Gene expression and genetic engineering in the lens. Friedenwald lecture.

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

SV40-transformed simian cells support the replication of early SV40 mutants

1981 • 2,564 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin.

1982 • 792 citations

Lens Differentiation in Vertebrates

1981 • 638 citations

Transgenic mice harboring SV40 t-antigen genes develop characteristic brain tumors

1984 • 492 citations

Erythroid-specific expression of human beta-globin genes in transgenic mice.

1985 • 436 citations

Constitutive and Conditional Suppression of Exogenous and Endogenous Genes by Anti-Sense RNA

1985 • 343 citations

An Improved Technique for Obtaining Enhanced Infectivity with Herpes Simplex Virus Type 1 DNA

1976 • 304 citations

Molecular Aspects of Lens Cell Differentiation

1967 • 300 citations

X-ray analysis of the eye lens protein γ-II crystallin at 1·9 Å resolution

1983 • 297 citations

An inherited limb deformity created by insertional mutagenesis in a transgenic mouse

1985 • 294 citations

Do genes-in-pieces imply proteins-in-pieces?

1978 • 287 citations

Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death

1984 • 285 citations

Alternative RNA splicing of the murine αA-crystallin gene: Protein-coding information within an intron

1983 • 251 citations

A foreign β-globin gene in transgenic mice: Integration at abnormal chromosomal positions and expression in inappropriate tissues

1983 • 245 citations

Specific expression of an elastase–human growth hormone fusion gene in pancreatic acinar cells of transgenic mice

1985 • 243 citations

Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.

1985 • 242 citations

SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic mice

1985 • 241 citations

Specific expression of a foreign β-globin gene in erythroid cells of transgenic mice

1985 • 235 citations

Rescue of the Drosophila Phototransduction Mutation trp by Germline Transformation

1985 • 230 citations

Developmental regulation of a cloned adult β-globin gene in transgenic mice

1985 • 215 citations

The Application of Bone Marrow Transplantation to the Treatment of Genetic Diseases

1986 • 207 citations

An embryonic pattern of expression of a human fetal globin gene in transgenic mice

1986 • 204 citations

Domain structure and evolution in α‐crystallins and small heat‐shock proteins

1985 • 180 citations

Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line

1983 • 161 citations

Tissue-Specific Expression in Transgenic Mice of a Fused Gene Containing RSV Terminal Sequences

1986 • 154 citations

Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice

1985 • 150 citations

Regulated gene expression in transfected primary chicken erythrocytes.

1986 • 144 citations

Lens crystallins and their gene families

1984 • 142 citations

Cell division, cell elongation and the co-ordination of crystallin gene expression during lens morphogenesis in the rat

1978 • 133 citations

Lens-specific expression of the chloramphenicol acetyltransferase gene promoted by 5' flanking sequences of the murine alpha A-crystallin gene in explanted chicken lens epithelia.

1985 • 132 citations

Complete structure of the alpha B-crystallin gene: conservation of the exon-intron distribution in the two nonlinked alpha-crystallin genes.

1985 • 130 citations

Myxococcus xanthus spore coat protein S may have a similar structure to vertebrate lens βγ-crystallins

1985 • 125 citations

Gene and protein structure of a β-crystallin polypeptide in murine lens: relationship of exons and structural motifs

1983 • 121 citations

Retrovirus insertion inactivates mouse α 1(I) collagen gene by blocking initiation of transcription

1986 • 118 citations

Eye‐lens proteins: The three‐dimensional structure of β‐crystallin predicted from monomeric γ‐crystallin

1981 • 112 citations

Chapter 5 Problems of Differentiation in the Vertebrate Lens

1970 • 103 citations

Regulation of protein synthesis, intracellular electrolytes and cataract formation in vitro

1977 • 103 citations

Delta crystallins and their nucleic acids

1984 • 101 citations

Structural and Evolutionary Relationships Among Five Members of the Human γ-Crystallin Gene Family

1985 • 90 citations

Philly mouse: A new model of hereditary cataract

1980 • 89 citations

αA-Crystallin Messenger RNA of the Mouse Lens: More Noncoding Than Coding Sequences

1982 • 78 citations

δ- and β-crystallin mRNA levels in the embryonic and posthatched chicken lens: Temporal and spatial changes during development

1985 • 76 citations

A novel type of crystallin in the frog eye lens

1984 • 75 citations

Changes in chick lens proteins with aging

1968 • 74 citations

Loss during development of the ability of chick embryonic lens cells to elongate in culture: Inverse relationship between cell division and elongation

1972 • 73 citations

Lens-specific antigens and cytodifferentiation in the developing lens

1968 • 69 citations

Aging of protein molecules: lens crystallins as a model system

1981 • 69 citations

Subunits of Alpha-Crystallin from Adult and Embryonic Cattle Lens

1968 • 67 citations

LENS CELL ELONGATION IN VITRO AND MICROTUBULES

1975 • 65 citations

Isolation and In Vitro Translation of δ-Crystallin mRNA from Embryonic Chick Lens Fibers

1974 • 62 citations

Lens Fiber Differentiation and Gamma Crystallins: Immunofluorescent Study of Wolffian Regeneration

1965 • 62 citations

Molecular cloning and partial characterization of delta-crystallin cDNA sequences in a bacterial plasmid.

