Insulin-dependent intermolecular subunit communication between isolated alpha beta heterodimeric insulin receptor complexes.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.

1982 • 441 citations

Insulin Receptor: Evidence That It Is a Protein Kinase

1983 • 413 citations

The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes.

1980 • 388 citations

Molecular mechanisms of transmembrane signalling

1985 • 352 citations

Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.

1983 • 324 citations

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

1984 • 299 citations

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

1982 • 287 citations

Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation.

1982 • 254 citations

Insulin receptor: covalent labeling and identification of subunits.

1979 • 243 citations

Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system.

1983 • 223 citations

The .beta. subunit of the insulin receptor kinase is an insulin-activated protein

1983 • 219 citations

Photoaffinity labeling of insulin receptor of rat adiopocyte plasma membrane.

1978 • 216 citations

Receptor-mediated phosphorylation of the hepatic insulin receptor: Evidence that the M _r 95,000 receptor subunit is its own kinase

1983 • 213 citations

Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells.

1984 • 208 citations

Molecular basis of insulin action

1986 • 201 citations

Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta.

1984 • 201 citations

Characterization of the insulin receptor kinase purified from human placental membranes.

1983 • 196 citations

Photoaffinity labeling of insulin receptor proteins of liver plasma membrane preparations

1980 • 195 citations

Purification of the insulin receptor from human placenta by chromatography on immobilized wheat germ lectin and receptor antibody.

1980 • 187 citations

The insulin receptor protein kinase. Physicochemical requirements for activity.

1983 • 119 citations

The insulin receptor. Structural basis for high affinity ligand binding.

1987 • 117 citations

Isolation of functional alpha beta heterodimers from the purified human placental alpha 2 beta 2 heterotetrameric insulin receptor complex. A structural basis for insulin binding heterogeneity.

1987 • 99 citations

Insulin Receptors

1983 • 98 citations

Structural requirements for the transmembrane activation of the insulin receptor kinase.

1986 • 93 citations

Intrapeptide autophosphorylation of the epidermal growth factor receptor: regulation of kinase catalytic function by receptor dimerization

1985 • 90 citations

Insulin-like effect of trypsin on the phosphorylation of rat adipocyte insulin receptor.

1983 • 86 citations

Hormone Binding Alters the Conformation of the Insulin Receptor

1980 • 70 citations

Insulin stimulation of the insulin receptor kinase can occur in the complete absence of beta subunit autophosphorylation.

1987 • 40 citations

Incorporation of the purified human placental insulin receptor into phospholipid vesicles

1985 • 37 citations

Subunit structure of the purified human placental insulin receptor. Intramolecular subunit dissociation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

1985 • 37 citations

The nonclassical insulin binding of insulin receptors from rat liver is due to the presence of two interacting α-subunits in the receptor complex

1986 • 32 citations

Urea treatment allows dithiothreitol to release the binding subunit of the insulin receptor from the cell membrane: Implications for the structural organization of the insulin receptor

1985 • 26 citations

Characterization of solubilized insulin receptors from rat liver microsomes. Existence of two receptor species with different binding properties

1986 • 24 citations

Photoreactive Insulin Derivatives: Comparison of Biologic Activity and Labeling Properties of Three Analogues in Isolated Rat Adipocytes

1982 • 24 citations

Dithiothreitol activation of the insulin receptor/kinase does not involve subunit dissociation of the native .alpha.2.beta.2 insulin receptor subunit complex

1986 • 24 citations

The ligand binding subunit of the insulin-like growth factor 1 receptor has properties of a peripheral membrane protein

1986 • 16 citations