Insulin-like Growth Factor I Receptors

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. 1956.

1990 • 1,075 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

1982 • 709 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

1983 • 395 citations

A Single Receptor Binds Both Insulin-Like Growth Factor II and Mannose-6-Phosphate

1988 • 363 citations

Direct Demonstration of Separate Receptors for Growth and Metabolic Activities of Insulin and Multiplication-stimulating Activity (an Insulinlike Growth Factor) Using Antibodies to the Insulin Receptor

1980 • 346 citations

Expression and characterization of a functional human insulin-like growth factor I receptor.

1988 • 313 citations

Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries.

1980 • 312 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Stimulation of tyrosine-specific phosphorylation in vitro by insulin-like growth factor I

1983 • 254 citations

Interactions of Insulin-Like Growth Factors I and II and Multiplication-Stimulating Activity with Receptors and Serum Carrier Proteins

1980 • 254 citations

Insulin receptor: covalent labeling and identification of subunits.

1979 • 243 citations

Insulin as a Potent, Specific Growth Factor in a Rat Hepatoma Cell Line

1981 • 221 citations

Structure of the Receptor for Insulin-Like Growth Factor II: The Puzzle Amplified

1988 • 206 citations

A PDGF receptor domain essential for mitogenesis but not for many other responses to PDGF

1988 • 196 citations

Photoaffinity labeling of insulin receptor proteins of liver plasma membrane preparations

1980 • 195 citations

Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.

1987 • 195 citations

Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor.

1988 • 190 citations

Distinct biologically active receptors for insulin, insulin-like growth factor I, and insulin-like growth factor II in cultured skeletal muscle cells.

1985 • 187 citations

Structural similarities between human receptors for somatomedin C and insulin: analysis by affinity labeling

1981 • 187 citations

Effects and Binding of Insulin-Like Growth Factor I in the Isolated Soleus Muscle of Lean and Obese Mice: Comparison with Insulin*

1979 • 176 citations

Evidence from Monoclonal Antibody Studies that Insulin Stimulates Deoxyribonucleic Acid Synthesis through the Type I Somatomedin Receptor*

1985 • 160 citations

The high affinity insulin receptor mediates growth stimulation in rat hepatoma cells.

1982 • 152 citations

Monensin blocks the maturation of receptors for insulin and somatomedin C: Identification of receptor precursors

1983 • 147 citations

The type II insulin-like growth factor receptor does not mediate increased DNA synthesis in H-35 hepatoma cells.

1984 • 145 citations

Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects.

1988 • 144 citations

Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor.

1981 • 136 citations

Non-parallel evolution of metabolic and growth-promoting functions of insulin

1981 • 129 citations

Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells.

1987 • 120 citations

Characterization of insulin-like growth factor I-stimulated tyrosine kinase activity associated with the beta-subunit of type I insulin-like growth factor receptors of rat liver cells.

1985 • 119 citations

The insulin receptor. Structural basis for high affinity ligand binding.

1987 • 117 citations

Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor

1988 • 106 citations

Insulin-like growth factor II binding to the type I somatomedin receptor. Evidence for two high affinity binding sites.

1986 • 104 citations

The type I insulin-like growth factor receptor mediates the rapid effects of multiplication-stimulating activity on membrane transport systems in rat soleus muscle.

1984 • 104 citations

Properties of a human insulin receptor with a COOH-terminal truncation. I. Insulin binding, autophosphorylation, and endocytosis.

1988 • 103 citations

Phosphorylation of receptors for insulin and insulin-like growth factor I. Effects of hormones and phorbol esters.

1986 • 102 citations

Isolation of functional alpha beta heterodimers from the purified human placental alpha 2 beta 2 heterotetrameric insulin receptor complex. A structural basis for insulin binding heterogeneity.

1987 • 99 citations

Effect of an anti-insulin-like growth factor I receptor antibody on insulin-like growth factor II stimulation of DNA synthesis in human fibroblasts

1986 • 98 citations

Structural requirements for the transmembrane activation of the insulin receptor kinase.

1986 • 93 citations

Insulin-like growth factor-I (IGF-I) stimulates tyrosine kinase activity in purified receptors from a rat liver cell line

1984 • 89 citations

Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors.

1983 • 85 citations

Insulin and insulinlike growth factor receptors and responses in cultured human muscle cells

1986 • 81 citations

Isolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/binding

1989 • 80 citations

Interaction of Insulin-Like Growth Factors with a Nonfusing Mouse Muscle Cell Line: Binding, Action, and Receptor Down-Regulation*

1984 • 79 citations

The human placenta contains two distinct binding and immunoreactive species of insulin-like growth factor-I receptors.

1985 • 78 citations

Purification and characterization of the receptor for insulin-like growth factor I

1986 • 77 citations

A Novel Fetal Insulin-Like Growth Factor (IGF) I Receptor

1989 • 76 citations

Dual regulation of glycogen metabolism by insulin and insulin-like growth factors in human hepatoma cells (HEP-G2). Analysis with an anti-receptor monoclonal antibody.

