Interactions Between Acetylcholine and Dopamine in the Basal Ganglia

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists

1957 • 1,233 citations

Ascending Monoamine Neurons to the Telencephalon and Diencephalon

1966 • 1,205 citations

THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS

1967 • 1,116 citations

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

1975 • 874 citations

Huntington's Chorea

1973 • 845 citations

Demonstration and mapping out of nigro-neostriatal dopamine neurons

1964 • 796 citations

Psychiatric Aspects of Neurologic Disease

1976 • 674 citations

Self-inhibition by Dopaminergic Neurons

1975 • 645 citations

Memory and cognitive function in man

1977 • 624 citations

Cholinergic mechanisms in the control of behavior by the brain.

1963 • 542 citations

GABA in nervous system function

1976 • 529 citations

HUNTINGTON'S CHOREA

1974 • 527 citations

GABA in Nervous System Function

1977 • 503 citations

Antischizophrenic Drugs and Brain Cholinergic Receptors

1974 • 474 citations

ENZYMES ASSOCIATED WITH THE METABOLISM OF CATECHOLAMINES, ACETYLCHOLINE AND GABA IN HUMAN CONTROLS AND PATIENTS WITH PARKINSON'S DISEASE AND HUNTINGTON'S CHOREA

1976 • 452 citations

ISOLATION OF SYNAPTIC VESICLES AND STRUCTURAL ORGANIZATION OF THE ACETYLCHOLINE SYSTEM WITHIN BRAIN NERVE ENDINGS*

1963 • 435 citations

Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity

1972 • 421 citations

Anesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microelectrophoresis.

1965 • 395 citations

Third symposium on Parkinson's disease

1970 • 394 citations

The neurochemistry of Parkinson's disease: effect of L-dopa therapy.

1975 • 386 citations

Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism

1974 • 382 citations

The connexions of the striatum and globus pallidus: synthesis and speculation

1971 • 379 citations

Antiparkinsonian Drugs: Inhibition of Dopamine Uptake in the Corpus Striatum as a Possible Mechanism of Action

1969 • 348 citations

INFLUENCE OF THE SUBSTANTIA NIGRA ON THE CATECHOLAMINE CONTENT OF THE STRIATUM

1965 • 340 citations

Cholinergic-Anticholinergic Antagonism in Parkinsonism

1967 • 337 citations

The pathogenesis of Parkinson's disease: a new hypothesis.

1962 • 337 citations

Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?

1973 • 336 citations

Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat

1969 • 331 citations

DOPAMINE IN THE BASAL GANGLIA: Its Role and Therapeutic Implications (Including the Clinical Use of L-DOPA)

1973 • 316 citations

Choline acetyltransferase activity and mass fragmentographic measurement of acetylcholine in specific nuclei and tracts of rat brain

1975 • 280 citations

The action of dopamine on neurones of the caudate nucleus

1967 • 280 citations

Sympathetic Postganglionic Mechanism

1959 • 280 citations

Neostriatal choline acetylase and cholinesterase following selective brain lesions

1971 • 279 citations

Caudate nucleus neurones: correlation of the effects of substantia nigra stimulation with iontophoretic dopamine

1970 • 271 citations

Influences of cholinergic mechanisms on the function and turnover of brain dopamine

1971 • 266 citations

Enhanced striatal acetylcholine release by chlorpromazine and its reversal by apomorphine

1973 • 263 citations

Akinesia

1975 • 257 citations

Tolerance phenomena with neuroleptics catalepsy, apomorphine stereotypies and striatal dopamine metabolism in the rat after single and repeated administration of loxapine and haloperidol

1973 • 256 citations

Dopaminergic hypersensitivity and cholinergic hypofunction in the pathophysiology of tardive dyskinesia

1974 • 245 citations

Involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat.

1977 • 237 citations

Muscarinic cholinergic receptor binding: regional distribution in monkey brain

1974 • 236 citations

Effects of dopaminergic receptor agonists and antagonists on the activity of the neo-striatal cholinergic system

1975 • 236 citations

Choline acetylase in the central nervous system of man and some other mammals

1956 • 231 citations

Stimulation of Caudate Nucleus

1961 • 231 citations

Effect of drugs used in psychoses on cerebral dopamine metabolism

1970 • 226 citations

L-Dopa and Parkinsonism

1970 • 221 citations

Localization of cholinergic muscarinic receptors in rat brain by light microscopic radioautography

