Mitochondria, free radicals, neurodegeneration and aging

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Mitochondrial DNA Mutation Associated with Leber's Hereditary Optic Neuropathy

1988 • 2,368 citations

A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies

1990 • 2,006 citations

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

1988 • 1,806 citations

Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNALys mutation

1990 • 1,456 citations

DISEASES OF THE MITOCHONDRIAL DNA

1992 • 1,294 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Mitochondrial DNA Deletions in Progressive External Ophthalmoplegia and Kearns-Sayre Syndrome

1989 • 1,009 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

The oxidative inactivation of mitochondrial electron transport chain components and ATPase.

1990 • 718 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

1991 • 548 citations

Defects in Mitochondrial Protein Synthesis and Respiratory Chain Activity Segregate with the tRNA^Leu(UUR) Mutation Associated with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes

1992 • 426 citations

Leber hereditary optic neuropathy: identification of the same mitochondrial ND1 mutation in six pedigrees.

1991 • 398 citations

Irreversible Inhibition of Mitochondrial Complex I by 1‐Methyl‐4‐Phenylpyridinium: Evidence for Free Radical Involvement

1992 • 371 citations

Defects in mitochondrial protein synthesis and respiratory chain activity segregate with the tRNA(Leu(UUR)) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes.

1992 • 336 citations

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing

1992 • 329 citations

1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles

1990 • 323 citations

Liver mitochondrial respiratory functions decline with age

1989 • 322 citations

Mitochondrial myopathies: Clinical and biochemical features of 30 patients with major deletions of muscle mitochondrial DNA

1989 • 303 citations

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy.

1992 • 298 citations

NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparation

1979 • 293 citations

Evidence for mitochondrial dysfunction in Parkinson's disease-a critical appraisal

1994 • 216 citations

Interaction of 1‐Methyl‐4‐Phenylpyridinium Ion (MPP⁺) and Its Analogs with the Rotenone/Piericidin Binding Site of NADH Dehydrogenase

1991 • 214 citations

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging

1988 • 189 citations

Respiratory Activity of Isolated Rat Brain Mitochondria followingin vitroExposure to Oxygen Radicals

1983 • 181 citations

Maternally inherited duplication of the mitochondrial genome in a syndrome of proximal tubulopathy, diabetes mellitus, and cerebellar ataxia.

1992 • 157 citations

The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages

1993 • 142 citations

Occurrence of a Particular Base Substitution (3243 A to G) in Mitochondrial DNA of Tissues of Ageing Humans

1993 • 134 citations

Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. Functional integrity of mitochondrial DNA from aged subjects.

1994 • 116 citations

A Defect in Mitochondrial Electron-Transport Activity (NADH–Coenzyme Q Oxidoreductase) in Leber's Hereditary Optic Neuropathy

1989 • 114 citations

Myopathy in vitamin E deficient rats: muscle fibre necrosis associated with disturbances of mitochondrial function.

1993 • 95 citations

Quantitation of a mitochondrial DNA deletion in Parkinson's disease

1992 • 87 citations

Alteration of inner-membrane components and damage to electron-transfer activities of bovine heart submitochondrial particles induced by NADPH-dependent lipid peroxidation

1982 • 85 citations

Mitochondrial Disorders in Neurology

1994 • 79 citations

Platelet mitochondrial function in Leber's hereditary optic neuropathy

1994 • 76 citations

Iron induced oxidative stress and mitochondrial dysfunction: relevance to Parkinson's disease

1993 • 75 citations

A tandem duplication in the D–loop of human mitochondrial DNA is associated with deletions in mitochondrial myopathies

1993 • 73 citations

Sequential damage in mitochondrial complexes by peroxidative stress

1991 • 57 citations

Nucleus‐driven mutations of human mitochondrial DNA

1992 • 57 citations

Relationship of Dihydropyridine Binding Sites with Calcium‐Dependent Neurotransmitter Release in Synaptosomes

1988 • 37 citations

Mitochondrial Disorders in Neurology

1994 • 35 citations

Deleted Work

1955 • 0 citations