Persistent Pulmonary Hypertension of the Newborn

Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn

1997 • 567 citations

Persistent Pulmonary Hypertension of the Newborn in the Era Before Nitric Oxide: Practice Variation and Outcomes

2000 • 558 citations

Nitric oxide for respiratory failure in infants born at or near term

2017 • 513 citations

Distribution and regulation of blood flow in the fetal and neonatal lamb.

1985 • 454 citations

Congenital diaphragmatic hernia in 120 infants treated consecutively with permissive hypercapnea/spontaneous respiration/elective repair

2002 • 421 citations

Management of Infants With Severe Respiratory Failure and Persistence of the Fetal Circulation, Without Hyperventilation

1985 • 361 citations

Inhaled Nitric Oxide for the Early Treatment of Persistent Pulmonary Hypertension of the Term Newborn: A Randomized, Double-Masked, Placebo-Controlled, Dose-Response, Multicenter Study

1998 • 355 citations

Sildenafil Ameliorates Effects of Inhaled Nitric Oxide Withdrawal

1999 • 344 citations

Surfactant Replacement Therapy for Meconium Aspiration Syndrome

1996 • 340 citations

Mechanisms of gas transport during ventilation by high-frequency oscillation

1984 • 335 citations

Congenital diaphragmatic hernia—A tale of two cities: The Boston experience

1997 • 295 citations

Ventilation by high-frequency oscillation

1980 • 266 citations

Pulmonary morbidity in 100 survivors of congenital diaphragmatic hernia monitored in a multidisciplinary clinic

2001 • 245 citations

Extracorporeal membrane oxygenation for severe respiratory failure in newborn infants

2008 • 234 citations

Persistent pulmonary hypertension of the newborn.

1995 • 234 citations

Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn

1995 • 226 citations

Sildenafil Is a Pulmonary Vasodilator in Awake Lambs with Acute Pulmonary Hypertension

2000 • 221 citations

Elevated immunoreactive endothelin-1 levels in newborn infants with persistent pulmonary hypertension

1993 • 220 citations

Outcome at 2 years of infants with congenital diaphragmatic hernia: a population-based study

2003 • 216 citations

Analysis of Nonsteroidal Antiinflammatory Drugs in Meconium and Its Relation to Persistent Pulmonary Hypertension of the Newborn

2001 • 204 citations

Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors

1994 • 182 citations

Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide

2002 • 181 citations

A Review of 100 Patients Transported on Extracorporeal Life Support

2002 • 169 citations

Long-term outcome following extracorporeal membrane oxygenation for congenital diaphragmatic hernia: the UK experience

2004 • 148 citations

Permissive hypercapnia for the prevention of morbidity and mortality in mechanically ventilated newborn infants

2001 • 147 citations

Neurodevelopmental and medical outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide

2002 • 142 citations

Impact of Amicar on hemorrhagic complications of ECMO: a ten-year review

2003 • 142 citations

Decreased Use of Neonatal Extracorporeal Membrane Oxygenation (ECMO): How New Treatment Modalities Have Affected ECMO Utilization

2000 • 136 citations

Nosocomial infections during extracorporeal membrane oxygenation

2001 • 135 citations

Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity

1998 • 133 citations

Survivors of Extracorporeal Membrane Oxygenation at 1 Year of Age: The Relationship of Primary Diagnosis With Health and Neurodevelopmental Sequelae

1995 • 125 citations

Improved pulmonary outcome after exogenous surfactant therapy for respiratory failure in term infants requiring extracorporeal membrane oxygenation

1993 • 124 citations

Pulmonary barotrauma in congenital diaphragmatic hernia: A clinicopathological correlation

1999 • 122 citations

Surfactant (beractant) therapy for infants with congenital diaphragmatic hernia on ECMO: Evidence of persistent surfactant deficiency

1994 • 122 citations

The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide.