1976 • 219 citations

Book Review: Third Symposium on Parkinson's Disease

1970 • 215 citations

Excitatory nature of dopamine in the nigro-caudate pathway

1976 • 212 citations

PRESENT VIEWS ON THE MODE OF ACTION OF ACETYLCHOLINE IN THE CENTRAL NERVOUS SYSTEM

1945 • 210 citations

Interaction between cholinergic and catecholaminergic neurones in rat brain

1972 • 208 citations

Drug-Induced Extrapyramidal Reactions

1961 • 199 citations

Cholinesterase and succinic dehydrogenase in the central nervous system of the dog

1951 • 198 citations

Catalepsy and circling behaviour after intracerebral injections of neuroleptic, cholinergic and anticholinergic agents into the caudate-putamen, globus pallidus and substantia nigra of rat brain

1972 • 197 citations

THE INHIBITION OF THE CONDITIONED RESPONSE AND THE COUNTERACTION OF SCHIZOPHRENIA BY MUSCARINIC STIMULATION OF THE BRAIN

1957 • 191 citations

The Pathophysiologic Basis of Tardive Dyskinesia

1980 • 190 citations

The central effects of scopolamine in man.

1971 • 190 citations

Effect of cholinergic and anticholinergic agents on tardive dyskinesia

1974 • 188 citations

THE EFFECTS OF DIISOPROPYLFLUOROPHOSPHONATE IN SCHIZOPHRENIA AND MANIC DEPRESSIVE PSYCHOSIS

1950 • 188 citations

Cholinergic Mechanism in Brain inhibiting Amphetamine‐induced Stereotyped Behaviour

1968 • 187 citations

Choline acetyltransferase content of limbic nuclei of the rat

1974 • 185 citations

Biochemical abnormalities in Huntington's chorea brains

1974 • 185 citations

Nicotinic effect of acetylcholine on the release of newly synthesized [3H]dopamine in rat striatal slices and cat caudate nucleus

1976 • 180 citations

Choline acetylase and glutamic acid decarboxylase in Huntington's chorea

1973 • 180 citations

Evidence for glutamic acid decarboxylase-containing interneurons in the neostriatum

1975 • 179 citations

Origin and modulation of acetylcholine activity in the neostriatum

1974 • 174 citations

Immunohistochemical localization of choline acetyltransferase containing neostriatal neurons and their relationship with dopaminergic synapses

1976 • 169 citations

Cholinergic- and neuroleptic-induced catalepsy: Modification by lesions in the caudate-putamen

1971 • 161 citations

Influence of noncholinergic drugs on rat striatal acetylcholine levels

1974 • 160 citations

L-Dopa and Parkinsonism.

1971 • 157 citations

Temporal changes in amine synthesizing enzymes of rat extrapyramidal structures after hemitransections or 6-hydroxydopamine administration

1973 • 157 citations

Oral Choline Administration to Patients with Tardive Dyskinesia

1977 • 156 citations

Central Effects of Anticholinergic Drugs Measured by the Apomorphine Gnawing Test in Mice

1969 • 155 citations

Biology of cholinergic function

1976 • 154 citations

Clinical response and plasma levels: effect of dose, dosage schedules, and drug interactions on plasma chlorpromazine levels

1976 • 153 citations

Choline in tardive dyskinesia and Huntington's disease

1976 • 152 citations

Central cholinergic‐anticholinergic antagonism in Huntington's chorea

1972 • 150 citations

In vivo inhibition of striatal acetylcholine turnover by L-DOPA, apomorphine and (+)-amphetamine

1975 • 145 citations

A comparative study of haloperidol and chlorpromazine in terms of clinical effects and therapeutic reversal with benztropine in schizophrenia. Theoretical implications for potency differences among neuroleptics

1975 • 142 citations

Choline Administration: Activation of Tyrosine Hydroxylase in Dopaminergic Neurons of Rat Brain

1976 • 137 citations

Tricyclic Antidepressant Poisoning

1974 • 135 citations

γ-Aminobutyric Acid and a Caudato-Nigral Inhibition

1971 • 135 citations

Antagonistic Effects of Physostigmine and Methylphenidate in Man

1973 • 131 citations

Regional distribution of choline acetyltransferase and acetylcholinesterase within the amygdaloid complex and stria terminalis system

1977 • 130 citations

Influence of drugs on striatal and limbic homovanillic acid concentration in the rat brain

1975 • 128 citations

The influence of microelectrophoretically applied biogenic amines, cholinomimetics and procaine on synaptic excitation in the corpus striatum

1968 • 124 citations

Cholinergic mechanisms in the caudate nucleus

1966 • 124 citations

The demonstration of acetylcholinesterase containing neurones within the caudate nucleus of the rat

1972 • 124 citations

The pharmacology of extrapyramidal movement disorders.

