Receptors for fibroblast growth factors

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Proteoglycans: Structures And Interactions

1991 • 1,596 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

1994 • 1,273 citations

Structural and Functional Diversity in the FGf Receptor Multigene Family

1992 • 1,262 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

1992 • 1,095 citations

Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome

1995 • 908 citations

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

1994 • 903 citations

Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome

1994 • 759 citations

Receptors for the TGF-β family

1992 • 638 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome

1994 • 617 citations

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

1993 • 542 citations

The ins and outs of fibroblast growth factors

1994 • 535 citations

An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase

1993 • 520 citations

Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate.

1992 • 511 citations

Structure and function of heparan sulphate proteoglycans

1986 • 485 citations

Unique Expression Pattern of the FGF Receptor 3 Gene during Mouse Organogenesis

1993 • 456 citations

Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes

1995 • 455 citations

Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor.

1993 • 449 citations

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

1994 • 432 citations

Integral membrane heparan sulfate proteoglycans

1993 • 423 citations

Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3.

1991 • 415 citations

Members of the syndecan family of heparan sulfate proteoglycans are expressed in distinct cell-, tissue-, and development-specific patterns.

1994 • 413 citations

Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.

1993 • 408 citations

The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.

1991 • 406 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

More to “heparin” than anticoagulation

1994 • 346 citations

Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component.

1994 • 327 citations

Differential Splicing in the Extracellular Region of Fibroblast Growth Factor Receptor 1 Generates Receptor Variants with Different Ligand-Binding Specificities

1992 • 321 citations

Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1

1994 • 301 citations

A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.

1992 • 272 citations

Examination of the substrate specificity of heparin and heparan sulfate lyases

1990 • 265 citations

Functions of fibroblast growth factors and their receptors

1995 • 254 citations

Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon.

1995 • 253 citations

Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas.

1994 • 243 citations

Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.

1993 • 240 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Fibroblast growth factor receptors have different signaling and mitogenic potentials

1994 • 214 citations

Specific heparan sulfate saccharides mediate the activity of basic fibroblast growth factor.

1994 • 202 citations

Fibroblast growth factors and their receptors: An information network controlling tissue growth, morphogenesis and repair

1994 • 195 citations

Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities.

1992 • 195 citations

Ligand-induced transphosphorylation between different FGF receptors.

1991 • 189 citations

Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation

1994 • 186 citations

Fibroblast growth factors in mammalian development

1995 • 182 citations

Structure of a heparan sulphate oligosaccharide that binds to basic fibroblast growth factor

1992 • 173 citations

Novel FGFR2 mutations in Crouzon and Jackson-Weiss syndromes show allelic heterogeneity and phenotypic variability

1995 • 171 citations

A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold.

1992 • 165 citations

Fibroblast growth factor receptors have different signaling and mitogenic potentials.

1994 • 136 citations

Mutations in the third immunoglobulin domain of the fibroblast growth factor receptor-2 gene in Crouzon syndrome

1995 • 136 citations

Patterns of sulphation in heparan sulphate: Polymorphism based on a common structural theme

1992 • 133 citations

Fibroblast growth factor receptors display both common and distinct signaling pathways.

1995 • 125 citations

Control of Fibroblast Growth Factor Receptor Kinase Signal Transduction by Heterodimerization of Combinatorial Splice Variants

1993 • 124 citations

A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity.

1992 • 112 citations

Structural requirements in heparin for binding and activation of FGF-1 and FGF-4 are different from that for FGF-2

1994 • 100 citations

A novel form of FGF receptor‐3 using an alternative exon in the immunoglobulin domain III

1993 • 99 citations

Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants.

1993 • 79 citations

Preferential alternative splicing in cancer generates a K-sam messenger RNA with higher transforming activity.

1994 • 72 citations

Heparan sulfate fibroblast growth factor receptor complex: Structure-function relationships

1994 • 66 citations

Predisposition for cysteine substitutions in the immunoglobulin-like chain of FGFR2 in Crouzon syndrome

1995 • 50 citations

A Truncated K-sam Product Lacking the Distal Carboxyl-Terminal Portion Provides a Reduced Level of Autophosphorylation and Greater Resistance against Induction of Differentiation

1995 • 25 citations

Molecular cloning and expression of the acidic fibroblast growth factor receptors in a rat parathyroid cell line (PT-r). Parathyroid cell-specific calcium-dependent change of ligand accessibility and covalent attachment of heparan sulfate glycosaminoglycan to the receptors.

1994 • 18 citations

Ligand Binding by Fibroblast Growth Factor Receptors Investigated Using Chimeric Receptor Molecules

1995 • 9 citations

Fibroblast growth factor receptor (FGFR)

2014 • 7 citations

ONCOPROTEIN FOS ACTIVATION IN EPITHELIAL-CELLS INDUCES AN EPITHELIOMESENCHYMAL CONVERSION AND CHANGES THE RECEPTOR ENCODED BY THE FGFR-2 MESSENGER-RNA FROM K-SAM TO BEK

1995 • 4 citations