β‐Lactamase inhibitors

The structure of β-lactamases

1980 • 1,705 citations

The β-Lactamases of Gram-Negative Bacteria and their Possible Physiological Role

1973 • 719 citations

Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus

1977 • 695 citations

The β-lactamases of Gram-negative bacteria and their rôle in resistance to β-lactam antibiotics

1976 • 539 citations

Thienamycin, a new .BETA.-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.

1979 • 502 citations

Enzyme-Activated Irreversible Inhibitors

1979 • 420 citations

CP-45,899, a Beta-Lactamase Inhibitor That Extends the Antibacterial Spectrum of Beta-Lactams: Initial Bacteriological Characterization

1978 • 399 citations

ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.

1981 • 384 citations

Sulfazecin and isosulfazecin, novel β-lactam antibiotics of bacterial origin

1981 • 333 citations

Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria

1982 • 326 citations

Clavulanic Acid, a Novel Inhibitor of β-Lactamases

1978 • 236 citations

Plasmid-mediated β-lactamases of Gram-negative bacteria: properties and distribution

1979 • 227 citations

Kinetic studies on the inactivation of Escherichia coli RTEM β-lactamase by clavulanic acid

1978 • 204 citations

Cephalosporinase and penicillinase activities of a β-lactamase from Pseudomonas pyocyanea

1965 • 195 citations

Kinetics of suicide substrates

1980 • 188 citations

N-Acetimidoyl- and N-formimidoylthienamycin derivatives: antipseudomonal .beta.-lactam antibiotics

1979 • 161 citations

The inhibition of class C β-lactamases by boronic acids

1983 • 154 citations

Zinc as a Cofactor for Cephalosporinase from Bacillus cereus 569

1966 • 144 citations

In vitro synergistic properties of clavulanic acid, with ampicillin, amoxycillin and ticarcillin

1980 • 138 citations

Enzyme‐Activated Irreversible Inhibitors

1980 • 134 citations

Reversible inhibitors of penicillinases

1978 • 131 citations

Penicillinase active sites: Labelling of serine‐44 in β‐lactamase I by 6β‐bromopenicillanic acid

1979 • 129 citations

Inactivation of the RTEM .beta.-lactamase from Escherichia coli. Interaction of penam sulfones with the enzyme

1981 • 110 citations

Cefoxitin, a Semisynthetic Cephamycin Antibiotic: Susceptibility Studies

1974 • 108 citations

Penicillanic acid sulfone: an unexpected isotope effect in the interaction of 6.alpha.- and 6.beta.-monodeuterio and of 6,6-dideuterio derivatives with RTEM .beta.-lactamase from Escherichia coli. Crystal structure of penicillanic acid sulfone

1981 • 107 citations

Resistance of Escherichia coli to Penicillins VI. Purification and Characterization of the Chromosomally Mediated Penicillinase Present in ampA -Containing Strains

1970 • 106 citations

Inactivation of Bacillus cereus .beta.-lactamase I by 6.beta.-bromopenicillanic acid: kinetics

1980 • 105 citations

6-beta-bromopenicillanic acid, a potent beta-lactamase inhibitor.

1978 • 105 citations

Topics in antibiotic chemistry

1980 • 103 citations

Cefuroxime - A new cephalosporin antibiotic.

1976 • 98 citations

The acyl-enzyme mechanism of β-lactamase action. The evidence for class C β-lactamases

1982 • 96 citations

Cefoxitin, a Semisynthetic Cephamycin Antibiotic: Antibacterial Spectrum and Resistance to Hydrolysis by Gram-Negative Beta-Lactamases

1974 • 91 citations

A semi-synthetic penicillinase inactivator

1979 • 91 citations

Acquisition of substrate-specific parameters during the catalytic reaction of penicillinase.

1976 • 85 citations

Olivanic acids, a family of .BETA.-lactam antibiotics with .BETA.-lactamase inhibitory properties produced by Streptomyces species. I. Detection, properties and fermentation studies.