1973 • 122 citations

DISTRIBUTION OF CHOLINE ACETYLTRANSFERASE AND GLUTAMATE DECARBOXYLASE WITHIN THE SUBSTANTIA NIGRA AND IN OTHER BRAIN REGIONS FROM CONTROL AND PARKINSONIAN PATIENTS

1975 • 122 citations

Possible dopaminergic pathway from substantia nigra to putamen

1970 • 120 citations

Neuroleptic and non-neuroleptic catalepsy.

1973 • 118 citations

Evaluating the Long-Term Need for Antiparkinson Drugs by Chronic Schizophrenics

1972 • 113 citations

Cholinergic and dopaminergic mechanisms in Huntington's chorea

1971 • 112 citations

Cholinesterasic striatopallidal and striatonigral efferents in the cat and the monkey

1970 • 110 citations

Picrotoxin antagonism of γ aminobutyric acid inhibitory responses and synaptic inhibition in the rat substantia nigra

1973 • 110 citations

Involvement of brain cholinergic mechanisms in the action of chlorpromazine

1974 • 110 citations

Recent Advances in Parkinson's Disease.

1972 • 106 citations

Drug-induced extrapyramidal disorders.

1972 • 106 citations

Biology of Cholinergic Function

1977 • 100 citations

Rotational behavior induced in rats by intranigral picrotoxin

1975 • 94 citations

Changes in neostriatal da metabolism after carbachol or atropine microinjections into the substantia nigra

1974 • 93 citations

Therapeutic Approaches to Tardive Dyskinesia

1972 • 88 citations

Cataleptic state and hypothermia in mice, caused by central cholinergic stimulation and antagonized by anticholinergic and antidepressant drugs

1968 • 87 citations

Inhibitory influence of the nigrostriatal dopamine system on the striatal cholinergic neurons in the rat

1975 • 86 citations

Acetylcholinesterase-containing neurons in the neostriatum and substantia nigra revealed after punctate intracerebral injection of di-isopropylfluorophosphate

1975 • 85 citations

Cholinergic link hypothesis in adrenergic neuroeffector transmission.

1966 • 85 citations

Fine structural synaptic organization of the corpus striatum and substantia nigra in rat and cat.

1975 • 85 citations

Implications of Amphetamine-Induced Stereotyped Behavior as a Model for Tardive Dyskinesias

1972 • 84 citations

The effect of L-3, 4-dihydroxyphenylalanine and DL-5- -hydroxytryptophan on rigidity and tremor induced by reserpine, chlorpromazine and phenoxybenzamine

1964 • 80 citations

Physostigmine in choreiform movement disorders

1974 • 80 citations

The inhibitory action of dopamine on neurones of the caudate nucleus

1967 • 77 citations

Cholinergic antagonism of methylphenidate-induced stereotyped behavior

1972 • 76 citations

Modification of striatal acetylcholine concentration by dopamine receptor agonists and antagonists.

1974 • 74 citations

The tardive dyskinesia syndrome.

1978 • 73 citations

Postnatal development of dopaminergic and cholinergic catalepsy in the rat

1976 • 73 citations

The Abrupt Withdrawal of Antiparkinsonian Drugs in Schizophrenic Patients

1974 • 72 citations

Increased release of dopamine from striatal dopaminergic terminals in the rat after treatment with a neuroleptic: Thioproperazine

1970 • 70 citations

Antiparkinson Drug Overuse

1970 • 69 citations

Amine synthesis in various brain regions with caudate or septal lesions

1969 • 67 citations

THERAPEUTIC REVERSAL WITH BENZTROPINE IN SCHIZOPHRENICS

1975 • 67 citations

Cholinergic Enzyme Systems in Parkinson's Disease

1971 • 67 citations

DOPAMINE ACETYLCHOLINE IMBALANCE IN PARKINSON'S DISEASE

1976 • 64 citations

Analysis of the tremor induced by injection of cholinergic agents into the caudate nucleus

1966 • 64 citations

Withdrawal of Antiparkinson Drugs

1971 • 63 citations

Drug-induced changes of dopamine turnover in striatum and limbic system of the rat

1975 • 63 citations

Cholinergic and anticholinergic influences on amphetamine-induced stereotyped behavior