1995 • 116 citations

Nitric oxide for respiratory failure in infants born at or near term

2001 • 110 citations

Phosphodiesterase inhibitors for persistent pulmonary hypertension of the newborn: A review

2003 • 102 citations

Inhaled nitric oxide reduces the need for extracorporeal membrane oxygenation in infants with persistent pulmonary hypertension of the newborn

2000 • 102 citations

The Role of Nitric Oxide, Endothelin, and Prostaglandins in the Transition of the Pulmonary Circulation

1995 • 99 citations

Cl- current activation in choroid plexus epithelial cells involves a G protein and protein kinase A

1994 • 87 citations

Neonatal pulmonary hypertension: pathophysiology, classification, and etiology.

1984 • 86 citations

High frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term

2009 • 85 citations

Extracorporeal membrane oxygenation for severe respiratory failure in newborn infants

2002 • 85 citations

Randomized, Controlled Trial of Low-dose Inhaled Nitric Oxide in the Treatment of Term and Near-term Infants With Respiratory Failure and Pulmonary Hypertension

1999 • 84 citations

In Vitro Performance Characteristics of High-Frequency Oscillatory Ventilators

2001 • 84 citations

Aerosolised prostacyclin for pulmonary hypertension in neonates.

1994 • 83 citations

Interaction between Inhaled Nitric Oxide and Intravenous Sildenafil in a Porcine Model of Meconium Aspiration Syndrome

2004 • 79 citations

Neoenatal Pulmonary Hypertension: Pathophysiology Classification and Etiology

1984 • 79 citations

HYPOCAPNIA AND HYPERCAPNIA IN RESPIRATORY MANAGEMENT OF NEWBORN INFANTS

2001 • 78 citations

Venovenous versus venoarterial extracorporeal life support for pediatric respiratory failure: Are there differences in survival and acute complications?

2000 • 77 citations

I-NO/PPHN Study Group. Neurodevelopmental and medical outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide

2002 • 77 citations

Supercarbia in children

1990 • 75 citations

Inhaled nitric oxide reduces the utilization of extracorporeal membrane oxygenation in persistent pulmonary hypertension of the newborn

1997 • 72 citations

PERSISTENT PULMONARY HYPERTENSION OF THE NEWBORN

2001 • 71 citations

Venoarterial versus venovenous extracorporeal membrane oxygenation in congenital diaphragmatic hernia: The extracorporeal life support organization registry, 1990-1999

2001 • 71 citations

Persistent Pulmonary Hypertension of the Newborn: Role of Nitric Oxide and Endothelin in Pathophysiology and Treatment

1995 • 70 citations

Maternal tobacco smoke exposure and persistent pulmonary hypertension of the newborn.

1997 • 69 citations

Clinical approach to inhaled nitric oxide therapy in newborn with hypoxemia

2000 • 69 citations

Pharmacologic therapy of persistent pulmonary hypertension of the newborn

2001 • 68 citations

Haemodynamic features at presentation in persistent pulmonary hypertension of the newborn and outcome.

1996 • 66 citations

Persistent Pulmonary Hypertension of the Newborn

1984 • 65 citations

Respiratory Function in Survivors of the United Kingdom Extracorporeal Membrane Oxygenation Trial

2000 • 62 citations

Controlled prospective randomized comparison of high-frequency jet ventilation and conventional ventilation in neonates with respiratory failure and persistent pulmonary hypertension.

1997 • 61 citations

Neurodevelopmental outcome at 3.5 years of age in children treated with extracorporeal life support: Relationship to primary diagnosis

2000 • 55 citations

Prostacyclin Treatment for Persistent Pulmonary Hypertension of the Newborn

1997 • 55 citations

The development and use of extracorporeal membrane oxygenation in neonates

2003 • 54 citations

Improvement of oxygenation induced by aerosolized prostacyclin in a preterm infant with persistent pulmonary hypertension of the newborn

1997 • 53 citations

Persistence of fetal circulation syndrome: An echocardiographic study

1977 • 52 citations

A 16-Year Neonatal/Pediatric Extracorporeal Membrane Oxygenation Transport Experience

