Self-Recognition and the Regulation of Cd4+ T Cell Survival

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Low-Affinity Ligands for the TCR Drive Proliferation of Mature CD8+ T Cells in Lymphopenic Hosts

1999 • 548 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Selective Events in T Cell Development

1994 • 486 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

1999 • 341 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

1994 • 254 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

How αβ T cells deal with induced TCRα ablation

2001 • 224 citations

How Much TCR Does a T Cell Need?

2001 • 224 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules

1998 • 186 citations

Divergent Changes in the Sensitivity of Maturing T Cells to Structurally Related Ligands Underlies Formation of a Useful T Cell Repertoire

1999 • 176 citations

Tetracycline-controllable Selection of CD4+ T Cells: Half-Life and Survival Signals in the Absence of Major Histocompatibility Complex Class II Molecules

2000 • 158 citations

Antiproliferative action of interferon-α requires components of T-cell-receptor signalling

1997 • 157 citations

Survival and Homeostatic Proliferation of Naive Peripheral CD4+ T Cells in the Absence of Self Peptide:MHC Complexes

2000 • 156 citations

CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

2000 • 156 citations

Naïve cytotoxic T lymphocytes spontaneously acquire effector function in lymphocytopenic recipients: A pitfall for T cell memory studies?

1999 • 146 citations

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

1996 • 141 citations

Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors

2001 • 133 citations

Long-Term Survival But Impaired Homeostatic Proliferation of Naïve T Cells in the Absence of p56 ^lck

2000 • 120 citations

Role of the Multiple T Cell Receptor (TCR)-ζ Chain Signaling Motifs in Selection of the T Cell Repertoire

1997 • 116 citations

MHC class I is required for peripheral accumulation of CD8+ thymic emigrants.

1998 • 112 citations

MHC Class I Is Required for Peripheral Accumulation of CD8+ Thymic Emigrants

1998 • 100 citations

Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) zeta subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR zeta.

1993 • 91 citations

Critical Relationship Between TCR Signaling Potential and TCR Affinity During Thymocyte Selection

2000 • 67 citations

TCR-MHC class II interaction is required for peripheral expansion of CD4 cells in a T cell-deficient host

1998 • 56 citations

Mature CD4+ T Cells Perceive a Positively Selecting Class II MHC/Peptide Complex in the Periphery

2000 • 49 citations

The CD4/CD8 lineage decision: integration of signalling pathways

2000 • 45 citations

Differential reactivity of residual CD8⁺ T lymphocytes in TAP1 and β2‐microglobulin mutant mice

1995 • 39 citations

MHC-dependent survival of naïve T cells? A complicated answer to a simple question

2002 • 33 citations

Reactivity and Specificity of CD8⁺ T Cells in Mice with Defects in the MHC Class I Antigen‐Presenting Pathway

1996 • 30 citations

Class II essential for CD4 survival - Response

2001 • 4 citations