Membrane Translocation of 15-Lipoxygenase in Hematopoietic Cells Is Calcium-Dependent and Activates the Oxygenase Activity of the Enzyme

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

Leukotrienes and Other Products of the 5-Lipoxygenase Pathway

1990 • 1,216 citations

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1990 • 777 citations

Studies on the electron transfer system IV. The electron transfer particle

1956 • 592 citations

Cytosolic phospholipase A2

1995 • 530 citations

The Three-Dimensional Structure of an Arachidonic Acid 15-Lipoxygenase

1993 • 460 citations

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

1993 • 397 citations

Crystal Structure of Soybean Lipoxygenase L-1 at 1.4 Å Resolution^,

1996 • 395 citations

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

1992 • 382 citations

Studies on the Electron Transfer System

1962 • 335 citations

Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.

1988 • 323 citations

The Lipoxygenase of Reticulocytes

1979 • 280 citations

Oxygenation of biological membranes by the pure reticulocyte lipoxygenase.

1990 • 244 citations

Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.

1994 • 231 citations

Separation of human eosinophils in density gradients of polyvinylpyrrolidone-coated silica gel (Percoll).

1980 • 205 citations

A lipoxygenase in rabbit reticulocytes which attacks phospholipids and intact mitochondria

1975 • 202 citations

5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.

1995 • 192 citations

Redistribution of 5-Lipoxygenase and Cytosolic Phospholipase A2 to the Nuclear Fraction upon Macrophage Activation

1993 • 181 citations

Oxygenation of lipoproteins by mammalian lipoxygenases

1993 • 163 citations

Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells.

1994 • 153 citations

The molecular biology of mammalian arachidonic acid metabolism

1991 • 151 citations

Overexpression, purification and characterization of human recombinant 15-lipoxygenase

1993 • 136 citations

Translocation and Leukotriene Synthetic Capacity of Nuclear 5-Lipoxygenase in Rat Basophilic Leukemia Cells and Alveolar Macrophages

1995 • 133 citations

Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells.

1991 • 122 citations

FLAP: a novel drug target for inhibiting the synthesis of leukotrienes

1991 • 97 citations

Rabbit reticulocyte lipoxygenase catalyzes specific 12(S) and 15(S) oxygenation of arachidonoyl-phosphatidylcholine

1988 • 95 citations

Defining the Arachidonic Acid Binding Site of Human 15-Lipoxygenase

1996 • 93 citations

Phenylalanine 353 is a Primary Determinant for the Positional Specificity of Mammalian 15-Lipoxygenases

1996 • 90 citations

Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)xy-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)xy-9Z,11E-octadecadienoic acid

1996 • 89 citations

Red cell calcium content and transmembrane calcium movements in sickle cell anemia.

1977 • 89 citations

Membrane association of active 5-lipoxygenase in resting cells. Evidence for novel regulation of the enzyme in the rat alveolar macrophage.

1992 • 81 citations

5-Lipoxygenase-activating protein (FLAP)

1995 • 73 citations

Kinetic analysis of the induction period in lipoxygenase catalysis

1993 • 61 citations

Arachidonate 15-hpoxygenase

1995 • 61 citations

Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase

1985 • 60 citations

Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity

1995 • 58 citations

Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: Partial purification and properties

1988 • 56 citations

Identification of a Specific Methionine in Mammalian 15-Lipoxygenase Which Is Oxygenated by the Enzyme Product 13-HPODE: Dissociation of Sulfoxide Formation from Self-Inactivation

1995 • 52 citations

Arachidonate 12-lipoxygenase

1995 • 50 citations

Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes*

1990 • 45 citations

Maturational Breakdown of Mitochondria and Other Organelles in Reticulocytes

1990 • 40 citations

Calcium promotes membrane association of reticulocyte 15-lipoxygenase

1994 • 39 citations

Mechanisms of perturbation of erythrocyte calcium homeostasis in favism

1992 • 38 citations

Photolysis of "purple" lipoxygenase: Implications for the structure of the chromophore

1995 • 35 citations

Mutation-deletion analysis of a Ca2+-dependent phospholipid binding (CaLB) domain within p120 GAP, a GTPase-activating protein for p21 ras

1995 • 25 citations

A23187 stimulates translocation of 5-lipoxygenase from cytosol to membrane in human alveolar macrophages

1992 • 7 citations

Molecular biology of 5-lipoxygenase

2004 • 4 citations