An association between mitochondrial function and all‐trans retinoic acid‐induced apoptosis in acute myeloblastic leukaemia cells

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 • 3,106 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.

1980 • 1,997 citations

Annexin V-Affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure

1998 • 1,850 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

A New Method for the Cytofluorometric Analysis of Mitochondrial Membrane Potential Using the J-Aggregate Forming Lipophilic Cation 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine Iodide (JC-1)

1993 • 1,015 citations

JC‐1, but not DiOC₆(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis

1997 • 982 citations

Mitochondria and apoptosis

1998 • 892 citations

Cytochrome c: Can't Live with It—Can't Live without It

1997 • 768 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.

1995 • 598 citations

Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid

1981 • 566 citations

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

1998 • 414 citations

A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients

1991 • 412 citations

Low molecular weight heparins: prophylaxis of venous thromboembolism in surgical patients.

1997 • 399 citations

All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship

1990 • 390 citations

Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

1997 • 348 citations

Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40.

1994 • 320 citations

bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells

1992 • 276 citations

Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis

1996 • 225 citations

Retinoic acid. Inhibition of the clonal growth of human myeloid leukemia cells.

1982 • 224 citations

Induction of the Mitochondrial Permeability Transition Causes Release of the Apoptogenic Factor Cytochrome c

1998 • 216 citations

Cytochrome c-dependent and -independent Induction of Apoptosis in Multiple Myeloma Cells

1997 • 200 citations

Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition

1997 • 179 citations

The relationship between bcl‐2 expression and response to chemotherapy in acute leukaemia

1994 • 165 citations

Effects of BCL-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells

1994 • 162 citations

High bcl-2 expression in acute myeloid leukemia cells correlates with CD34 positivity and complete remission rate

1997 • 138 citations

Bcl2 inhibits apoptosis associated with terminal differentiation of HL- 60 myeloid leukemia cells

1994 • 136 citations

Phosphatidylserine Externalization Is a Downstream Event of Interleukin-1β–Converting Enzyme Family Protease Activation During Apoptosis

1997 • 127 citations

Annexin-V and TUNEL use in monitoring the progression of apoptosis in plants.

1997 • 126 citations

Inhibition of bcl-2 with antisense oligonucleotides induces apoptosis and increases the sensitivity of AML blasts to Ara-C.

1995 • 122 citations

Apoptosis in the Absence of Cytochrome c Accumulation in the Cytosol

1998 • 119 citations

Annexin-V and TUNEL use in monitoring the progression of apoptosis in plants

1997 • 112 citations

Measurement of Spontaneous and Therapeutic Agent-Induced Apoptosis With BCL-2 Protein Expression in Acute Myeloid Leukemia

1997 • 112 citations

Expression of a retinoic acid receptor gene in myeloid leukemia cells.

1989 • 107 citations

Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells.

1995 • 99 citations

Bcl-2 inhibits retinoic acid-induced apoptosis during the neural differentiation of embryonal stem cells.

1996 • 97 citations

All-trans retinoic acid (ATRA)-induced apoptosis is preceded by G1 arrest in human MCF-7 breast cancer cells

1998 • 92 citations

Modulation of Idarubicin-Induced Apoptosis in Human Acute Myeloid Leukemia Blasts by All-Trans Retinoic Acid, 1,25(OH)2 Vitamin D3, and Granulocyte-Macrophage Colony-Stimulating Factor

1997 • 73 citations

Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the Ara-C sensitivity of leukemic stem cells.

1995 • 71 citations

Control of sensitivity to induction of apoptosis in myeloid leukemic cells by differentiation and bcl-2 dependent and independent pathways.

1994 • 53 citations

Down‐regulation of bcl‐2 in AML blasts by all‐trans retinoic acid and its relationship to CD34 antigen expression

1996 • 52 citations

Comparative quantitative expression of bcl‐2 by normal and leukaemic myeloid cells

1995 • 46 citations

Five putative drug resistance parameters (MDR1/P‐glycoprotein, MDR‐associated protein, glutathione‐S‐transferase, bcl‐2 and topoisomerase IIα) in 57 newly diagnosed acute myeloid leukaemias

1997 • 29 citations

Role of intracellular redox status in apoptosis induction of human T-cell leukemia virus type I-infected lymphocytes by 13-cis-retinoic acid.

1997 • 29 citations

In vitro down-regulation of bcl-2 expression by all-trans retinoic acid in AML blasts

1997 • 28 citations

p53 status of newly established acute myeloid leukaemia cell lines

1999 • 27 citations

Comparison of the effects of all-trans and cis-retinoic acid on the blast stem cells of acute myeloblastic leukemia in culture.

1992 • 20 citations

All-trans retinoic acid induces apoptosis in acute myeloblastic leukaemia cells

1997 • 14 citations

ALL-TRANS RETINOIC ACID- INDUCED APOPTOSIS IN ACUTE MYELOBLASTIC LEUKEMIA CELLS

2000 • 3 citations