Homologous recombination and gene replacement at the dihydrofolate reductase-thymidylate synthase locus in Toxoplasma gondii

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Yeast transformation: a model system for the study of recombination.

1981 • 1,491 citations

Toxoplasmic Encephalitis in AIDS

1992 • 1,293 citations

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

1988 • 634 citations

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

1988 • 507 citations

Electroporation in ‘intracellular’ buffer increases cell survival

1992 • 460 citations

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Gene replacement in parasitic protozoa

1990 • 238 citations

The length of homology required for gene targeting in embryonic stem cells.

1991 • 234 citations

Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells.

1991 • 187 citations

Homologous Recombination and Stable Transfection in the Parasitic Protozoan Trypanosoma brucei

1990 • 135 citations

The dihydrofolate reductase-thymidylate synthetase gene in the drug resistance of malaria parasites

1990 • 135 citations

Generation of a restriction fragment length polymorphism linkage map for Toxoplasma gondii.

1992 • 134 citations

Efficient site-directed in vitro mutagenesis using phagemid vectors.

1989 • 118 citations

A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae.

1991 • 106 citations

Determination of nuclear DNA of five Eucoccidian parasites, Isospora (Toxoplasma) gondii, Sarcocystis cruzi, Eimeria tenella, E. acervulina and Plasmodium berghei, with special reference to gamontogenesis and meiosis in I. (T.) gondii

1984 • 103 citations

Primary structure of the dihydrofolate reductase-thymidylate synthase gene from Toxoplasma gondii.

1993 • 95 citations

Toxoplasma gondii: Genetic recombination between drug resistant mutants

1980 • 91 citations

Homologous Recombination in Hybridoma Cells: Dependence on Time and Fragment Length

1990 • 80 citations

Modern Parasite Biology

1991 • 76 citations

Pyrimethamine resistant mutations in Plasmodium falciparum

1992 • 70 citations

Stable transformation of Trypanosoma brucei

1993 • 46 citations

Dihydrofolate reductase mutations and chromosomal changes associated with pyrimethamine resistance of Plasmodium falciparum

1990 • 45 citations

A sequence insertion targeting vector for Leishmania enriettii.

1992 • 14 citations

Overview of Gene Targeting by Homologous Recombination

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