.

1990 • 61 citations

Intensive combination drug therapy of familial hypercholesterolemia with lovastatin, probucol, and colestipol hydrochloride.

1989 • 59 citations

Effects of membrane-stabilizing agents, cholesterol and cepharanthin, on radiation-induced lipid peroxidation and permeability in liposomes

1982 • 59 citations

Prevention of atherosclerotic progression in Watanabe rabbits by probucol

1988 • 57 citations

Influence of 4,4'-(Isopropylidenedithio)bis(2,6-di-t-butylphenol) (DH-581) on Experimental Atherosclerosis in Rabbits

1971 • 51 citations

Probucol, a superoxide free radical scavenger in vitro

1991 • 48 citations

Effect of probucol on development of diabetes mellitus in BB rats

1988 • 45 citations

Effect of Probucol, Pantethine and Their Combinations on Serum Lipoprotein Metabolism and on the Incidence of Atheromatous Lesions in the Rabbit

1986 • 44 citations

Probucol enhances cholesterol efflux from cultured human skin fibroblasts

1988 • 42 citations

Comparison of gas chromatography and high-performance liquid chromatography for the analysis of probucol in plasma

1986 • 42 citations

Prolongation of the QT interval induced by probucol: Demonstration of a method for determining QT interval change induced by a drug

1984 • 40 citations

Effect of probucol treatment on lipoprotein cholesterol and drug levels in blood and lipoproteins in familial hypercholesterolemia

1986 • 39 citations

Effect of long-term antihypertensive and hypolipidemic treatment on high density lipoprotein cholesterol and apolipoproteins A-I and A-II

1980 • 38 citations

Probucol with Colestipol in the Treatment of Hypercholesterolemia

1984 • 38 citations

The effects of probucol on plasma lipoproteins in polygenic and familial hypercholesterolaemia

1982 • 38 citations

Effect of Probucol on Hyperlipidemia in Patients with Nephrotic Syndrome

1987 • 37 citations

Long‐Term Oral Administration of Probucol [4, 4‘‐(Isopropylidenedithio) bis (2, 6‐di‐t‐Butylphenol)] (DH‐581) in the Management of Hypercholesterolemia*

1974 • 36 citations

Long-term use of probucol in the multifactorial primary prevention of vascular disease

1986 • 35 citations

Phenothiazines inhibit copper and endothelial cell-induced peroxidation of low density lipoprotein

1990 • 33 citations

Comparison of lovastatin and probucol in treatment of familial and non-familial hypercholesterolemia: different effects on lipoprotein profiles

1988 • 33 citations

Effect of probucol on cholesterol synthesis, plasma lipoproteins and the activities of lipoprotein and hepatic lipase in the rat

1981 • 33 citations

Effects of probucol on plasma lipids and lipoproteins in familial hypercholesterolemic patients with and without apolipoprotein E4

1990 • 33 citations

Probucol decreases apolipoprotein A-I transport rate and increases high density lipoprotein cholesteryl ester fractional catabolic rate in control and human apolipoprotein A-I transgenic mice.

1991 • 33 citations

QT prolongation and arrhythmia suppression

1985 • 32 citations

Changes in high-density lipoprotein subfraction distribution and increased cholesteryl ester transfer after probucol

1988 • 32 citations

Probucol treatment in hypercholesterolemic patients: effects on lipoprotein composition, HDL particle size, and cholesteryl ester transfer

1990 • 32 citations

Sensitization to epinephrine-induced ventricular fibrillation produced by probucol in dogs

1973 • 31 citations

Evaluation of the method of insulin binding studies in human erythrocytes.

1980 • 30 citations

Effects of combined probucol-colestipol treatment for familial hypercholesterolemia and coronary artery disease

1986 • 29 citations

Characterization of the specific binding of rat apolipoprotein E-deficient HDL to rat hepatic plasma membranes

1987 • 28 citations

Influence of probucol on early experimental atherogenesis in hypercholesterolemic rats

1989 • 28 citations

Probucol-induced QT prolongation and torsades de pointes.