1979 • 60 citations

Crystallin synthesis by Chick Lens

1971 • 60 citations

Resolution of two distinct embryonic chick δ-crystallin bands by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and urea

1977 • 58 citations

Relationship between crystallin mRNA expression in retina cells and their capacity to re-differentiate into lens cells

1979 • 56 citations

The appearance of α-crystallin in relation to cell cycle phase in the embryonic mouse lens

1983 • 54 citations

Multiple gamma-crystallins of the mouse lens: fractionation of mRNAs by cDNA cloning.

1982 • 53 citations

Evolution and diversity of the crystallins. Nucleotide sequence of a beta-crystallin mRNA from the mouse lens.

1982 • 52 citations

Organization of δ-crystallin genes in the chicken

1982 • 49 citations

Tissue-specific regulation of a chicken delta-crystallin gene in mouse cells: involvement of the 5′ end region.

1985 • 47 citations

cDNA and deduced protein sequence for the beta B1-crystallin polypeptide of the chicken lens. Conservation of the PAPA sequence.

1986 • 45 citations

DNA sequences responsible for tissue-specific expression of a chicken alpha-crystallin gene in mouse lens cells.

1985 • 45 citations

Intracellular ions, protein metabolism, and cataract formation.

1980 • 42 citations

Interaction of Crystallins with the Cytoskeletal–Plasma Membrane Complex of the Bovine Lens

1984 • 42 citations

Thioacetamide-induced cataract with invasive proliferation of the lens epithelium in rainbow trout.

1966 • 41 citations

Cytoplasmic RNA sequences complementary to cloned chick δ-crystallin cDNA show size heterogeneity.

1982 • 41 citations

β-crystallin mRNAs: Differential distribution in the developing chicken lens

1981 • 40 citations

An Immuno-embryological Study on the Chick Lens

1961 • 40 citations

The chicken delta-crystallin gene family. Two genes of similar structure in close chromosomal approximation.

1984 • 40 citations

Isolation and cell-free translation of chick lens crystallin mRNA during normal development and transdifferentiation of neural retina

1978 • 38 citations

Differentiation-dependent expression of the chicken delta-crystallin gene introduced into mouse teratocarcinoma stem cells.

1984 • 36 citations

Chicken lens δ-crystallin gene expression and methylation in several non-lens tissues

1983 • 36 citations

Cloning and characterization of a cow beta crystallin cDNA

1984 • 36 citations

Eye Lens Proteins and Vertebrate Phylogeny

1982 • 36 citations

THE SOLUBLE PROTEINS OF THE LENS.

1965 • 32 citations

Evidence against γ-crystallin DNA or RNA sequences in the chicken

1984 • 31 citations

The pattern of expression of chick delta-crystallin genes in lens differentiation and in trans-differentiating cultured tissues.

1983 • 30 citations

Diversity of beta-crystallin mRNAs of the chicken lens. Hybridization analysis with cDNA clones.

1983 • 30 citations

Studies on biosynthesis of soluble lens crystallin antigens in the chick by isoelectric focusing in thin-layer polyacrylamide gel

1976 • 30 citations

Lens Soluble Proteins: Correlation with the Cytological Differentiation in the Young Adult Organ of the Chick

1968 • 28 citations

Failure of growth regulation of the lens epithelium in strains of fast-growing chicks

1975 • 27 citations

Electrophoretic studies on the heterogeneity of the chicken lens crystallins

1968 • 26 citations

Isoelectric focusing and immunochemistry of lens crystallins

1974 • 24 citations

Isolation and Characterization of Rat‐Lens Messenger RNAs

1976 • 22 citations

LENS PROTEINS DURING EMBRYONIC DEVELOPMENT OF DIFFERENT VERTEBRATES.

1965 • 22 citations

Two Structurally Closely Related Polypeptides Encoded by 14-S mRNA Isolated from Rat Lens

1978 • 21 citations

Molecular Structure and Antigenicity of Lens Proteins

1967 • 21 citations

Abnormalities in the differentiation and cellular properties of hyperplastic lens epithelium from strains of chickens selected for high growth rate

1976 • 20 citations

Promoter Sequences of Murine A Crystallin, Murine 2(I) Collagen or of Avian Sarcoma Virus Genes Linked to the Bacterial Chloramphenicol Acetyl Transferase Gene Direct Tissue-specific Patterns of Chloramphenicol Acetyl Transferase Expression in Transgenic Mice

1985 • 18 citations

Gene modification: Targeting in mammalian cells

1985 • 16 citations

Anion and cation effects on δ-crystallin synthesis in the cultured embryonic chick lens and in a reticulocyte lysate

1980 • 16 citations

A lamprey lens protein related to avian and reptilian 5 crystallin

1984 • 15 citations

Analysis of Mammalian Lens Proteins by Electrophoresis

1964 • 13 citations

Two tryptic peptide differences among the subunits of δ-crystallin of the embryonic chick lens

1980 • 13 citations

Protein synthesis in organ cultured chick lens

1982 • 12 citations

Gene Therapy—So Near and Yet So Far Away

1986 • 10 citations

Partial sequence homology of human myc oncogene protein to beta and gamma crystallins

1985 • 9 citations

Ultrastructural and biochemical abnormalities of lens cell membranes from two strains of chicks with epithelial hyperplasia

1979 • 9 citations

Crystallin Genes: Templates for Lens Transparency

1984 • 8 citations