Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine.

Pyrimethamine and Proguanil Resistance-Conferring Mutations in Plasmodium falciparum Dihydrofolate Reductase: Polymerase Chain Reaction Methods for Surveillance in Africa

1995 • 665 citations

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

1988 • 634 citations

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

1988 • 507 citations

Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.

1990 • 417 citations

Transfection of Plasmodium falciparum within human red blood cells.

1995 • 383 citations

Transient Transfection and Expression in the Obligate Intracellular Parasite Toxoplasma gondii

1993 • 353 citations

Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria.

1993 • 352 citations

Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.

1990 • 304 citations

Gene Replacement in Toxoplasma gondii with Chloramphenicol Acetyltransferase as Selectable Marker

1993 • 283 citations

Stable Transfection of Malaria Parasite Blood Stages

1995 • 239 citations

Gene replacement in parasitic protozoa

1990 • 238 citations

Cloning of Naturally Occurring Mixed Infections of Malaria Parasites

1981 • 221 citations

Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum.

1986 • 220 citations

A histidine-rich protein gene marks a linkage group favored strongly in a genetic cross of Plasmodium falciparum

1987 • 211 citations

Insertional mutagenesis and marker rescue in a protozoan parasite: cloning of the uracil phosphoribosyltransferase locus from Toxoplasma gondii.

1995 • 189 citations

Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei

1990 • 177 citations

Homologous Recombination and Stable Transfection in the Parasitic Protozoan Trypanosoma brucei

1990 • 135 citations

Stable DNA transformation in the obligate intracellular parasite Toxoplasma gondii by complementation of tryptophan auxotrophy.

1994 • 128 citations

Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum

1989 • 115 citations

Transfection of the malaria parasite and expression of firefly luciferase.

1993 • 115 citations

Homologous recombination and gene replacement at the dihydrofolate reductase-thymidylate synthase locus in Toxoplasma gondii

1994 • 94 citations

Stable integrative transformation of Trypanosoma brucei that occurs exclusively by homologous recombination.

1991 • 94 citations

Plasmid migration using orthogonal-field-alternation gel electrophoresis

1987 • 71 citations

Pyrimethamine resistant mutations in Plasmodium falciparum

1992 • 70 citations

Stable transformation of Trypanosoma brucei

1993 • 46 citations

Restriction polymorphisms and fingerprint patterns from an interspersed repetitive element of Plasmodium falciparum DNA

1993 • 34 citations

Migration of a novel DQA1∗ allele (DQA1∗0502) from African origin to North and South America

1995 • 19 citations

A sequence insertion targeting vector for Leishmania enriettii.

1992 • 14 citations

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