Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock
Data up to Jan 2025
Total Citations Per Year
Abstract
References (103)
Bias in meta-analysis detected by a simple, graphical test
1997 • 47,526 citations
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
1992 • 12,726 citations
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
2001 • 9,683 citations
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
2003 • 5,388 citations
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
2007 • 4,077 citations
Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin
1991 • 1,611 citations
Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein
1996 • 1,217 citations
Treatment of Gram-Negative Bacteremia and Shock with Human Antiserum to a MutantEscherichia coli
1982 • 1,062 citations
Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group
1994 • 920 citations
Confirmatory interleukin-1 receptor antagonist trial in severe sepsis
1997 • 822 citations
Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome
1995 • 805 citations
A Controlled Clinical Trial of E5 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis
1991 • 741 citations
Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome
1994 • 714 citations
Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.
1989 • 709 citations
Anti-inflammatory therapies to treat sepsis and septic shock
1997 • 656 citations
Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group.
1998 • 618 citations
Inflammation: Basic Principles and Clinical Correlates
2000 • 616 citations
Intravenous Immunoglobulin Therapy for Streptococcal Toxic Shock Syndrome—A Comparative Observational Study
1999 • 537 citations
Intravenous Immunoglobulin G Therapy in Streptococcal Toxic Shock Syndrome: A European Randomized, Double-Blind, Placebo-Controlled Trial
2003 • 534 citations
INTERSEPT
1996 • 492 citations
Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebocontrolled multicenter trial
1994 • 488 citations
Treatment of Septic Shock with Human Monoclonal Antibody HA-1A
1994 • 474 citations
Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock
1998 • 458 citations
Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis
1993 • 427 citations
Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock
1996 • 368 citations
Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab′)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels*
2004 • 365 citations
A second large controlled clinical study of E5, a monoclonal antibody to endotoxin
1995 • 348 citations
Large Trials vs Meta-analysis of Smaller Trials
1996 • 337 citations
Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock
2002 • 316 citations
Treatment of Gram-Negative Septic Shock with Human IgG Antibody to Escherichia coli J5: A Prospective, Double-Blind, Randomized Trial
1988 • 266 citations
Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock*
2007 • 260 citations
E5 Murine Monoclonal Antiendotoxin Antibody in Gram-Negative Sepsis<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
2000 • 256 citations
Anti-Endotoxin Monoclonal Antibodies
1992 • 235 citations
Predictive ability of meta-analyses of randomised controlled trials
1995 • 232 citations
Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: A systematic review and meta-analysis*
2007 • 220 citations
Score-based immunoglobulin G therapy of patients with sepsis: The SBITS study*
2007 • 208 citations
Meta-analysis: Intravenous Immunoglobulin in Critically Ill Adult Patients with Sepsis
2007 • 180 citations
Intravenous immunoglobulin for suspected or subsequently proven infection in neonates
2004 • 165 citations
Long-term survival after intensive care unit admission with sepsis
1995 • 159 citations
Randomized, Placebo‐Controlled Trial of HA‐1A, a Human Monoclonal Antibody to Endotoxin, in Children with Meningococcal Septic Shock
1999 • 159 citations
CDP571, a humanized antibody to human tumor necrosis factor-alpha
1995 • 152 citations
Adverse Effects of Intravenous Immunoglobulin Therapy
1999 • 140 citations
Polyclonal Immunoglobulin for Treatment of Bacterial Sepsis: A Systematic Review
2004 • 139 citations
Protein C and S deficiency in severe infectious purpura of children: A collaborative study of 40 cases
1992 • 136 citations
IgM-Enriched Intravenous Immunoglobulin Therapy in Neonatal Sepsis
1988 • 133 citations
ANTI-LIPOPOLYSACCHARIDE IMMUNOTHERAPY IN MANAGEMENT OF SEPTIC SHOCK OF OBSTETRIC AND GYNAECOLOGICAL ORIGIN
1984 • 126 citations
A Critical Evaluation of New Agents for the Treatment of Sepsis
1991 • 109 citations
Effectiveness of a Human Monoclonal Anti-Endotoxin Antibody (HA-1A) in Gram-Negative Sepsis: Relationship to Endotoxin and Cytokine Levels
1992 • 109 citations
Effects of High-Dose IgG on Survival of Surgical Patients With Sepsis Scores of 20 or Greater
1991 • 104 citations
Strategies for blocking the systemic effects of cytokines in the sepsis syndrome
1995 • 98 citations
Round table conference on clinical trials for the treatment of sepsis
1995 • 98 citations
Effect on neutrophil kinetics and serum opsonic capacity of intravenous administration of immune globulin to neonates with clinical signs of early-onset sepsis
1991 • 98 citations
Intravenous immune globulin therapy for early-onset sepsis in premature neonates
1992 • 93 citations
Intravenous Immunoglobulin Adjunctive Therapy in Sepsis, with Special Emphasis on Severe Invasive Group A Streptococcal Infections
2003 • 93 citations
Meta-analyses of the Effectiveness of Intravenous Immune Globulin for Prevention and Treatment of Neonatal Sepsis
1997 • 87 citations
Intravenous Polyclonal Immunoglobulin Administration to Sepsis Syndrome Patients: A Prospective Study in a Pediatric Intensive Care Unit
2005 • 86 citations
IgMA-enriched immunoglobulin in neutropenic patients with sepsis syndrome and septic shock: A randomized, controlled, multiple-center trial*
2006 • 81 citations
Meningococcal Septic Shock in Children: Clinical and Laboratory Features, Outcome, and Development of a Prognostic Score
1997 • 78 citations
Immunoglobulin supplementation in prevention or treatment of neonatal sepsis
1986 • 77 citations
Epidemiology and outcome of sepsis in a tertiary-care hospital in a developing country
2005 • 76 citations
Plasma Tumor Necrosis Factor Levels in Patients With Presumed Sepsis
1989 • 74 citations
Randomized trial of granulocyte transfusions versus intravenous immune globulin therapy for neonatal neutropenia and sepsis
1992 • 73 citations
Administration of intravenous immunoglobulins for prophylaxis or treatment of infection in preterm infants: meta-analyses.
