Activity and interleukin 1 responsiveness of SV40 enhancer motifs in a rodent immature T cell line.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

Fos-Associated Protein p39 Is the Product of the jun Proto-Oncogene

1988 • 643 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

A High-Efficiency HeLa Cell Nuclear Transcription Extract

1988 • 612 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

Activation of HIV gene expression during monocyte differentiation by induction of NF-kB

1989 • 590 citations

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1984 • 529 citations

Multiple sequence motifs are involved in SV40 enhancer function.

1986 • 511 citations

fos-associated cellular p39 is related to nuclear transcription factor AP-1

1988 • 508 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter.

1988 • 308 citations

Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA Motif

1988 • 304 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

1989 • 271 citations

Two high-affinity interleukin 1 receptors represent separate gene products.

1989 • 268 citations

The SV40 enhancer can be dissected into multiple segments, each with a different cell type specificity.

1987 • 265 citations

The role of the κ enhancer and its binding factor NF-κB in the developmental regulation of κ gene transcription

1987 • 247 citations

Binding of a nuclear factor to a regulatory sequence in the promoter of the mouse H-2Kb class I major histocompatibility gene.

1987 • 244 citations

Discrete elements within the SV40 enhancer region display different cell-specific enhancer activities.

1987 • 240 citations

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

1988 • 238 citations

Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes.

1989 • 230 citations

Cell-type specific protein binding to the enhancer of simian virus 40 in nuclear extracts

1986 • 209 citations

Functionally Distinct NF-κB Binding Sites in the Immunoglobulin κ and IL-2 Receptor α Chain Genes

1989 • 194 citations

The interleukin 1 receptor. Dynamics of interleukin 1 binding and internalization in T cells and fibroblasts.

1987 • 190 citations

Evidence for different interleukin 1 receptors in murine B- and T-cell lines.

1989 • 186 citations

Purification of KBF1, a common factor binding to both H-2 and beta 2-microglobulin enhancers.

1987 • 184 citations

Cyclic AMP--an intracellular second messenger for interleukin 1.

1988 • 182 citations

Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein.

1989 • 176 citations

Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism.

1987 • 157 citations

Binding, internalization, and intracellular localization of interleukin-1 beta in human diploid fibroblasts.

1988 • 156 citations

NF-kappa B protein purification from bovine spleen: nucleotide stimulation and binding site specificity.

1988 • 148 citations

Human thymic epithelial cells produce interleukin 1.

1987 • 136 citations

Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer

1989 • 135 citations

Interleukin 1-dependent induction of both interleukin 2 secretion and interleukin 2 receptor expression by thymoma cells.

1986 • 133 citations

Interleukin-1 generates transmembrane signals from phospholipids through novel pathways in cultured rat mesangial cells.

1989 • 128 citations

One cell-specific and three ubiquitous nuclear proteins bind in vitro to overlapping motifs in the domain B1 of the SV40 enhancer.

1987 • 127 citations

A biochemical and kinetic analysis of the interleukin-1 receptor. Evidence for differences in molecular properties of IL-1 receptors.

1987 • 123 citations

A purine-rich DNA sequence motif present in SV40 and lymphotropic papovavirus binds a lymphoid-specific factor and contributes to enhancer activity in lymphoid cells.

1987 • 110 citations

Binding of a Nuclear Factor to a Regulatory Sequence in the Promoter of the Mouse H-2K^b Class I Major Histocompatibility Gene

1987 • 101 citations

Cell-specific activity of the constituent elements of the simian virus 40 enhancer.

1987 • 86 citations

Hybrids between rat lymphoma and mouse T cells with inducible cytolytic activity

1982 • 81 citations

Identification and purification of EBP1: a HeLa cell protein that binds to a region overlapping the 'core' of the SV40 enhancer.

1988 • 63 citations

The SV40 TC-II(kappa B) and the related H-2Kb enhansons exhibit different cell type specific and inducible proto-enhancer activities, but the SV40 core sequence and the AP-2 binding site have no enhanson properties.

1989 • 63 citations

The SV40 TC-II(kappa B) enhanson binds ubiquitous and cell type specifically inducible nuclear proteins from lymphoid and non-lymphoid cell lines.

1989 • 61 citations

Heterogeneity of immature (Lyt-2-/L3T4-) thymocytes. Identification of four major phenotypically distinct subsets differing in cell cycle status and in vitro activation requirements.

1988 • 57 citations

Interleukin 1 and Cyclic AMP Induce κ Immunoglobulin Light-Chain Expression via Activation of an NF-κB-Like DNA-Binding Protein

1989 • 57 citations

Characterization of soluble factors that induce the cytolytic activity and the expression of T cell growth factor receptors of a T cell hybrid.

1984 • 54 citations

Induction of c-fos and c-myc expression in T lymphocytes after treatment with recombinant interleukin 1-alpha.

1986 • 45 citations

Recombinant tumor necrosis factor can induce interleukin 2 receptor expression and cytolytic activity in a rat × mouse T cell hybrid

1987 • 40 citations

Rat × Mouse T‐cell Hybrids with Inducible Specific Cytolytic Activity

1983 • 39 citations

Interleukin 1 modulates messenger RNA levels of lymphokines and of other molecules associated with T cell activation in the T cell lymphoma LBRM33-1A5.

1987 • 36 citations

Signal requirement for interleukin-1-dependent interleukin 2 production by a human leukemia-derived HSB.2 subclone.

1987 • 28 citations

Interleukin 1 and tumor necrosis factor enhance transcription from the SV40 early promoter in a T cell line

1989 • 11 citations