1979 • 82 citations

Chemical studies on the inactivation of Escherichia coli RTEM β-lactamase by clavulanic acid

1978 • 80 citations

The inhibition of staphylococcal β-lactamase by clavulanic acid

1979 • 80 citations

β-Lactamase inactivation by mechanism-based reagents

1980 • 79 citations

Behaviour of some derivatives of 7-aminocephalosporanic acid and 6-aminopenicillanic acid as substrates, inhibitors and inducers of penicillinases

1962 • 78 citations

Kinetics of suicide substrates steady-state treatments and computer-aided exact solutions

1981 • 75 citations

6 β-Bromopenicillanic acid inactivates β-lactamase I

1979 • 75 citations

Synergistic Action of Penicillins and Cephalosporins Against Pseudomonas pyocyanea

1964 • 73 citations

Comparative Inhibition of β-Lactamases by Novel β-Lactam Compounds

1979 • 73 citations

Active sites of β-lactamases. The chromosomal β-lactamases of Pseudomonas aeruginosa and Escherichia coli

1982 • 72 citations

Antibiotic resistance in pathogenic and producing bacteria, with special reference to beta-lactam antibiotics

1981 • 72 citations

Inhibition of the RTEM .beta.-lactamase from Escherichia coli. Interaction of the enzyme with derivatives of olivanic acid

1981 • 70 citations

Inhibition of the RTEM .beta.-lactamase from Escherichia coli. Interaction of the enzyme with derivatives of olivanic acid

1982 • 70 citations

Total synthesis of thienamycin analogs. 1. Synthesis of the thienamycin nucleus and dl-decysteaminylthienamycin

1978 • 67 citations

Penems and related substances

1980 • 63 citations

Cephamycins, a New Family of β-Lactam Antibiotics: Antibacterial Activity and Resistance to β-Lactamase Degradation

1973 • 60 citations

Four further antibiotics related to olivanic acid produced by Streptomyces olivaceus: Fermentation, isolation, characterisation and biosynthetic studies.

1979 • 57 citations

PS-5, A new .BETA.-lactam antibiotic from Streptomyces.

1978 • 56 citations

Isolation and structure of a .BETA.-lactamase inhibitor from Streptomyces.

1977 • 56 citations

Inactivation of Bacillus cereus .beta.-lactamase I by 6.beta.-bromopenicillanic acid: mechanism

1980 • 55 citations

Penicillanic acid sulfone: interaction with RTEM .beta.-lactamase from Escherichia coli at different pH values

1981 • 53 citations

The inhibition of β-lactamases from Gram-negative bacteria by clavulanic acid

1981 • 52 citations

The pH-dependence and group modification of β-lactamase I

1975 • 51 citations

Common evolutionary origin of chromosomal beta-lactamase genes in enterobacteria

1982 • 50 citations

The comparative .BETA.-lactamase resistance and inhibitory activity of 1-oxa cephalosporin, cefoxitin and cefotaxime.

1979 • 49 citations

Sulfenyl transfer rearrangement of sulfenimines (thiooximes). A novel synthesis of 7.alpha.-methoxycephalosporins and 6.alpha.-methoxypenicillins

1980 • 48 citations

Asparenomycin A, a new carbapenem antibiotic.

1981 • 48 citations

Inhibition kinetics of three R-factor-mediated β-lactamases by a new β-lactam sulfone (CP 45899)

1980 • 46 citations

The Classification and Terminology of Enzymes That Hydrolyze -Lactam Antibiotics

1982 • 45 citations

Asparenomycins A, B and C, new carbapenem antibiotics. III. Structures.

1982 • 42 citations

Mechanism of Substrate-induced Inactivation of beta-Lactamase I

1980 • 40 citations

On the determination of availability of ligand binding sites in steady-state systems

1977 • 40 citations

6-β-Bromo- and 6-β-iodo penicillanic acid, two novel β-lactamase inhibitors

1981 • 39 citations

Purification and properties of a constitutive β-lactamase from Pseudomonas aeruginosa strain dalgleish

1975 • 39 citations

Effect of N-formimidoyl thienamycin (MK0787) on beta-lactamases and activity against beta-lactamase-producing strains

1980 • 38 citations

The structures of pluracidomycins, new carbapenem antibiotics.

1982 • 37 citations

Comparison of the Substrate Specificities of the β-Lactamases from Klebsiella aerogenes 1082E and Enterobacter cloacae P99

1972 • 37 citations

Kinetics of inactivation of β-lactamase I by 6 β-bromopenicillanic acid

1980 • 35 citations

Asparenomycins A, B and C, new carbapenem antibiotics. V. Inhibition of .BETA.-lactamases.