1995 • 70 citations
Comparison of two types of intravenous immunoglobulins in the treatment of neonatal sepsis
1995 • 69 citations
The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis [ISRCTN28863830].
2002 • 69 citations
Intravenous immunoglobulins in association with antibiotics
1988 • 68 citations
Multicenter evaluation of a human monoclonal antibody to Entero-bacteriaceae common antigen in patients with Gram-negative sepsis
2003 • 59 citations
Comparison of Early IgM-Enriched Immunoglobulin vs Polyvalent IgG Administration in Score-Identified Postcardiac Surgical Patients at High Risk for Sepsis
1997 • 52 citations
Pathophysiology of Septic Shock and Multiple Organ Dysfunction Syndrome and Various Therapeutic Approaches with Special Emphasis on Immunoglobulins
2001 • 44 citations
Sepsis And Multiorgan Failure
1997 • 44 citations
Supplemental immune globulins in sepsis: a critical appraisal
1996 • 43 citations
High-Dose Intravenous IgG for Treatment of Severe Surgical Infections
1996 • 42 citations
Improving clinical trials in the critically ill: Unique challenge—Sepsis
2008 • 42 citations
Multicenter randomized placebo controlled trial of therapy with intravenous immunoglobulin in decreasing mortality due to neonatal sepsis.
1999 • 41 citations
Treatment of septic thrombocytopenia with immune globulin
1991 • 40 citations
Observations using antiendotoxin antibody (E5) as adjuvant therapy in humans with suspected, serious, Gram-negative sepsis
1992 • 40 citations
Cooperative group of additional immunoglobulin therapy in severe bacterial infections: Results of a multicenter randomized controlled trial in cases of diffuse fibrinopurulent peritonitis
1987 • 40 citations
The use of IgM-enriched intravenous immunoglobulin for the treatment of neonatal sepsis in preterm infants.
1993 • 36 citations
Impact of Immunomodulating Therapy on Morbidity in Patients with Severe Sepsis
1999 • 36 citations
Immunoglobulin therapy in patients with endotoxemia and postoperative sepsis--a prospective randomized study.
1988 • 31 citations
Intravenous immunoglobulin in the treatment of full-term and premature newborns with sepsis.
1996 • 30 citations
[Immunoglobulin therapy of postoperative sepsis].
1990 • 26 citations
Intravenous Immunoglobulin in the Treatment of Salmonella Typhimurium Infections in Preterm Neonates
1994 • 25 citations
Pepsin‐Treated Human Gamma Globulin in Bacterial Infections: A Randomized Study in Patients with Septicaemia and Pneumonia
1981 • 21 citations
[Intravenous immunoglobulin in the treatment of neonatal septicemia].
1992 • 20 citations
Functional Antibacterial Activity of a Human Intravenous Immunoglobulin Preparation: in vitro and in vivo Studies
1983 • 19 citations
POLYVALENT IMMUNE GLOBULINS
1997 • 17 citations
Exchange transfusion or intravenous immunoglobulin therapy as an adjunct to antibiotics for neonatal sepsis in developing countries: a pilot study
2006 • 16 citations
An evaluation of the hemodynamic effects of HA-1A human monoclonal antibody
1994 • 13 citations
Treatment of Gram-Negative Septic Shock With an Immunoglobulin Preparation
1993 • 12 citations
The microbiology and outcome of sepsis in Victoria, Australia
2005 • 12 citations
Prophylactic anti-lipopolysaccharide freeze-dried plasma in major burns: a double blind controlled trial
1995 • 11 citations
Sepsis and polyspecific intravenous immunoglobulins
1997 • 11 citations
Antikörper gegen Lipoid A in der Behandlung des septischen Schocks
1987 • 10 citations
High doses of immunoglobulins decrease mortality rate of surgical patients with severe intraabdominal infections and sepsis.
1998 • 7 citations
Safety of Intravenous Immunoglobulin Infusion in Neonates at Risk for Sepsis
1990 • 6 citations
Sepsis and Multiorgan Failure
1998 • 5 citations
The significance of immunoglobulins in the treatment of patients with sepsis and septic shock.
1998 • 4 citations
Treatment of septic thrombocytopenia with immunoglobulin
2006 • 3 citations
[Clinical studies on the effectiveness of SM-4300, a new non-modified gammaglobulin preparation suitable for intravenous use, in refractory infections].
1985 • 2 citations
The Systemic Inflammatory Response Syndrome-Reply
1995 • 2 citations
[A clinical trial of SM-4300 against severe infections in surgery].
1985 • 2 citations
Author's Reply1
1986 • 1 citations