1989 • 28 citations

Diet and probucol in lowering cholesterol concentrations. Additive effects on plasma cholesterol concentrations in patients with familial type ii hyperlipoproteinemia

1977 • 27 citations

The hypolipidemic action of probucol

1985 • 27 citations

Effect of probucol on the activity of postheparin plasma lipoprotein lipase and hepatic lipase

1981 • 27 citations

Probucol protects lipoprotein(a) against oxidative modification

1992 • 27 citations

Synthesis and hypocholesterolemic activity of alkylidenedithio bisphenols

1970 • 27 citations

The Lowering Effect of Probucol on Plasma Lipoprotein and Proteinuria in Puromycin Aminonucleoside-Induced Nephrotic Rats

1991 • 26 citations

Probucol Reduces Myocardial Dysfunction During Reperfusion After Short-Term Ischemia in Rabbit Heart

1991 • 25 citations

Primary Hyperlipoproteinemias

1992 • 25 citations

Electrocardiographic effects of probucol. A controlled prospective clinical trial

1984 • 25 citations

Probucol does not affect lipoprotein metabolism in macrophages of Watanabe heritable hyperlipidemic rabbits.

1989 • 24 citations

Role of cholesteryl ester transfer protein in reverse cholesterol transport

1991 • 24 citations

Inhibition by antioxidants of agonist evoked cytosolic Ca++ increase, ATP secretion and aggregation of aspirinated human platelets

1986 • 23 citations

A little more information about aggravation of probucol-induced HDL-reduction by clofibrate

1988 • 23 citations

Biochemical and pathological features of a modified strain of Watanabe heritable hyperlipidaemic rabbits

1988 • 23 citations

Antiatherosclerotic effect of probucol in WHHL rabbits: are there plasma parameters to evaluate this effect?

1991 • 21 citations

Probucol in long-term treatment of hypercholesterolemia

1988 • 20 citations

Probucol reduces the rate of association of apolipoprotein C-III with dimyristoylphosphatidylcholine

1988 • 19 citations

Medical management of hyperlipidemia and the role of probucol

1986 • 19 citations

The prolonged QT interval—a frequently unrecognized abnormality

1985 • 19 citations

Structural changes in oxidised low‐density lipoproteins and of the effect of the anti‐atherosclerotic drug probucol observed by synchrotron X‐ray and neutron solution scattering

1989 • 18 citations

Protective effect of probucol on alloxan diabetes in rats

1989 • 18 citations

The additive effect of probucol on diet in hyperlipidemia

1974 • 16 citations

Probucol enhances cholesterol transport in cultured rat hepatocytes

1988 • 16 citations

Controlled studies of the efficacy and safety of combined probucol-colestipol therapy

1986 • 16 citations

Probucol and its Mechanisms for Reducing Atherosclerosis

1990 • 14 citations

Effects of probucol on plasma lipoprotein subfractions and activities of lipoprotein lipase and hepatic triglyceride lipase

1991 • 14 citations

The long-term effects of probucol on serum lipid levels

1981 • 12 citations

Probucol attenuated hyperglycemia in multiple low-dose streptozotocin-induced diabetic mice

1991 • 12 citations

Decreased serum cholesteryl-ester transfer activity in a patient with familial hyperalphalipoproteinemia.

1988 • 12 citations

Influence of probucol administration on lipoprotein cholesterol and apolipoproteins in normolipemic males

1988 • 11 citations

Effect of probucol on triglyceride turnover in streptozotocin-diabetic rats

1991 • 10 citations

Probucol does not alter acetylated low density lipoprotein uptake by murine peritoneal macrophages

1990 • 9 citations

Clinical and therapeutic use of probucol

1991 • 8 citations

Stenosis following laser thermal angioplasty—A blinded controlled randomized study between aspirin against probucol

1991 • 4 citations

Probucol (Lorelco) in treatment of hyperlipemia

1977 • 3 citations

Influence of Oxidized LDL on Insulin Binding by IM-9 Lymphocytes

1988 • 1 citations

Mechanisms of Low Density Lipoprotein Lowering by Hypolipidemic Agents

1991 • 1 citations

Indications for lipid-lowering drugs

1991 • 1 citations