1982 • 33 citations

Antibacterial activity of ceftizoxime (FK 749), a new cephalosporin, against cephalosporin-resistant bacteria, and its stability to beta-lactamase

1979 • 33 citations

New naturally occurring β-Mactam antibiotics and related compounds

1981 • 33 citations

EM5400, a family of monobactam antibiotics produced by Agrobacterium radiobacter. I. Taxonomy, fermentation and biological properties.

1982 • 33 citations

Resistance to -lactam antibiotics in Bacteroides species

1981 • 31 citations

The antimicrobial susceptibility of anaerobic bacteria in a London teaching hospital

1981 • 31 citations

Sulphydryl Groups Essential for the Penicillinase Activity of Aerobacter cloacae

1963 • 30 citations

In vitro antimicrobial activity of cefotaxime, a new cephalosporin

1980 • 28 citations

Structural requirements for antibacterial activity and β-lactamase stability of 7β-arylmalonylamino-7α-methoxy-1-oxacephems

1980 • 28 citations

Substrate-induced deactivation of penicillinases. Studies of β-lactamase I by hydrogen exchange

1977 • 28 citations

Mutant of Pseudomonas aeruginosa 18S That Synthesizes Type Id β-Lactamase Constitutively

1976 • 28 citations

‘β-Lactams’ as β-lactamase inhibitors

1980 • 28 citations

Isolation and Properties of an Inducible and a Constitutive ss- Lactamase from Pseudomonas aeruginosa

1982 • 27 citations

Chapter 25. Bacterial Resistance to β-Lactams: The β-Lactamases

1978 • 26 citations

beta-lactamase from Streptomyces cacaoi. Purification and properties.

1981 • 26 citations

C-19393 S2 and H2, new carbapenem antibiotics. IV. Inhibitory activity against .BETA.-lactamases.

1981 • 25 citations

The exocellular β-lactamase of Streptomyces albus G. Purification, properties and comparison with the exocellular <scp>dd</scp>-carboxypeptidase

1981 • 24 citations

Epimerization of 6.alpha.-bromopenicillanic acid and preparation of 6.beta.-bromopenicillanic acid

1978 • 24 citations

Izumenolide - a novel .BETA.-lactamase inhibitor produced by Micromonospora. II. Biological properties.

1980 • 23 citations

PS-5 inhibition of a .BETA.-lactamase from Proteus vulgaris.

1980 • 23 citations

Inhibition of β-lactamase of Bacillus licheniformis 749/C by compound PS-5, a new β-lactam antibiotic

1980 • 22 citations

A novel .BETA.-lactamase inhibitor, SF-2103 a produced by a Streptomyces.

1982 • 21 citations

A stereocontrolled, enantiomerically specific total synthesis of thienamycin

1980 • 21 citations

Active sites of β-lactamases from Bacillus cereus

1980 • 21 citations

Antimicrobial and beta-lactamase inhibitory activities of carpetimycins A and B, new carbapenem antibiotics

1982 • 20 citations

Interaction between serine β-lactamases and class a substrates: A kinetic analysis and a reaction pathway hypothesis

1981 • 18 citations

Dotriacolide, a new .BETA.-lactamase inhibitor.

1981 • 17 citations

Certain monocyclic β-lactams are β-lactamase substrates: Nocardicin A and desthiobenzylpenicillin

1980 • 16 citations

Phenylpropynal, a specific, irreversible, non-beta-lactam inhibitor of beta-lactamases.

1980 • 16 citations

Kinetics of β-Lactamase Inactivation of Penicillins I: Effect of Side-Chain Structure, Ionic Strength, pH, and Temperature

1973 • 15 citations

Total synthesis of β-lactamase inhibitors related to clavulanic acid

1977 • 15 citations

Studies related to dihydro-1,4-thiazines. Part VI. Thermal racemisation of sulphoxides

1974 • 13 citations

Structure-activity relations and β-lactamase resistance

1980 • 11 citations

4 Functional Modifications and Nuclear Analogues of β -Lactam Antibiotics -Part II

1977 • 11 citations

In Vitro and In Vivo Activity of Penicillinase Inhibitor KA-107 Against Staphylococcus aureus FS-1277

1973 • 8 citations

The inhibition of bacterial .BETA.-lactamases by some monocyclic .BETA.-lactams.

1982 • 7 citations

THE PROGRESS OF CHEMOTHERAPY

2011 • 6 citations