Comparative analysis of the plant mRNA-destabilizing element, DST, in mammalian and tobacco cells.

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

AU-rich elements: characterization and importance in mRNA degradation

1995 • 1,936 citations

mRNA stability in mammalian cells

1995 • 1,258 citations

Tobacco BY-2 Cell Line as the “HeLa” Cell in the Cell Biology of Higher Plants

1992 • 1,188 citations

Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

1998 • 1,139 citations

Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the invivo stability of ARE-containing mRNAs

1998 • 852 citations

RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein

1998 • 738 citations

Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

1999 • 725 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

Degradation of mRNA in eukaryotes

1995 • 648 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1.

1993 • 533 citations

Autoradiography using storage phosphor technology

1990 • 531 citations

The Nonamer UUAUUUAUU Is the Key AU-Rich Sequence Motif That Mediates mRNA Degradation

1995 • 524 citations

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

1991 • 487 citations

Deregulated c-fos expression interferes with normal bone development in transgenic mice

1987 • 337 citations

AUUUA Is Not Sufficient To Promote Poly(A) Shortening and Degradation of an mRNA: the Functional Sequence within AU-Rich Elements May Be UUAUUUA(U/A)(U/A)

1994 • 331 citations

The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins.

1997 • 329 citations

Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay

1997 • 302 citations

Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element

1999 • 294 citations

The SV40 enhancer is composed of multiple functional elements that can compensate for one another

1986 • 293 citations

Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae

1996 • 246 citations

ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system

1999 • 244 citations

Transcription, organization, and sequence of an auxin-regulated gene cluster in soybean.

1989 • 224 citations

DST sequences, highly conserved among plant SAUR genes, target reporter transcripts for rapid decay in tobacco.

1993 • 208 citations

Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.

1985 • 207 citations

The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA

1997 • 206 citations

Rapid Redistribution of Auxin-Rregulated RNAs During Gravitropism

1989 • 204 citations

GT-1 Binding Site Confers Light Responsive Expression in Transgenic Tobacco

1990 • 183 citations

A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsensecontaining mRNAs in mammalian cells

1998 • 181 citations

Purification, Characterization, and cDNA Cloning of an AU-Rich Element RNA-Binding Protein, AUF1

1993 • 177 citations

Regulation of mRNA turnover in eukaryotic cells.

1991 • 171 citations

Sequences in the pea rbcS-3A gene have homology to constitutive mammalian enhancers but function as negative regulatory elements.

1987 • 169 citations

Characterization of the Auxin-Inducible SAUR-AC1 Gene for Use as a Molecular Genetic Tool in Arabidopsis

1994 • 154 citations

A broader role for AU-rich element-mediated mRNA turnover revealed by a new transcriptional pulse strategy

1998 • 148 citations

The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation.

1990 • 146 citations

Premature nonsense codons decrease the stability of phytohemagglutinin mRNA in a position‐dependent manner

1996 • 115 citations

The effect of sequences with high AU content on mRNA stability in tobacco.

1993 • 115 citations

Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein.

1988 • 101 citations

Control of mRNA stability in higher plants

1996 • 98 citations

Multiple regions of the Arabidopsis SAUR-AC1 gene control transcript abundance: the 3′ untranslated region functions as an mRNA instability determinant.

1996 • 98 citations

The PUMILIO−RNA Interaction: A Single RNA-Binding Domain Monomer Recognizes a Bipartite Target Sequence

1998 • 94 citations

Functional analysis of a light-responsive plant bZIP transcriptional regulator.

1994 • 87 citations

Direct Evidence for Rapid Degradation ofBacillus thuringiensis Toxin mRNA as a Cause of Poor Expression in Plants1

1998 • 87 citations

Control of the Decay of Labile Proto-oncogene and Cytokine mRNAs

1993 • 64 citations

Mutational analysis of the DST element in tobacco cells and transgenic plants: identification of residues critical for mRNA instability.

1996 • 38 citations

Activation of the Transforming Potential of the Human fos Proto-Oncogene Requires Message Stabilization and Results in Increased Amounts of Partially Modified fos Protein

1988 • 24 citations