L-Dopa and Parkinsonism

Tyrosine Hydroxylase

1964 • 2,038 citations

Verteilung Von Noradrenalin Und Dopamin (3-Hydroxytyramin) Im Gehirn Des Menschen Und Ihr Verhalten Bei Erkrankungen Des Extrapyramidalen Systems

1960 • 1,863 citations

Aromatic Amino Acids and Modification of Parkinsonism

1967 • 1,464 citations

6-hydroxy-dopamine induced degeneration of central monoamine neurons

1968 • 1,419 citations

Modification of Parkinsonism — Chronic Treatment with L-Dopa

1969 • 1,253 citations

Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-hydroxydopamine

1968 • 862 citations

A Neurological Syndrome Associated with Orthostatic Hypotension

1960 • 737 citations

The occurrence, distribution and physiological role of catecholamines in the nervous system.

1959 • 665 citations

Treatment of Parkinsonism With Levodopa

1969 • 602 citations

Amantadine in the Treatment of Parkinson's Disease

1969 • 599 citations

In vitro studies on central and peripheral monoamine neurons at the ultrastructural level

1968 • 499 citations

B. TYROSINE HYDROXYLASE

1966 • 493 citations

The Enzymatic Conversion of 3,4-Dihydroxyphenylethylamine to Norepinephrine

1960 • 435 citations

Anesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microelectrophoresis.

1965 • 395 citations

Antiparkinsonian Drugs: Inhibition of Dopamine Uptake in the Corpus Striatum as a Possible Mechanism of Action

1969 • 348 citations

INFLUENCE OF THE SUBSTANTIA NIGRA ON THE CATECHOLAMINE CONTENT OF THE STRIATUM

1965 • 340 citations

Cholinergic-Anticholinergic Antagonism in Parkinsonism

1967 • 337 citations

The action of dopamine on neurones of the caudate nucleus

1967 • 280 citations

Similarities between Neurologic Effects of L-Dopa and of Apomorphine

1970 • 271 citations

Structure–Activity Relationships of One-Ring Psychotomimetics

1969 • 240 citations

Micro‐iontophoretic studies on neurones in the cuneate nucleus

1967 • 227 citations

Multiple Forms of Human Brain Mitochondrial Monoamine Oxidase

1970 • 227 citations

Mechanisms of Release of Biogenic Amines.

1967 • 222 citations

Drug-Induced Extrapyramidal Reactions

1961 • 199 citations

Cerebral accumulation and metabolism of C14-dopa after selective inhibition of peripheral decarboxylase.

1968 • 198 citations

Modification of Chronic Manganese Poisoning

1970 • 195 citations

Treatment of Parkinson's Syndrome with L Dihydroxyphenylalanine (Levodopa)

1970 • 184 citations

Decrease of cerebral 5-hydroxytryptamine by 3,4-dihydroxyphenylalanine after inhibition of extracerebral decarboxylase

1968 • 177 citations

Release into the cerebral ventricles of substances with possible transmitter function in the caudate nucleus

1969 • 162 citations

Chemical, Enzymatic and Metabolic Studies on the Mechanism of Oxidation of Dopamine¹

1959 • 160 citations

Selective depletion of caudate nucleus dopamine and serotonin during chronic manganese dioxide administration to squirrel monkeys

1969 • 158 citations

EFFECTS OF L-DOPA IN PARKINSON'S DISEASE

1969 • 157 citations

The decarboxylation of amino acids related to tyrosine and their awakening action in reserpine‐treated mice

1960 • 154 citations

Progress in Medicinal Chemistry.

1963 • 147 citations

L-DOPA IN POSTENCEPHALITIC PARKINSONISM

1969 • 144 citations

The metabolism of orally administered <scp>l</scp>‐DOPA in Parkinsonism

1969 • 135 citations

Hypotension Caused by L-Dopa

1970 • 128 citations

5-hydroxyindoleacetic and homovanillic acid levels in the cerebrospinal fluid of healthy volunteers and patients with Parkinson's syndrome

1967 • 126 citations

Cholinergic mechanisms in the caudate nucleus

1966 • 124 citations

L-DOPA IN IDIOPATHIC PARKINSONISM

1969 • 98 citations

CENTRAL MONOAMINE NEURONS**Abbreviations used: A, adrenaline; CA, catecholamine(s); CNS, central nervous system; COMT, catechol-o-methyltransferase; DA, dopamine; DOPA, 3,4-dihydroxyphenylalanine; FRA, flexor reflex afferents; 5-HT, 5-hydroxytryptamine; 5-HTP, 5-hydroxytryptophan; MAO, monoamine oxidase; NA, noradrenaline.

1966 • 95 citations

THE DISTRIBUTION OF TRYPTOPHAN HYDROXYLASE IN CAT BRAIN

1968 • 93 citations

Metabolism and storage of biogenic amines

1957 • 88 citations

Dopa decarboxylase: substrates, coenzyme, inhibitors.

1966 • 85 citations

Caudate Unit Responses to Nigral Stimuli: Evidence for a Possible Nigro-Neostriatal Pathway

1968 • 78 citations

Role of L-DOPA decarboxylase in the biosynthesis of catecholamines in nervous tissue and the adrenal medulla.

1959 • 76 citations

The low level of 5-hydroxytryptophan decarboxylase in human brain

1967 • 75 citations

Treatment of Parkinsonism with Laevo-Dopa

1970 • 73 citations

PSYCHOTROPIC DRUGS AND DYSFUNCTIONS OF THE BASAL GANGLIA

1971 • 71 citations

Drug-Induced Changes of Extracerebral Dopa Metabolism in Man

1969 • 68 citations

Further observations on the gas-chromatographic measurement of urinary phenolic and indolic metabolites

1969 • 59 citations

Reciprocal Effects on α‐ and γ‐Motoneurones of Drugs Influencing Monoaminergic and Gholinergic Transmission

1966 • 59 citations

The release of dopamine from the putamen

1965 • 57 citations

Biosynthesis of adrenaline and noradrenaline.

1959 • 54 citations

m -Hydroxyphenylacetic Acid Formation from L-Dopa in Man: Suppression by Neomycin

1969 • 51 citations

Gas chromatographic measurement of phenolic acids and alcohols in human urine

1968 • 48 citations

Metabolic Studies and Clinical Observations During L-Dopa Treatment of Parkinson's Disease

1970 • 47 citations

Substrate specificity of brain amine oxidase of several mammals

1960 • 45 citations

Adrenergic mechanisms

1961 • 42 citations

On the Occurrence of Homovanillic Acid and 5-Hydroxyindol-3-ylacetic Acid in the Ventricular C.S.F. of Patients Suffering from Parkinsonism

1967 • 41 citations

Dopamine (3-Hydroxytyramine) metabolism in parkinsonism

1969 • 37 citations

[Treatment of Parkinsonism with oral L-DOPA combined with a decarboxylase inhibitor (Ro IV 46.02)].

1969 • 33 citations

Drug-induced Relief of the Tremor in Monkeys with Mesencephalic Lesions

1969 • 19 citations

Multiple electrophoresis peaks of rat liver decarboxylases for 3,4-dihydroxyphenylalanine and 5-hydroxytryptophan

1969 • 14 citations

Sustaining Life During Fulminant Hepatic Failure

1969 • 10 citations