1984 • 73 citations

Structure of the insulin-like growth factor receptor in chicken embryo fibroblasts.

1982 • 60 citations

IGF-II binding on human lymphoid cells: Demonstration of a common high affinity receptor for insulin like peptides

1984 • 60 citations

Effects of inhibitors of N-linked oligosaccharide processing on the biosynthesis and function of insulin and insulin-like growth factor-I receptors.

1988 • 58 citations

Separation of the high affinity insulin-like growth factor I receptor from low affinity binding sites by affinity chromatography.

1987 • 58 citations

Similar control mechanisms regulate the insulin and type I insulin-like growth factor receptor kinases. Affinity-purified insulin-like growth factor I receptor kinase is activated by tyrosine phosphorylation of its beta subunit.

1986 • 57 citations

Expression and characterization of a functional human insulin like growth factor-I receptor. J Biol Chem 263:11486-11492

1988 • 57 citations

Insulin-dependent intermolecular subunit communication between isolated alpha beta heterodimeric insulin receptor complexes.

1987 • 57 citations

Insulin promotes the growth of F9 embryonal carcinoma cells apparently by acting through its own receptor

1982 • 55 citations

An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors.

1986 • 54 citations

Purification of insulin-like growth factor I receptor from human placental membranes.

1986 • 51 citations

The structural basis for insulin-like growth factor I receptor high affinity binding.

1988 • 50 citations

Structural and Immunological Characterization of Insulin-Like Growth Factor II Binding to IM-9 Cells*

1986 • 49 citations

Complete glycosylation of the insulin and insulin-like growth factor I receptors is not necessary for their biosynthesis and function. Use of swainsonine as an inhibitor in IM-9 cells.

1986 • 46 citations

Identification of a monoclonal antibody which can distinguish between two distinct species of the type I receptor for insulin-like growth factor

1986 • 45 citations

Insulin and Insulin-Like Growth Factor I Regulate the Same Biological Functions in HEP-G2 Cells Via Their Own Specific Receptors*

1988 • 44 citations

Functional properties of an isolated .alpha..beta. heterodimeric human placenta insulin-like growth factor 1 receptor complex

1988 • 42 citations

Characterization of monoclonal antibodies to the IGF-I receptor that inhibit IGF-I binding to human cells

1985 • 41 citations

Hybrid molecules containing the B-domain of insulin-like growth factor I are recognized by carrier proteins of the growth factor.

1985 • 38 citations

Phosphorylation of insulin-like growth factor I receptor by the insulin receptor tyrosine kinase in intact cultured skeletal muscle cells

1988 • 36 citations

Antibodies to deduced sequences of the insulin receptor distinguish conserved and nonconserved regions in the IGF-I receptor.

1986 • 35 citations

The role of the insulin receptor in mediating the insulin-stimulated growth response in Reuber H-35 cells

1984 • 34 citations

Autophosphorylation within insulin receptor .beta.-subunits can occur as an intramolecular process

1991 • 32 citations

Insulin and nonsuppressible insulin-like activity (NSILA-S) stimulate the same glucose transport system via two separate receptors in rat heart

1977 • 30 citations

Synthesis and characterization of molecular hybrids of insulin and insulin-like growth factor I. The role of the A-chain extension peptide.

1982 • 25 citations

Synthesis of an insulin-like compound consisting of the A chain of insulin and a B chain corresponding to the B domain of human insulin-like growth factor I

1985 • 21 citations

Disulphide reduction alters the immunoreactivity and increases the affinity of insulin-like growth-factor-I receptors in human placenta

1986 • 20 citations

Hybrid molecules containing the A-domain of insulin-like growth factor-I and the B-chain of insulin have increased mitogenic activity relative to insulin

1987 • 19 citations

Growth hormone and insulin-like growth factors I and II produce distinct alterations in glucose metabolism in 3T3-F442A adipocytes.

1985 • 19 citations

Mitogenic Activity and Receptor Reactivity of Hybrid Molecules Containing Portions of the Insulin-like Growth Factor I (IGF-I), IGF-II, and Insulin Molecules

1986 • 18 citations

Structural Determinants of Ligand Recognition by Type I Insulin-Like Growth Factor Receptors: Use of Semisynthetic Insulin Analog Probes*

1988 • 16 citations

Determinants of growth-promoting activity reside in the A-domain of insulin-like growth factor I

1988 • 15 citations

Structural features involved in the biological activity of insulin and the insulin-like growth factors: A27insulinBIGF-I

1985 • 14 citations

Mitogenic activity and receptor reactivity of hybrid molecules containing portions of the insulin-like growth factor I (IGF-I), IGF-II, and insulin molecules

1986 • 3 citations

Deleted Work

1955 • 0 citations