Induction of p53 by the Concerted Actions of Aziridine and Quinone Moieties of Diaziquone

p53 Mutations in Human Cancers

1991 • 8,133 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Hydrogen peroxide production during experimental protein glycation

1990 • 497 citations

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

1995 • 491 citations

Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.

1996 • 382 citations

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.

1994 • 377 citations

Molecular Actions and Targets for Cancer Chemotherapeutic Agents

1981 • 361 citations

Biochemical analysis of membranes

1977 • 351 citations

Genetic basis for p53 overexpression in human breast cancer.

1991 • 287 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

Metabolism and reactions of quinoid anticancer agents

1987 • 273 citations

Mutations in p53 as potential molecular markers for human breast cancer.

1991 • 222 citations

The Basic Science of Oncology

1987 • 212 citations

Radiation Chemistry of Organic Compounds

1961 • 211 citations

Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response.

1995 • 203 citations

Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents.

1993 • 201 citations

p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin.

1995 • 167 citations

Adenovirus-mediated wild-type p53 expression induces apoptosis and suppresses tumorigenesis of prostatic tumor cells.

1995 • 137 citations

DNA strand scission and free radical production in menadione-treated cells. Correlation with cytotoxicity and role of NADPH quinone acceptor oxidoreductase.

1992 • 136 citations

Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 128 citations

P53 Gene Mutations in Lymphoid Diseases and Their Possible Relevance to Drug Resistance

1995 • 90 citations

p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: suppression by E1B 19K and Bcl-2 proteins.

1995 • 86 citations

Regulation of p53 protein expression in human breast cancer cell lines

1993 • 85 citations

Induction of apoptosis by tumor suppressor genes and oncogenes

1995 • 81 citations

The tumor suppressor protein p53

1995 • 74 citations

Normal p53 status and function despite the development of drug resistance in human breast cancer cells.

1995 • 72 citations

Kinetics of anthracycline antibiotic free radical formation and reductive glycosidase activity

1983 • 67 citations

Increased sequence-specific p53-DNA binding activity after DNA damage is attenuated by phorbol esters.

1993 • 54 citations

Ionizing radiation induces apoptotic cell death in human TcR‐γ/δ⁺ T and natural killer cells without detectable p53 protein

1994 • 42 citations

Protein synthesis—dependent cytoplasmic translocation of p53 protein after serum stimulation of growth‐arrested MCF‐7 cells

1993 • 39 citations

The emerging picture of p53

1994 • 37 citations

Mechanism for the Reductive Activation of Diaziquone

1985 • 35 citations

The reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells: Free radical formation and NAD(P)H: Quinone-acceptor oxidoreductase (DT-diaphorase) activity

1991 • 30 citations

Reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells

1992 • 25 citations