Loss of Tumorigenicity and Increased Immunogenicity Induced by Interleukin-10 Gene Transfer in B16 Melanoma Cells

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Interleukin-10

1993 • 1,820 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

1993 • 821 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4

1992 • 540 citations

IL-10: a novel cytotoxic T cell differentiation factor.

1991 • 391 citations

Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression.

1994 • 314 citations

Experimental and Clinical Studies of Cytokine Gene-Modified Tumor Cells

1994 • 259 citations

Production of IL‐10 by melanoma cells: Examination of its role in immunosuppression mediated by melanoma

1994 • 248 citations

Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now?

1994 • 245 citations

Interleukin‐10 production by human carcinoma cell lines and its relationship to interleukin‐6 expression

1993 • 245 citations

Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.

1992 • 235 citations

Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells.

1992 • 232 citations

Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma.

1993 • 221 citations

Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma.

1992 • 205 citations

Local expression of antiinflammatory cytokines in cancer.

1993 • 198 citations

Human IL-10 is a chemoattractant for CD8+ T lymphocytes and an inhibitor of IL-8-induced CD4+ T lymphocyte migration.

1993 • 184 citations

Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans.

1993 • 183 citations

Lymphoid Cell Surface Interaction Structures Detected Using Cytolysis‐Inhibiting Monoclonal Antibodies

1982 • 155 citations

Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.

1993 • 140 citations

T Cell Recognition of Human Tumors: Implications for Molecular Immunotherapy of Cancer

1993 • 137 citations

Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers

1992 • 124 citations

Production of interleukin-10 by human bronchogenic carcinoma.

1994 • 119 citations

Tumor-infiltrating lymphocytes: their phenotype, functions and clinical use

1994 • 92 citations

Recognition of major histocompatibility complex class I antigens by natural killer cells.

1994 • 84 citations

In vivo and in vitro characteristics of interleukin 6-transfected B16 melanoma cells.

1992 • 71 citations

The role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma. I. Induction of regulatory macrophages in normal mice by the in vivo administration of rGM-CSF.

1991 • 65 citations

Interleukin-10 is a potent inhibitor of tumor cytotoxicity by human monocytes and alveolar macrophages

1994 • 63 citations

Retroviruses expressing different levels of the normal epidermal growth factor receptor: Biological properties and new bioassay

1989 • 57 citations

Tumor necrosis factor expression by human ovarian carcinoma in vivo.

1991 • 56 citations

Action of natural killer cells and macrophages in cancer

1993 • 44 citations

Cytokine gene expression in primary brain tumours, metastases and meningiomas suggests specific transcription patterns

1993 • 43 citations

On the Relative Roles of Interleukin-2 and Interleukin-10 in the Generation of Lymphokine-Activated Killer Cell Activity

1993 • 40 citations

Cytokine gene transcription in renal cell carcinoma

1993 • 30 citations

Non-antibody immunotherapy of cancer

1993 • 26 citations

EFFECTS OF SYSTEMIC ADMINISTRATION OF rIL-10 IN AN IN VIVO MODEL OF ALLOREACTIVITY

1994 • 20 citations

Cancer escape from immune surveillance: How can it be overcome by gene transfer?

1994 • 15 citations

Suppression of the Delayed Type Hypersensitivity Response by Tumor Facilitating Factor of B16 Melanoma

1993 • 2 citations