Controversies in the Use of Inhaled Nitric Oxide Therapy in the Newborn

Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

1993 • 1,811 citations

Inhaled nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 865 citations

Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants with Hypoxic Respiratory Failure

1997 • 837 citations

Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn

1997 • 787 citations

Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 731 citations

Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn

1997 • 567 citations

Inhaled Nitric Oxide and Hypoxic Respiratory Failure in Infants With Congenital Diaphragmatic Hernia

1997 • 429 citations

Time‐course and dose‐response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome

1993 • 396 citations

Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide

1993 • 331 citations

Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation: Dose response

1994 • 267 citations

Prospective, randomized comparison of high-frequency oscillation and conventional ventilation in candidates for extracorporeal membrane oxygenation

1994 • 257 citations

Surfactant Treatment of Full-Term Newborns With Respiratory Failure

1991 • 253 citations

Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn

1995 • 226 citations

Role of lung injury in the pathogenesis of hyaline membrane disease in premature baboons

1989 • 224 citations

Acute effects of inhaled nitric oxide in children with severe hypoxemic respiratory failure

1994 • 223 citations

Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb.

1993 • 204 citations

Effects of Inhaled Nitric Oxide on Pulmonary Edema and Lung Neutrophil Accumulation in Severe Experimental Hyaline Membrane Disease

1997 • 181 citations

Ventilator pattern influences neutrophil influx and activation in atelectasis-prone rabbit lung

1994 • 173 citations

Duration and characteristics of treatment of premature lambs with natural surfactant.

1981 • 155 citations

Inhaled nitric oxide for premature infants after prolonged rupture of the membranes

1995 • 146 citations

High-frequency ventilation

1994 • 140 citations

Inhaled Nitric Oxide in the Management of a Premature Newborn With Severe Respiratory Distress and Pulmonary Hypertension

1993 • 138 citations

Hemodynamic effects of exogenous nitric oxide in ovine transitional pulmonary circulation

1992 • 130 citations

Inhaled Nitric Oxide in Congenital Hypoplasia of the Lungs Due to Diaphragmatic Hernia or Oligohydramnios

1994 • 128 citations

Improved pulmonary outcome after exogenous surfactant therapy for respiratory failure in term infants requiring extracorporeal membrane oxygenation

1993 • 124 citations

The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide.

1995 • 116 citations

High-Frequency Oscillatory Ventilation Versus Intermittent Mandatory Ventilation: Early Hemodynamic Effects in the Premature Baboon with Hyaline Membrane Disease

1991 • 108 citations

Disruption of cGMP production in pulmonary arteries isolated from fetal lambs with pulmonary hypertension

1995 • 104 citations

Inhaled Nitric Oxide Improves Gas Exchange and Lowers Pulmonary Vascular Resistance in Severe Experimental Hyaline Membrane Disease

1994 • 101 citations

Bronchoalveolar Inflammatory Pathophysiology of Bronchopulmonary Dysplasia

1995 • 93 citations

Nitric oxide inhalation in infants with respiratory distress syndrome

1997 • 91 citations

Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary vasodilation in the ovine fetus

1995 • 88 citations

Effect of Inhaled Nitric Oxide during Group B Streptococcal Sepsis in Piglets

1993 • 87 citations

Nitric oxide is an antiadhesive molecule for leukocytes.

1995 • 86 citations

Effect of nitric oxide on the survival rate and incidence of lung injury in newborn lambs with persistent pulmonary hypertension

1993 • 80 citations

Ontogeny of NO activity and response to inhaled NO in the developing ovine pulmonary circulation

1994 • 79 citations

Neoenatal Pulmonary Hypertension: Pathophysiology Classification and Etiology

1984 • 79 citations

The Clinical Profile of the Newborn with Persistent Pulmonary Hypertension

1977 • 70 citations

Nitric Oxide Reverses Acute Hypoxic Pulmonary Hypertension in the Newborn Piglet

1994 • 61 citations

Surfactant protein A concentrations in tracheal aspirate fluid from infants requiring extracorporeal membrane oxygenation

1990 • 57 citations

The Effect of Inhaled Nitric Oxide on the Pulmonary Circulation of the Neonatal Pig

1994 • 54 citations

Inhalational Nitric Oxide Therapy for Persistent Pulmonary Hypertension of the Newborn

1993 • 52 citations

Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: The Physiology Matters

1995 • 48 citations

High frequency oscillatory ventilation and extracorporeal membrane oxygenation in severe persistent pulmonary hypertension of the newborn

1992 • 48 citations

The Effects of Nitric Oxide Inhalation on the Pulmonary Circulation of Preterm Lambs

1995 • 47 citations

Inhaled Nitric Oxide Treatment for Stabilization and Emergency Medical Transport of Critically Ill Newborns and Infants

1995 • 46 citations

Non-specificity of surfactant deficiency in neonatal respiratory disorders.

1984 • 45 citations

A DOUBLE MASKED, RANDOMIZED, PLACEBO CONTROLLED, DOSE-RESPONSE STUDY OF INHALED NITRIC OXIDE FOR THE TREATMENT OF PERSISTENT PULMONARY HYPERTENSION OF THE NEWBORN (PPHN). • 851

1997 • 43 citations

A comparison of ventilation strategies for the use of high‐frequency oscillatory ventilation in the treatment of hyaline membrane disease

1989 • 43 citations

Efficacy of Inhalational Nitric Oxide Therapy in the Clinical Management of Persistent Pulmonary Hypertension of the Newborn

1994 • 36 citations

Cerebral hemodynamics and distribution of left ventricular output during inhalation of nitric oxide

1995 • 29 citations

Evidence of surfactant deficiency in persistence of the fetal circulation

1980 • 23 citations

Single Versus Repetitive Doses of Natural Surfactant as Treatment of Respiratory Distress Syndrome in Premature Lambs

1985 • 23 citations

IMPROVED OXYGENATION IN A RANDOMIZED TRIAL OF INHALED NITRIC OXIDE FOR PPHN.• 1498

1996 • 17 citations

ELEVATION OF PULMONARY PDE5-SPECIFIC ACTIVITY IN AN EXPERIMENTAL FETAL OVINE PERINATAL PULMONARY HYPERTENSION MODEL. † 1990

1996 • 16 citations

SURVANTA® PRE-ECMO TRIAL: MULTICENTER EVALUATION OF SURVANTA® IN TREATMENT OF TERM INFANTS WITH SEVERE RESPIRATORY FAILURE. • 1341

1996 • 9 citations

HIGH FREQUENCY OSCILLATORY VENTILATION AUGMENTS THE RESPONSE TO INHALED NITRIC OXIDE IN SEVERE EXPERIMENTAL HYALINE MEMBRANE DISEASE. † 2001

1996 • 5 citations

HEMODYNAMIC EFFECTS OF DIPYRIDAMOLE AND INHALED NITRIC OXIDE IN PATIENTS WITH SEVERE PULMONARY HYPERTENSION. † 228

1996 • 3 citations

Randomized, controlled trial of low dose inhalational nitric oxide in presistent pulmonary hypertension of the newborn (PPHN). • 848

1997 • 2 citations

DIPYRIDAMOLE, A cGMP PHOSPHODIESTERASE INHIBITOR, ATTENUATES REBOUND PULMONARY HYPERTENSION AFTER WITHDRAWAL OF INHALED NITRIC OXIDE IN POSTOPERATIVE CONGENITAL HEART DISEASE. • 163

1996 • 1 citations