Cellular redox state and its relationship to the inhibition of clonal cell growth and the induction of apoptosis during all-trans retinoic acid exposure in acute myeloblastic leukemia cells.

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.

1980 • 1,997 citations

Annexin V-Affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure

1998 • 1,850 citations

Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells

1980 • 1,094 citations

A New Method for the Cytofluorometric Analysis of Mitochondrial Membrane Potential Using the J-Aggregate Forming Lipophilic Cation 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine Iodide (JC-1)

1993 • 1,015 citations

JC‐1, but not DiOC₆(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis

1997 • 982 citations

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

1992 • 912 citations

Glutathione-Associated Enzymes In Anticancer Drug Resistance

2016 • 864 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

1982 • 704 citations

Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1

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Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid

1981 • 566 citations

Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice

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A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients

1991 • 412 citations

All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship

1990 • 390 citations

Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin‐1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation

1993 • 351 citations

The role of intracellular oxidants in apoptosis

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Retinoic acid. Inhibition of the clonal growth of human myeloid leukemia cells.

1982 • 224 citations

Relationship of cellular glutathione to the cytotoxicity and resistance of seven platinum compounds.

1992 • 215 citations

Redox regulation of manganese superoxide dismutase

1996 • 180 citations

Retinoic acid enhances colony-stimulating factor-induced clonal growth of normal human myeloid progenitor cells in vitro*1

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Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines.

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Protective roles of cytokines against radiation: Induction of mitochondrial MnSOD

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The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer

1998 • 150 citations

Role of antioxidants and intracellular free radicals in retinamide- induced cell death

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Overexpression of manganese-containing superoxide dismutase confers resistance to the cytotoxicity of tumor necrosis factor alpha and/or hyperthermia.

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Expression of a retinoic acid receptor gene in myeloid leukemia cells.

1989 • 107 citations

Transfection of complementary DNAs for the heavy and light subunits of human gamma-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan.

1995 • 97 citations

Manganese Superoxide Dismutase in Healthy Human Pleural Mesothelium and in Malignant Pleural Mesothelioma

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Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation.

1985 • 76 citations

Increase in gamma-glutamylcysteine synthetase activity and steady-state messenger RNA levels in melphalan-resistant DU-145 human prostate carcinoma cells expressing elevated glutathione levels.

1992 • 75 citations

Tumor necrosis factor-alpha increases Mn-SOD expression: protection against oxidant injury

1991 • 73 citations

How Does Superoxide Dismutase Protect Against Tumor Necrosis Factor: A Hypothesis Informed by Effect of Superoxide on “FREE” Iron

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Regulation of manganese superoxide dismutase and other antioxidant genes in normal and leukemic hematopoietic cells and their relationship to cytotoxicity by tumor necrosis factor

1993 • 63 citations

Ethanol Causes Accelerated G1 Arrest in Differentiating HL‐60 Cells

1990 • 62 citations

Role of retinoic acid and oxidative stress in embryonic stem cell death and neuronal differentiation

1996 • 61 citations

all-trans retinoic acid enhances cisplatin-induced apoptosis in human ovarian adenocarcinoma and in squamous head and neck cancer cells.

1997 • 53 citations

Evidence for cell cycle phase-specific initiation of a program of HL-60 cell myeloid differentiation mediated by inducer uptake.

1984 • 52 citations

Assay of γ-glutamylcysteine synthetase and glutathione synthetase in erythrocytes by high-performance liquid chromatography with fluorimetric detection

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An Oxidative Stress-Mediated Death Pathway in Irradiated Human Leukemia Cells Mapped Using Multilaser Flow Cytometry

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Anticancer Quinones Induce pRb-Preventable G2/M Cell Cycle Arrest and Apoptosis

1998 • 48 citations

Mitochondrial superoxide dismutase induction does not protect epithelial cells during oxidant exposure in vitro

1995 • 42 citations

Co-ordinated over-expression of the MRP and γ-glutamylcysteine synthetase genes, but not MRD1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines

1998 • 38 citations

OCI/AML-4 an acute myeloblastic leukemia cell line: regulation and response to cytosine arabinoside.

1991 • 33 citations

An association between mitochondrial function and all‐trans retinoic acid‐induced apoptosis in acute myeloblastic leukaemia cells

1999 • 31 citations

Mn and Cu/Zn SOD expression in cells from LPS-sensitive and LPS-resistant mice☆

1992 • 29 citations

Role of intracellular redox status in apoptosis induction of human T-cell leukemia virus type I-infected lymphocytes by 13-cis-retinoic acid.

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p53 status of newly established acute myeloid leukaemia cell lines

1999 • 27 citations

Modulation of Glutathione and Related Enzymes in Reversal of Resistance to Anticancer Drugs

1995 • 26 citations

Comparison of the effects of all-trans and cis-retinoic acid on the blast stem cells of acute myeloblastic leukemia in culture.

1992 • 20 citations

Induction of p53 by the Concerted Actions of Aziridine and Quinone Moieties of Diaziquone

1998 • 20 citations

All-trans retinoic acid induces apoptosis in acute myeloblastic leukaemia cells

1997 • 14 citations

Retinoids and apoptosis in cancer therapy

1996 • 9 citations

Oxyradicals as Signal Transducers

1997 • 9 citations

The effect of doxorubicin on the glutathione content and viability of cultured human lung cancer cell lines A549 and GLC4210

1990 • 5 citations

ALL-TRANS RETINOIC ACID- INDUCED APOPTOSIS IN ACUTE MYELOBLASTIC LEUKEMIA CELLS

2000 • 3 citations