Cytokines and inflammatory proteins in alzheimer's disease

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1991 • 2,375 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

1989 • 586 citations

Lipocortin and the mechanism of action of the glucocorticoids

1988 • 499 citations

Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices

1991 • 484 citations

Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related.

1985 • 431 citations

Formation of β-amyloid protein deposits in brains of transgenic mice

1991 • 385 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

Complement activation in amyloid plaques in Alzheimer’s dementia

1988 • 289 citations

Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.

1988 • 254 citations

A4 Protein in Alzheimer's Disease: Primary and Secondary Cellular Events in Extracellular Amyloid Deposition

1989 • 236 citations

Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation.

1987 • 182 citations

Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family

1989 • 174 citations

Nerve growth factor potentiates the neurotoxicity of beta amyloid.

1990 • 171 citations

Amyloidosis: a final common pathway for protein deposition in tissues

1990 • 147 citations

Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA.

1989 • 141 citations

Nerve and epidermal growth factors induce the release of the Alzheimer Amyloid precursor from PC 12 cell cultures

1989 • 133 citations

Amyloidosis: a final common pathway for protein deposition in tissues

1990 • 117 citations

Induction of basic Fibroblast Growth Factor in Alzheimerʼs disease pathology

1990 • 112 citations

Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats

1988 • 111 citations

Regulation of β‐nerve growth factor expression by inflammatory mediators in hippocampal cultures

1990 • 99 citations

Immunoelectron microscopic localization of amyloid β protein in the diffuse plaques of Alzheimer-type dementia

1990 • 69 citations

α₂‐Macroglobulin Synthesis in an Astrocyte Subpopulation

1987 • 62 citations

The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia

1990 • 61 citations

Fibroblast growth factor induces β-amyloid precursor mRNA in glial but not neuronal cultured cells

1990 • 58 citations

Localization of immunoreactive lipocortin-1 in the brain and pituitary gland of the rat. Effects of adrenalectomy, dexamethasone and colchicine treatment

1991 • 47 citations

Macrophages and Astroglial Interactions in Repair to Brain Injurya

1992 • 21 citations

Biological markers of alzheimer's disease

1990 • 21 citations

Potential roles of protease inhibitors in Alzheimer's disease

1989 • 18 citations

Controlling life: Jacques Loeb & the Engineering ideal in Biology

1988 • 11 citations

The Amyloid Gene of Alzheimer’s Disease and Neuronal Dysfunction

1989 • 5 citations