Impact of Immunomodulating Therapy on Morbidity in Patients with Severe Sepsis

An Introduction to the Bootstrap

1994 • 39,661 citations

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee

1995 • 2,104 citations

The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

1995 • 2,007 citations

The Prevalence of Nosocomial Infection in Intensive Care Units in Europe

1995 • 1,469 citations

Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality

1994 • 1,394 citations

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

1996 • 1,217 citations

Septic Shock in Humans

1990 • 1,170 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

Analysis and Interpretation of Treatment Effects in Subgroups of Patients in Randomized Clinical Trials

1991 • 954 citations

Nosocomial Bloodstream Infection in Critically III Patients

1994 • 895 citations

TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria

1990 • 861 citations

Tumor Necrosis Factor and Disease Severity in Children with Falciparum Malaria

1989 • 852 citations

Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome

1995 • 805 citations

The Effects of Ibuprofen on the Physiology and Survival of Patients with Sepsis

1997 • 797 citations

Activation of Coagulation after Administration of Tumor Necrosis Factor to Normal Subjects

1990 • 681 citations

Tumor necrosis factor.

1992 • 601 citations

INTERSEPT

1996 • 492 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

p55 Tumor Necrosis Factor Receptor Fusion Protein in the Treatment of Patients With Severe Sepsis and Septic Shock

1997 • 376 citations

Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock

1996 • 368 citations

The Risk Factors, Incidence, and Prognosis of ARDS following Septicemia

1983 • 254 citations

Nosocomial Bacteremia in Critically Ill Patients: A Multicenter Study Evaluating Epidemiology and Prognosis

1997 • 239 citations

Inference for Events with Dependent Risks in Multiple Endpoint Studies

1991 • 219 citations

Bedside prediction of mortality from bacteremic sepsis. A dynamic analysis of ICU patients.

1996 • 217 citations

A Simple Multiple System Organ Failure Scoring System Predicts Mortality of Patients Who Have Sepsis Syndrome

1993 • 203 citations

The Clinical Evaluation of New Drugs for Sepsis

1993 • 202 citations

The intensive care unit.

1987 • 150 citations

LETHAL STAPHYLOCOCCUS AUREUS-INDUCED SHOCK IN PRIMATES

1992 • 141 citations

Efficacy of a Monoclonal Antibody Directed against Tumor Necrosis Factor in Protecting Neutropenic Rats from Lethal Infection with Pseudomonas aeruginosa

1990 • 123 citations

Should morbidity replace mortality as an endpoint for clinical trials in intensive care?

1995 • 117 citations

Cost-effectiveness of Monoclonal Antibodies to Gram-negative Endotoxin in the Treatment of Gram-negative Sepsis in ICU Patients

1993 • 100 citations

Cost-effectiveness of HA-1A Monoclonal Antibody for Gram-Negative Sepsis

1991 • 96 citations

Monoclonal Antibody to Tumor Necrosis Factor α Attenuates Cardiopulmonary Dysfunction in Porcine Gram-negative Sepsis

1992 • 70 citations

Protection Against Rat Endotoxic Shock By p55 Tumor Necrosis Factor (TNF) Receptor Immunoadhesin: Comparison with Anti-TNF Monoclonal Antibody

1994 • 39 citations

Gram-negative sepsis, the sepsis syndrome, and the role of antiendotoxin monoclonal antibodies.

1992 • 20 citations