1972 • 62 citations

THE INTERACTION OF NEUROLEPTIC AND MUSCARINIC AGENTS WITH CENTRAL DOPAMINERGIC SYSTEMS

1975 • 62 citations

Role of nigro-neostriatal dopaminergic fibers in compulsive gnawing behavior in rats

1966 • 61 citations

Reciprocal Effects on α‐ and γ‐Motoneurones of Drugs Influencing Monoaminergic and Gholinergic Transmission

1966 • 59 citations

Decreased muscarinic receptor concentration in post-mortem brain in Huntington's chorea

1974 • 58 citations

ABNORMAL INVOLUNTARY MOVEMENTS INDUCED BY ANTICHOLINERGIC THERAPY

2009 • 58 citations

Parkinsonism: physiology, pharmacology and treatment

1970 • 58 citations

Feedback control of dopamine synthesis in dopaminergic terminals of the rat striatum.

1972 • 57 citations

Influence of antiparkinson drugs and amphetamine on some pharmacological effects of Phenothiazine derivatives used as neuroleptics

1964 • 57 citations

Atropine-induced changes of cerebral dopamine turnover

1971 • 57 citations

Decrease in rat striatal acetylcholine levels by some direct- and indirect-acting dopaminergic antagonists

1975 • 56 citations

Effects of antiparkinson drugs on a phenothiazine-induced catatonic reaction.

1962 • 56 citations

Neurochemical evidence for denervation supersensitivity: The effect of unilateral substantia nigra lesions on apomorphine-induced increases in neostriatal acetylcholine levels

1974 • 55 citations

Effect of some antiparkinsonian drugs on catecholamine neurons

1970 • 55 citations

Regional distribution of choline acetylase in the brain of the rhesus monkey

1968 • 55 citations

Cytochemical and electrophysiological studies of dopamine in the caudate nucleus.

1976 • 53 citations

Rotational behaviour following inhibition of GABA metabolism unilaterally in the rat substantia nigra

1975 • 52 citations

The Pharmacology of Extrapyramidal Movement Disorders

1973 • 52 citations

Effects of peripheral and local administration of picrotoxin on the release of newly synthesized 3H-dopamine in the caudate nucleus of the cat

1977 • 50 citations

Recent Advances in Parkinson's Disease

1972 • 48 citations

Effects of oxotremorine and physostigmine on the turnover of dopamine in the corpus striatum and the limbic system

1974 • 47 citations

Drug-Induced Extrapyramidal Symptoms and Their Relations to Clinical Efficacy

1967 • 46 citations

Transmitters and identified neurons in the mammalian central nervous system

1975 • 44 citations

ANTIPARKINSON DRUGS AS CAUSAL AGENTS IN TARDIVE DYSKINESIA

1973 • 43 citations

Interaction of atropine‐like drugs with dopamine‐containing neurones in rat brain

1972 • 42 citations

Amphetamine-induced inhibition of tyrosine hydroxylation in homogenates of rat corpus striatum

1975 • 42 citations

Levodopa and cholinergic hypersensitivity in Parkinson's disease

1972 • 42 citations

Oxotremorine- and atropine-induced changes of dopamine metabolism in the rat striatum

1975 • 41 citations

Effects of dopaminergic drugs and acute medial forebrain bundle lesions on striatal acetylcholine levels

1975 • 40 citations

THE EFFECTS OF ACETYLCHOLINE AND DOPAMINE ON THE CAUDATE NUCLEUS DEPLETED OF BIOGENIC AMINES

1975 • 39 citations

PARKINSONISM: Physiology, Pharmacology and Treatment

1971 • 38 citations

The effect of manipulation of cholinergic mechanisms on turning behaviour in mice with unilateral destruction of the nigro-neostriatal dopaminergic system

1978 • 37 citations

Tricyclic antidepressant poisoning. Reversal of coma, choreoathetosis, and myoclonus by physostigmine

1974 • 36 citations

The effects of physostigmine in phenothiazine resistant chronic schizophrenic patients: Preliminary observations

1973 • 36 citations

CONTROLLED STUDIES OF ANTIPARKINSONISM AGENTS IN THE TREATMENT OF DRUG-INDUCED EXTRAPYRAMIDAL SYMPTOMS

1970 • 35 citations

Influence of the antiparkinsonian drugs on the plasma level of neuroleptics.

1977 • 35 citations

Choline therapy in Huntington chorea

1977 • 35 citations

Is the central cholinergic nervous system overexploited?

