Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization.

1977 • 659 citations

Lipid activation of protein kinase C.

1991 • 566 citations

The mechanism of protein kinase C activation

1989 • 423 citations

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and In vitro anti‐proliferative as well as In vivo anti‐tumor activity

1989 • 414 citations

K-252a, a potent inhibitor of protein kinase C from microbial origin.

1986 • 332 citations

‘Crosstalk’: a pivotal role for protein kinase C in modulating relationships between signal transduction pathways

1991 • 328 citations

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action

1988 • 190 citations

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1987 • 189 citations

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.

1989 • 156 citations

K-252b, c and d, potent inhibitors of protein kinase C from microbial origin.

1986 • 139 citations

The structures of the novel protein kinase C inhibitors K-252a, b, c and d.

1986 • 122 citations

Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors.

1990 • 96 citations

TAN-999 and TAN-1030A, new indolocarbazole alkaloids with macrophage-activating properties.

1989 • 62 citations

Kinetic analysis of protein kinase C inhibition by staurosporine: evidence that inhibition entails inhibitor binding at a conserved region of the catalytic domain but not competition with substrates.

1992 • 49 citations

Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C.

1990 • 45 citations

A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine) I. Screening, taxonomy, fermentation and biological activity.

1990 • 41 citations

A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity.

1992 • 41 citations

A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine) II. Isolation, physico-chemical properties and structure.

1990 • 39 citations

A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure.

1992 • 28 citations

A new inhibitor of protein kinase C, RK-1409B (4'-demethylamino-4'-hydroxy-3'-epistaurosporine).

1992 • 23 citations