2002 • 52 citations

Venovenous versus venoarterial extracorporeal membrane oxygenation in congenital diaphragmatic hernia

2003 • 51 citations

Venovenous compares favorably with venoarterial access for extracorporeal membrane oxygenation in neonatal respiratory failure

1993 • 49 citations

Complications of neonatal extracorporeal membrane oxygenation

1994 • 47 citations

Inhaled Nitric Oxide in the Treatment of Moderate Persistent Pulmonary Hypertension of the Newborn: A Randomized Controlled, Multicenter Trial

2003 • 47 citations

Immunohistochemical distribution of surfactant apoprotein-A in congenital diaphragmatic hernia

1997 • 46 citations

ECMO IN THE NEWBORN

2000 • 45 citations

Cardiopulmonary outcome of neonatal extracorporeal membrane oxygenation at ages 10–15 years

2003 • 44 citations

Permissive hypercapnia

2002 • 44 citations

Management of a Piglet Model of the Meconium Aspiration Syndrome With High-Frequency or Conventional Ventilation

1992 • 44 citations

Extracorporeal membrane oxygenation for perinatal and pediatric patients.

2003 • 43 citations

Inhaled Nitric Oxide and Gentle Ventilation in the Treatment of Pulmonary Hypertension of the Newborn — a Single-Center, 5-Year Experience

2002 • 43 citations

Neurodevelopmental Outcome in ECMO Vs Near-Miss ECMO Patients at 5 Years of Age

2000 • 43 citations

Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation

1997 • 43 citations

Pulmonary and Systemic Effects of the Phosphodiesterase Inhibitor Dipyridamole in Newborn Lambs with Persistent Pulmonary Hypertension

1998 • 42 citations

Rescue high frequency oscillatory ventilation vs conventional ventilation for infants with severe pulmonary dysfunction born at or near term

2001 • 40 citations

Comparison of venoarterial versus venovenous access in the cerebral circulation of newborns undergoing extracorporeal membrane oxygenation

1999 • 39 citations

Endogenous nitric oxide and endothelin-1 in persistent pulmonary hypertension of the newborn

2001 • 38 citations

Lung volume, dynamic lung compliance, and blood gases during the first 3 days of postnatal life in infants with meconium aspiration syndrome

1982 • 38 citations

Sildenafil (Viagra) in childhood and neonatal pulmonary hypertension

2002 • 37 citations

High-Frequency Oscillatory Ventilation Augments the Response to Inhaled Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn

1998 • 35 citations

Extracorporeal life support – state of the art

2003 • 33 citations

Effect of nitric oxide in meconium aspiration syndrome after treatment with surfactant

1997 • 33 citations

Mandatory admission after isolated mild closed head injury in children: Is it necessary?

2001 • 33 citations

Improved Oxygenation following Adenosine Infusion in Persistent Pulmonary Hypertension of the Newborn

1998 • 32 citations

The current status of neonatal extracorporeal membrane oxygenation

2000 • 32 citations

Percutaneous access for venovenous extracorporeal life support in neonates

1998 • 30 citations

Persistent pulmonary hypertension of newborn due to congenital capillary alveolar dysplasia

2005 • 29 citations

Two years’ follow-up of newborn infants after extracorporeal membrane oxygenation (ECMO)✩

2000 • 29 citations

Do we need new indications for ECMO in neonates pretreated with high-frequency ventilation and/or inhaled nitric oxide?

2000 • 27 citations

Cerebral blood flow during treatment for pulmonary hypertension

1999 • 27 citations

Hypoxic vs Septic Pulmonary Hypertension

1988 • 25 citations

Extracorporeal membrane oxygenation for severe respiratory failure

2002 • 25 citations

Congenital Diaphragmatic Hernia Repair on Extracorporeal Life Support: A Decade of Lessons Learned

2004 • 25 citations

The impact of changing neonatal respiratory management on extracorporeal membrane oxygenation utilization

2002 • 23 citations

Structural Cardiovascular Abnormalities Presenting as Persistent Pulmonary Hypertension of the Newborn

1984 • 23 citations

Innovative neonatal ventilation and meconium aspiration syndrome

2003 • 20 citations

Controversies in the Use of Inhaled Nitric Oxide Therapy in the Newborn

1998 • 20 citations

[Persistent pulmonary hypertension].