1969 • 34 citations

6-Hydroxydopamine and striatal acetylcholine levels

1974 • 33 citations

Neurotransmitter Function--Basic and Clinical Aspects

1978 • 33 citations

Reversal by Levodopa of Cholinergic Hypersensitivity in Parkinson's Disease

1971 • 32 citations

Inhibition of anticholinergic drug-induced locomotor stimulation in mice by α-methyltyrosine

1973 • 32 citations

Central dopaminergic neurons: Neurophysiological identification and responses to drugs

1974 • 31 citations

Reversal by 3,4-dihydroxyphenylalanine of reserpine-induced regional changes in acetylcholine content in guinea-pig brain

1966 • 30 citations

Deanol Acetamidobenzoate Treatment in Choreiform Movement Disorders

1977 • 29 citations

Differential antagonism by the anticholinergic dexetimide of inhibitory effects of haloperidol and fentanyl on brain self-stimulation

1975 • 28 citations

BRAIN ACETYLCHOLINESTERASE IN PARKINSON'S DISEASE

2009 • 28 citations

ABNORMAL INVOLUNTARY MOVEMENTS IN RELATION TO ANTICHOLINERGICS AND LEVODOPA THERAPY

1975 • 27 citations

Antiparkinsonian drugs and central dopamine neurons

1970 • 27 citations

A longitudinal therapeutic comparison between two prototypic neuroleptics (haloperidol and chlorpromazine) in matched groups of schizophrenics. Nontherapeutic interactions with trihexyphenidyl. Theoretical implications for potency differences

1975 • 26 citations

The effect of antipsychotic drugs on the firing of dopaminergic neurons. A reappraisal

1974 • 24 citations

Enhancement of tyrosine hydroxylation within the brain by chlorpromazine

1969 • 24 citations

?In vivo? release of endogenous neurotransmitters in cat limbic regions: Effect of chlorpromazine and of electrical stimulation

1975 • 23 citations

Regulation of catecholamine release. The muscarinic inhibitory mechanism

1973 • 21 citations

Physostigmine Effects on Phenothiazine-Induced Extrapyramidal Reactions

1973 • 21 citations

Integrated effect of psychotropic drugs on the balance of cholino-, adreno-, and serotoninergic processes in the brain as a basis of their gross behavioral and therapeutic actions.

1967 • 20 citations

Extrapyramidal Side Effects in Chlorpromazine Recipients

1977 • 19 citations

Comparison of the effects of the intranigral injections of cholinomimetics with systemic injections of the dopamine receptor stimulating and blocking agents in the rabbit

1974 • 19 citations

The development of animal models for studies in Parkinson's disease.

1971 • 19 citations

Ontogenesis of neostriatal cholinergic neurones in the rat and development of their sensitivity to neuroleptic drugs

1975 • 19 citations

Modification of the tremorigenic activity of physostigmine

1972 • 18 citations

Pheniramine Aminosalicylate Overdosage

1977 • 17 citations

Regulation of catecholamine release

1973 • 16 citations

CHEMICAL STRUCTURE OF SUBSTANCES EFFECTIVE IN TREATMENT OF PARKINSONISM

1950 • 16 citations

Dopamine receptors and cholinergic neurons in the rat neostriatum.

1975 • 15 citations

Reversal by a central antiacetylcholine drug of pimozideinduced inhibition of mouse-jumping in amphetamine-dopa treated mice

1975 • 15 citations

Pharmacological evidence for a cholinergic mechanism in brain involved in a special stereotyped behaviour of reserpinized rats.

1968 • 15 citations

Clinical Neuropharmacology, Vol. 1

1977 • 15 citations

Cholinergic systems in extrapyramidal function.

1976 • 12 citations

Cyclizine-induced chorea

1977 • 12 citations

5‐Hydroxytryptamine and monoamine oxidase in developing chick spinal cord

1975 • 11 citations

Cholinergic modification of abnormal involuntary movements induced in the guinea-pig by intrastriatal dopamine

1975 • 11 citations

Proceedings: The effect of cholinergic and anticholinergic drugs on rotational behaviour in mice with destruction of one nigrostriatal pathway.

1975 • 5 citations

Cholinergic-dopaminergic relation in different brain structures

1974 • 5 citations

Interaction of neuroleptic and cholinergic drugs with central dopaminergic mechanisms

1974 • 4 citations

The effects of salicylate on guinea-pig testis mitochondria compared with the effects of aging and repeated washing

1966 • 2 citations

Possible chemical mediators of synaptic action in certain basal ganglial pathways.

1971 • 2 citations

Deleted Work

1955 • 0 citations