Transfection of the human malaria parasite Plasmodium falciparum

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

1988 • 634 citations

Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil

1997 • 509 citations

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

1988 • 507 citations

Chromosome 2 Sequence of the Human Malaria Parasite Plasmodium falciparum

1998 • 455 citations

Targeted Gene Disruption Shows That Knobs Enable Malaria-Infected Red Cells to Cytoadhere under Physiological Shear Stress

1997 • 437 citations

Insertional Tagging, Cloning, and Expression of the Hypoxanthine-Xanthine-Guanine Phosphoribosyltransferase Gene

1996 • 424 citations

Transfection of Plasmodium falciparum within human red blood cells.

1995 • 383 citations

Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine.

1996 • 380 citations

Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria.

1993 • 352 citations

Characterization of promoters and stable transfection by homologous and nonhomologous recombination in Plasmodium falciparum.

1996 • 272 citations

Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria

1998 • 271 citations

Stable Transfection of Malaria Parasite Blood Stages

1995 • 239 citations

The methotrexate story: A paradigm for development of cancer chemotherapeutic agents

1994 • 234 citations

Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum.

1986 • 220 citations

Insertional mutagenesis and marker rescue in a protozoan parasite: cloning of the uracil phosphoribosyltransferase locus from Toxoplasma gondii.

1995 • 189 citations

Transfection of Plasmodiium falciparum within human red biood cells

1995 • 163 citations

Trans-kingdom Transposition of the Drosophila Element mariner Within the Protozoan Leishmania

1997 • 146 citations

Stable transgene expression in Plasmodium falciparum

1997 • 142 citations

Transfection of the malaria parasite and expression of firefly luciferase.

1993 • 115 citations

Homologous recombination and gene replacement at the dihydrofolate reductase-thymidylate synthase locus in Toxoplasma gondii

1994 • 94 citations

Transfection of the Primate Malaria Parasite Plasmodium knowlesi Using Entirely Heterologous Constructs

1997 • 85 citations

Tetracycline-controlled gene expression in Entamoeba histolytica

1997 • 81 citations

A tetracycline-inducible gene expression system in Entamoeba histolytica

1997 • 76 citations

Pyrimethamine resistant mutations in Plasmodium falciparum

1992 • 70 citations

Mutational analysis identifies a five base pair cis-acting sequence essential for GBP130 promoter activity in Plasmodium falciparum

1999 • 63 citations

Physical and functional mapping of the transcriptional start sites of Plasmodium falciparum proliferating cell nuclear antigen

1996 • 55 citations

Expression of green fluorescent protein in Plasmodium falciparum

1997 • 47 citations

Replication, expression and segregation of plasmid-borne DNA in genetically transformed malaria parasites

1997 • 47 citations

Analogues of N-benzyloxydihydrotriazines:in vitroantimalarial activity againstPlasmodium falciparum

1986 • 47 citations

Development of a Stable Episomal Shuttle Vector for Toxoplasma gondii

1998 • 42 citations

An unexpected 5′ untranslated intron in the P. falciparum genes for histidine-rich proteins II and III

1996 • 16 citations

State-Specific Expressions of the Calmodulin Gene in Plasmodium falciparum1

1995 • 13 citations

Stable transfection of the blood stages of malarial parasites

1997 • 2 citations