1990 • 20 citations

Cardiac transplantation in infants and children

1994 • 20 citations

Hypercalcemia associated with extracorporeal life support in neonates

2001 • 19 citations

Extracorporeal membrane oxygenation causing asymmetric vasculopathy in neonatal infants

1997 • 19 citations

A comparison of clinical variables that predict adverse outcome in term infants with severe respiratory failure randomised to a policy of extracorporeal membrane oxygenation or to conventional neonatal intensive care

2002 • 19 citations

Pulmonary response to group B streptococcal toxin in young lambs

1987 • 18 citations

New Trends in Extracorporeal Membrane Oxygenation in Newborn Pulmonary Diseases

2001 • 16 citations

Noninvasive Assessment of Cardiac Function and Pulmonary Hypertension in Persistent Pulmonary Hypertension of the Newborn

1984 • 15 citations

The use of dipyridamole to wean from inhaled nitric oxide in congenital diaphragmatic hernia

2001 • 15 citations

Nitric oxide in preterm infant with pulmonary hypoplasia

2004 • 15 citations

Survivors of neonatal extracorporeal membrane oxygenation at school age: unusual findings on intelligence testing

1999 • 12 citations

Endothelin-1 levels in infants with pulmonary hypertension receiving extracorporeal membrane oxygenation

1999 • 12 citations

Persistent pulmonary hypertension of the newborn: echocardiographic assessment.

2001 • 12 citations

Determination of gas‐trapping during high frequency oscillatory ventilation

1997 • 12 citations

Hypoplastic left heart syndrome with intact atrial septum: Levoatriocardinal vein stent placement as a bridge to surgery

2002 • 11 citations

Significance of pulmonary venous obstruction in total anomalous pulmonary venous return.

2004 • 9 citations

Type I nitric oxide synthase is decreased in the fetal pulmonary circulation of hypertensive lambs

2002 • 9 citations

Comparison of high-frequency flow interruption ventilation and hyperventilation in persistent pulmonary hypertension of the newborn.

2001 • 9 citations

Comparison of venoarterial versus venovenous access in the cerebral circulation of newborns undergoing extracorporeal membrane oxygenation

2000 • 8 citations

Eisenmenger syndrome in pregnancy: a possible cause of neonatal polycythemia and persistent fetal circulation.

1982 • 8 citations

Secondary Infection Presenting as Recurrent Pulmonary Hypertension

2000 • 7 citations

New Methods Advance Treatment for Respiratory Distress Syndrome

2003 • 7 citations

Venovenous compares favorably with venoarterial access for extracorporeal membrane oxygenation in neonatal respiratory failure

1994 • 6 citations

Meconium aspiration syndrome: current concepts.

1996 • 6 citations

Cor triatriatum masked by primary pulmonary hypertension

1985 • 5 citations

Treatment of persistent pulmonary hypertension of the newborn

2001 • 4 citations

Use of extracorporeal membrane oxygenation to rescue a newborn with early-onset group B streptococcal sepsis and cardiopulmonary failure.

2004 • 4 citations

Thrombosis of the Arterial Cannula During Extracorporeal Membrane Oxygenation in a Full-Term Newborn Infant

1996 • 3 citations

Persistent pulmonary hypertension of the newborn infant. Comparison of conventional versus extracorporeal membrane oxygenation in neonates fulfilling Bartlett's criteria.

1993 • 3 citations

High frequency oscillatory ventilation in newborns with idiopathic persistent pulmonary hypertension.

1995 • 1 citations

Non-hyperventilation respiratory therapy of persistent pulmonary hypertension of the newborn.

1995 • 1 citations

A retrospective study of infants with severe persistent pulmonary hypertension (PPHN) managed without extracorporeal membrane oxygenation (ECMO).

1998 • 1 citations

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