Analogs of Staurosporine

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization.

1977 • 659 citations

UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

1996 • 451 citations

Protein kinase C isozymes and substrates

1996 • 440 citations

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

1989 • 414 citations

Potent and Specific Inhibitors of Protein Kinase C of Microbial Origin

1990 • 262 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

1993 • 222 citations

Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor.

1996 • 221 citations

Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue.

1989 • 211 citations

The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase‐1β (Rsk‐2) and p70 S6 kinase

1997 • 206 citations

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1987 • 189 citations

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

1991 • 187 citations

Characterization of Phosphorylation-defective Mutants of Human P-glycoprotein Expressed in Mammalian Cells

1996 • 169 citations

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.

1989 • 156 citations

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.

1997 • 155 citations

Transfection with Protein Kinase Cα Confers Increased Multidrug Resistance to MCF-7 Cells Expressing P-Glycoprotein

1991 • 146 citations

Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis.

1996 • 145 citations

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.

1995 • 137 citations

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.

1993 • 133 citations

Protein Kinase C-mediated Phosphorylation Does Not Regulate Drug Transport by the Human Multidrug Resistance P-glycoprotein

1996 • 121 citations

Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

1993 • 119 citations

Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas.

1991 • 117 citations

UCN-01, 7-Hydroxyl-staurosporine, Inhibits Kinase Activity of Cyclin-Dependent Kinases and Reduces the Phosphorylation of the Retinoblastoma Susceptibility Gene Product in A549 Human Lung Cancer Cell Line

1996 • 117 citations

Induction of apoptosis in chronic lymphocytic leukemia cells and its prevention by phorbol ester

1992 • 110 citations

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation.

1989 • 107 citations

7-Hydroxystaurosporine (UCN-01) Induces Apoptosis in Human Colon Carcinoma and Leukemia Cells Independently of p53

1997 • 89 citations

Activation of protein kinase C subtypes α, γ, δ, ϵ, ζ, and η by tumor-promoting and nontumor-promoting agents

1997 • 87 citations

Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells.

1993 • 79 citations

UCN‐01, an anti‐tumor drug, is a selective inhibitor of the conventional PKC subfamily

1995 • 78 citations

How does p21ras transform cells?

1991 • 75 citations

Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation

1995 • 75 citations

Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor

1996 • 74 citations

7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells.

1997 • 74 citations

The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance

1994 • 73 citations

Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251.

1992 • 72 citations

Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression.

1992 • 70 citations

Structures of staurosporine bound to CDK2 and cAPK – new tools for structure-based design of protein kinase inhibitors

1997 • 64 citations

Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells

1996 • 62 citations

Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C

1994 • 56 citations

Differential inhibition of cytosolic and membrane‐derived protein kinase C activity by staurosporine and other kinase inhibitors

1995 • 46 citations

Co-ordinate loss of protein kinase C and multidrug resistance gene expression in revertant MCF-7/Adr breast carcinoma cells

1997 • 37 citations

Differing Effects of Staurosporine and UCN-01 on RB Protein Phosphorylation and Expression of Lung Cancer Cell Lines

1996 • 35 citations

Signal transduction for proliferation of glioma cells in vitro occurs predominantly through a protein kinase C-mediated pathway

1996 • 35 citations

Antitumor Effect of CGP41251, a New Selective Protein Kinase C Inhibitor, on Human Non-Small Cell Lung Cancer Cells

1996 • 34 citations

Chemosensitization of cancer cells by the staurosporine derivative CGP 41251 in association with decreased P-glycoprotein phosphorylation

1997 • 31 citations

Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells

1996 • 31 citations

Anticancer drugs acting against signaling pathways

1995 • 26 citations

Inhibition of the growth of glioblastomas by CGP 41251, an inhibitor of protein kinase C, and by a phorbol ester tumor promoter.

1996 • 26 citations

Characterisation of novel human lung carcinoma cell lines selected for resistance to anti-neoplastic analogues of staurosporine

1997 • 20 citations

Effects of protein kinase C inhibitor, staurosporine derivative CGP 41 251, on cell cycle, DNA synthesis and drug uptake in neoplastic cell lines

1995 • 18 citations

Protein kinase inhibitor-induced alterations of drug uptake, cell cycle and surface antigen expression in human multidrug-resistant (Pgp and MRP) promyelocytic leukemia HL-60 cells

1997 • 17 citations

Stimulation of 1-(beta-D-arabinofuranosyl)cytosine (AraC)-induced apoptosis in the multidrug resistant human promyelocytic leukemia cell lines with protein kinase inhibitors.

1996 • 14 citations

Effects of the new selective protein kinase C inhibitor 4'-N-benzoyl staurosporine on cell cycle distribution and growth inhibition in human small cell lung cancer cells.

1996 • 14 citations

Disposition in mice of 7-hydroxystaurosporine, a protein kinase inhibitor with antitumor activity

1994 • 13 citations

Deleted Work

1955 • 0 citations