Tyrosine phosphatase antagonist-induced activation of the neutrophil NADPH oxidase: a possible role for protein kinase C.

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Chelerythrine is a potent and specific inhibitor of protein kinase C

1990 • 1,208 citations

The biochemical basis of the NADPH oxidase of phagocytes

1993 • 631 citations

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1993 • 523 citations

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

1991 • 488 citations

SH2/SH3 signaling proteins

1994 • 457 citations

Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components.

1991 • 346 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.

1994 • 286 citations

Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils

1989 • 256 citations

Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

1990 • 248 citations

Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.

1992 • 175 citations

Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl coenzyme A

1991 • 163 citations

Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil

1992 • 160 citations

An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex.

1994 • 160 citations

Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor.

1993 • 155 citations

Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils.

1992 • 141 citations

Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase

1990 • 129 citations

Protein kinase C isotypes and signal-transduction in human neutrophils: Selective substrate specificity of calcium-dependent β-PKC and novel calcium-independent nPKC

1993 • 126 citations

Relationship between phosphorylation and translocation to the plasma membrane of p47phox and p67phox and activation of the NADPH oxidase in normal and Ca2+-depleted human neutrophils

1993 • 125 citations

Protein kinase C-dependent and -independent activation of the NADPH oxidase of human neutrophils.

1991 • 120 citations

Localization of the 47 kDa phosphoprotein involved in the respiratory-burst NADPH oxidase of phagocytic cells

1989 • 117 citations

Involvement of tyrosine kinases in the activation of human peripheral blood neutrophils by granulocyte-macrophage colony-stimulating factor

1991 • 105 citations

Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox

1993 • 101 citations

Vanadate stimulates oxygen consumption and tyrosine phosphorylation in electropermeabilized human neutrophils.

1990 • 99 citations

Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells

1989 • 99 citations

The immediate activator of the NADPH oxidase is arachidonate not phosphorylation

1993 • 82 citations

Recombinant human monocyte IL-8 primes NADPH-oxidase and phospholipase A2 activation in human neutrophils.

1992 • 80 citations

Tissue-specific expression and developmental regulation of the human fgr proto-oncogene.

1989 • 75 citations

Granulocyte-macrophage colony-stimulating factor activates microtubule- associated protein 2 kinase in neutrophils via a tyrosine kinase- dependent pathway

1992 • 57 citations

Stimulation of neutrophils with a chemoattractant activates several novel protein kinases that can catalyze the phosphorylation of peptides derived from the 47-kDa protein component of the phagocyte oxidase and myristoylated alanine-rich C kinase substrate

1993 • 55 citations

The phosphotyrosine phosphatase inhibitor vanadyl hydroperoxide induces morphological alterations, cytoskeletal rearrangements and increased adhesiveness in rat neutrophil leucocytes

1993 • 45 citations

Activation of permeabilized HL60 cells by vanadate. Evidence for divergent signalling pathways

1990 • 37 citations

Priming of the oxidative burst in human neutrophils by physiological agonists or cytochalasin B results from the recruitment of previously non-responsive cells.

1994 • 29 citations

Tissue-Specific Expression and Developmental Regulation of the Human fgr Proto-Oncogene

1989 • 14 citations